Brain Imaging Core

脑成像核心

基本信息

批准号：
10239779
负责人：
ANDREW L ALEXANDER
金额：
$ 19.01万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10239779
关键词：
Animal Model Anxiety Behavioral Blood flow Brain Brain imaging Cerebrum Communities Computer Systems Computer software Consultations Data Data Analytics Data Storage and Retrieval Development Diagnosis Diffusion Magnetic Resonance Imaging Educational workshop Energy Metabolism Ensure Environment Exhibits Experimental Designs Functional Magnetic Resonance Imaging Goals High Performance Computing Human Image Image Analysis Individual Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Investigation MRI Scans Magnetic Resonance Imaging Maintenance Measurement Measures Methodology Methods Modality Molecular Morphologic artifacts Motion Near-Infrared Spectroscopy Nerve Degeneration Neurosciences Neurotransmitters Participant Performance Perfusion Physics Physiologic pulse Physiological Physiology Population Positron-Emission Tomography Procedures Protocols documentation Quality Control Radiopharmaceuticals Research Research Personnel Research Project Grants Resolution Resources Rest Risk Rodent Scanning Scientist Sensory Receptors Services Software Tools Spectrum Analysis Statistical Data Interpretation Structure Students System Systems Development Talents Technical Expertise Technology Training Update animal imaging base behavioral phenotyping computer science data acquisition design human model image processing imaging modality imaging scientist insight instrument meetings neural correlate neural patterning neurochemistry neurodevelopment neuroimaging neuropathology nonhuman primate novel novel marker protocol development radiotracer relating to nervous system statistics tool white matter

Animal Model Anxiety Behavioral Blood flow Brain Brain imaging Cerebrum Communities Computer Systems Computer software Consultations Data Data Analytics Data Storage and Retrieval Development Diagnosis Diffusion Magnetic Resonance Imaging Educational workshop Energy Metabolism Ensure Environment Exhibits Experimental Designs Functional Magnetic Resonance Imaging Goals High Performance Computing Human Image Image Analysis Individual Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Investigation MRI Scans Magnetic Resonance Imaging Maintenance Measurement Measures Methodology Methods Modality Molecular Morphologic artifacts Motion Near-Infrared Spectroscopy Nerve Degeneration Neurosciences Neurotransmitters Participant Performance Perfusion Physics Physiologic pulse Physiological Physiology Population Positron-Emission Tomography Procedures Protocols documentation Quality Control Radiopharmaceuticals Research Research Personnel Research Project Grants Resolution Resources Rest Risk Rodent Scanning Scientist Sensory Receptors Services Software Tools Spectrum Analysis Statistical Data Interpretation Structure Students System Systems Development Talents Technical Expertise Technology Training Update animal imaging base behavioral phenotyping computer science data acquisition design human model image processing imaging modality imaging scientist insight instrument meetings neural correlate neural patterning neurochemistry neurodevelopment neuroimaging neuropathology nonhuman primate novel novel marker protocol development radiotracer relating to nervous system statistics tool white matter

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项目摘要

Waisman Center investigators study intellectual and developmental disabilities (IDD) through investigating the brain structure and function in both animal models and individuals exhibiting or at risk for these conditions. The Waisman Brain Imaging Core (BIC) provides all of the tools and services required for these investigations and includes facilities for magnetic resonance imaging (MRI), human positron emission tomography (PET), high- resolution PET for animal imaging, ancillary physiological recordings during imaging, and extensive software tools and training for image analysis. This facility occupies a key role in providing systems level neuroscience that lies at the interface between the neurodevelopment, behavioral and molecular levels of analysis. The specific aims for for the Brain Imaging Core are: Aim 1 to develop MRI, PET, fNIRS hardware, methodologies and software technologies for neuroimaging studies of normal development, atypical development, and neurodegeneration in both humans and animal models. The objectives of this aim encompass all of the available neuroimaging modalities and resources available for IDD investigators. We also provide access to a highly realistic MRI simulator to enable participants to acclimate to the procedures and rehearse the behavioral protocols that are used in scanning. Aim 2 to provide expertise and guidance for neuroimaging protocol development and experimental design to UW-Madison investigators for studying IDD populations and animal models. The objectives of this aim are to ensure IDD investigators have access to technical expertise in neuroimaging methods as they plan, initiate and conduct their research projects. The BIC is staffed with highly skilled imaging scientists with expertise in MRI pulse sequence design, PET neuroreceptor imaging, radiopharmaceutical development, rodent and nonhuman primate imaging and data analytics. Aim 3 to provide training and technical support for investigators and their staffs in the use of all of the imaging modalities in the BIC. The objectives of this aim include the conduct of courses and training workshops, regular technical updates at BIC monthly meetings and lab meetings of the participating PIs, specialized consultation with the staff and students of PIs, development of specialized scanning sequences and data acquisition protocols for novel applications and consultation and support in statistical analysis of imaging data. The overall activities and function of the BIC will be directed by the goal of enriching the UW neuroscience community to disseminate ideas, implement plans and train neuroimaging scientists for research in IDDs.

Waisman中心的研究人员通过研究智力和发育障碍（IDD）研究在动物模型和对这些疾病的风险中表现出或有风险的个体中的大脑结构和功能。这 Waisman脑成像核心（BIC）提供了这些调查所需的所有工具和服务包括用于磁共振成像（MRI），人类正电子发射断层扫描（PET）的设施动物成像的分辨率宠物，成像过程中的辅助生理记录和广泛的软件图像分析的工具和培训。该设施在提供系统级别的神经科学方面占有关键作用这在于神经发育，行为和分子分析水平之间的界面。具体用于大脑成像核心的目的是：目标1开发MRI，PET，FNIRS硬件，方法论和用于正常发展，非典型开发和神经影像研究的软件技术人类和动物模型中的神经变性。此目标的目标包括所有可用的 IDD调查人员可提供神经影像的方式和资源。我们还提供高度访问现实的MRI模拟器，使参与者能够适应程序并进行排练扫描中使用的协议。目标2为神经影像协议提供专业知识和指导 UW-Madison研究人员的开发和实验设计，用于研究IDD人群和动物型号。此目的的目标是确保IDD调查人员获得技术专长他们计划，启动和开展其研究项目的神经影像学方法。 BIC配备高度具有MRI脉冲序列设计专业知识的熟练成像科学家，PET神经感受器成像，放射药物的发展，啮齿动物和非人类灵长类动物成像和数据分析。瞄准3提供对调查人员及其员工的培训和技术支持，以使用所有成像方式 Bic。此目标的目标包括课程和培训研讨会的举动，定期技术更新在BIC月度会议和参与PI的实验室会议上，与工作人员进行专门咨询 PI的学生，开发专门的扫描序列和新颖的数据采集协议在成像数据的统计分析中的应用，咨询和支持。整体活动和 BIC的功能将由丰富UW神经科学社区传播的目标指导想法，实施计划并培训神经成像科学家进行IDD的研究。