A network-based, mixed methods study to identify and support multiple overdose responders and inform overdose prevention interventions

一项基于网络的混合方法研究，旨在识别和支持多个药物过量反应者并为药物过量预防干预措施提供信息

• 批准号: 10590120
• 负责人: Karla D. Wagner
• 金额: $ 203.47万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590120
• 关键词: Address; American; Area; Behavior; COVID-19; Cessation of life; Characteristics; Clinical; Communities; Criminal Justice; Data; Drug usage; Drug user; Effectiveness; Emotional; Ensure; Epidemic; Exposure to; Family member; Fentanyl; Friends; Funding; Geography; Goals; Harm Reduction; Health; Individual; Intervention; Investigation; Investments; Laws; Lead; Life; Measurement; Methods; Modeling; Naloxone; National Institute of Drug Abuse; Network-based; Nevada; Overdose; Personal Satisfaction; Persons; Pharmaceutical Preparations; Policies; Property; Public Health; Research; Resources; Role; Savings; Services; Social Network; Stimulant; Stress; Testing; Time; Training; Training Support; Trauma; Work; acceptability and feasibility; base; behavioral response; burnout; combat; contextual factors; emergency service responder; empowered; experience; improved; member; opioid overdose; overdose death; overdose education; overdose prevention; overdose risk; preventive intervention; programs; recruit; resilience; response; social; social structure; substance use

07. Project Summary The goal of this proposal is to identify strategies to improve the effectiveness and sustainability of overdose education and naloxone distribution (OEND) programs for people who use drugs (PWUD). Research suggests that some PWUD enthusiastically take up the role of “overdose responder”, responding to multiple overdoses over relatively short periods of time. Others, however, respond to few or no overdoses. We seek to determine the individual, social network, and contextual factors that influence overdose response behavior, with the goal of improving support for PWUD who respond to multiple overdoses and identifying intervention targets to improve the overall capacity of PWUD networks to respond to overdoses among their members. To answer these questions, we propose a longitudinal mixed methods study with 300 PWUDs recruited in Reno, Nevada (an understudied Western region), to address the following aims: 1. Identify the individual, social network, and contextual characteristics of OD responders (relative to those who do not carry or do not use the naloxone they have), including substance use behaviors, size and composition of social networks, personal resilience factors, and geographic and socio-structural factors. 2. Qualitatively describe the positive and negative experiences of responding to ODs, and identify (a) the support or services needed by PWUDs to sustainably respond to ODs in their communities, and (b) the barriers to response among those who do not respond or stop responding. 3. Assess feasibility and acceptability of interventions to improve sustainability and wellbeing of responders, and increase initiation of response behavior among non-responders. Supplemental Aim: Collect quantitative and qualitative data to inform an agent-based model (ABM) of PWUD to test how different OEND program delivery strategies could lead to reductions in fatal OD rates.

07。项目摘要 该建议的目的是确定提高过量效力和可持续性的策略 用于使用药物的人（PWUD）的教育和纳洛酮分布（OEND）计划。研究建议 一些人热情地扮演“过量响应者”的角色，回应多种过量 在相对较短的时间内。但是，其他人对少量或没有过量的反应。我们试图确定 影响过量反应行为的个人，社交网络和上下文因素，其目标 改善对PWUD的支持，他们对多种药物的反应并确定干预目标 提高PWUD网络的总体能力以应对其成员中的过量剂量。 为了回答这些问题，我们提出了一项纵向混合方法研究，并在 内华达州里诺（一个了解的西部地区），以解决以下目的： 1。确定OD响应者的个人，社交网络和上下文特征（相对于那些 谁不携带或不使用其拥有的纳洛酮），包括药物使用行为，大小和 社交网络，个人弹性因素以及地理和社会结构因素的组成。 2。定性地描述对OD的反应的积极和负面经历，并确定（a） Pwuds所需的支持或服务可持续地响应其社区的OD，以及（b） 那些不回应或停止回应的人之间应对障碍。 3.评估干预措施的可行性和可接受性，以提高响应者的可持续性和福祉， 并增加了非反应者之间反应行为的主动性。 补充目的：收集定量和定性数据，以告知基于代理的PWUD模型（ABM） 测试不同的OEND计划交付策略如何导致致命的OD率降低。