Preclinical Models Core

临床前模型核心

基本信息

批准号：
10617220
负责人：
Tatiana Kisseleva
金额：
$ 26.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10617220
关键词：
Animal Experimentation Animal Model Animals Area Autopsy Biological Assay Biological Markers California Clinical Data Clinical Pathology Comparative Pathology Complement Consult Consultations Core Facility Data Analyses Development Digestive System Disorders Disease Doctor of Philosophy Experimental Designs Funding Gastrointestinal Diseases Gastrointestinal tract structure Gene Expression Genetic Predisposition to Disease Health Histology Histopathology Human Image Imaging Techniques Infection Inflammation Infrastructure Leadership Liver Liver diseases Medicine Methods Microscopy Mission Modeling Monitor National Institute of Diabetes and Digestive and Kidney Diseases Outcome Pathology Patients Pre-Clinical Model R24 Records Research Research Personnel Resources Role Scientist Services Stains Surveys System Techniques Training Translating Universities Veterinarians animal imaging comparative cost effective data acquisition disease phenotype experience functional genomics gastrointestinal system human disease in vivo in vivo imaging insight instrumentation lectures member microbiome research mouse model patient population pre-clinical pre-clinical research preclinical study programs prospective recruit repository research faculty sample fixation skills success tissue preparation veterinary science

项目摘要

Summary The Preclinical Models Core in the San Diego Digestive Diseases Research Center will provide access to animal models of gastrointestinal and liver disease for preclinical studies and will assist in characterizing disease activity prospectively and retrospectively in a comprehensive and uniform manner. The Core emanated out of core services provided by a past NIDDK-funded (R24) Mini-Center at the University of California, San Diego (UCSD). The approach to create the Preclinical Models Core is based on information from surveys of Center member needs, experience with the prior Mini-Center at UCSD, the broad expertise of Center members in digestive diseases research, and the insights of several of the Center members who have served as advisors or in leadership roles for other Silvio O. Conte Centers. The Core will provide resources in veterinary sciences and a technical infrastructure that enables animals to be studied comprehensively. The services will include consultation on the selection and interpretation of animal models of digestive diseases, ante-mortem imaging and post-mortem examination, including the development and interpretation of scoring systems by veterinarians trained in comparative pathology. Thus, the Core will truly be “preclinical” in that it will be modeling and evaluating disease with instrumentation also used in patients with the added advantage of the controlled manipulations that are possible in these models. The Core will be led by two experienced leaders with strong track records in applying animal models to basic and preclinical questions: Dr. Peter Ernst, a PhD veterinarian with extensive experience in managing Core facilities, will be the Core Director and focus on murine models of gastrointestinal disease and in vivo imaging. As the Core Co-Director, Dr. Tatiana Kisseleva will provide her extensive experience with animal models of liver disease. Furthermore, the Core will interact with and directly complement the Human Translational and Microbiomics and Functional Genomics Cores by being able to relate the imaging results, biomarkers and clinical data to specific outcomes in animal models and human disease. Thus, the Preclinical Models Core will benefit the investigators in the Center by providing reliable, cost-effective services that are coordinated with the investigators’ research and other Cores to facilitate and advance research related to the gastrointestinal tract and liver.

概括圣地亚哥消化疾病研究中心的临床前模型核心将提供访问进行胃肠道和肝病的动物模型进行临床前研究，并将有助于表征疾病活动以全面而统一的方式前瞻性和追溯。核心由过去的NIDDK资助（R24）迷你中心提供的核心服务发出加利福尼亚，圣地亚哥（UCSD）。创建临床前模型核心的方法基于信息从中心会员需求的调查，在UCSD的先前的小型中心经验中，消化系统疾病研究的中心成员，以及有几个中心成员的见解担任其他Silvio O. Conte中心的顾问或领导职务。核心将提供资源兽医科学和技术基础设施，可以彻底研究动物。这服务将包括有关消化疾病动物模型的选择和解释的咨询，验尸成像和验尸检查，包括评分的发展和解释受过比较病理学培训的兽医的系统。那就真正的核心将是“临床前” 用仪器对疾病进行建模和评估仪器，也用于患者中这些模型中可能的受控操作。核心将由两个经验丰富的领导人领导在将动物模型应用于基本和临床前问题时具有很强的记录：Peter Ernst博士，博士学位兽医在管理核心设施方面拥有丰富经验，将成为核心主任，并专注于胃肠道疾病和体内成像的鼠模型。作为核心联合导演，Tatiana Kisseleva博士将为她在肝病动物模型方面提供丰富的经验。此外，核心将相互作用与并直接补充人类翻译和微生物组和功能基因组学核心能够将成像结果，生物标志物和临床数据与动物模型中的特定结果联系起来和人类疾病。那就是临床前模型核心将通过提供可靠，具有成本效益的服务与研究人员的研究和其他核心协调促进并提高与胃肠道和肝脏有关的研究。