Training in Neurodegenerative Diseases

神经退行性疾病培训

• 批准号: 10614554
• 负责人: Xiongwei Zhu
• 金额: $ 16.11万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614554
• 关键词: Neurodegenerative Disorders; Training

As our population ages, the incidence of Alzheimer disease (AD), Parkinson disease (PD), Amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases continues to rise, and the need for successful translational research programs is imperative to maintain a healthy aging population and reduce the burden of increased health care costs on society. While much understanding of neurodegenerative mechanisms have been gained over the years of investigation, not much had been successfully translated into patient treatment which calls for deeper appreciation of these diseases through clinical perspective in the future neurodegeneration investigators. The Neurodegeneration Training Program (NTP) has been designed for selected students to provide rigorous pre-doctoral scientific training in the field of neurodegeneration along with extensive clinical exposure. The goal of the NTP is to provide trainees with the fundamental skills necessary for outstanding careers in neurodegeneration research, together with an appreciation of the challenges and complexity of diagnosing and treating neurodegenerative diseases in the clinical setting. The NTP emphasizes rigorous PHD training in fundamental aspects of neurodegeneration and mechanisms of diseases involving neurodegeneration and clinical perspectives through classroom teaching, neurodegeneration-related laboratory research and mentored neurodegenerative clinical experiences combined with educational forums that address important topics in clinical and translational neurodegeneration research. A competitive pool of trainees will combine with 19 outstanding faculty in state-of –the-art facilities to investigate a wide range of neurodegeneration-related topics spanning research areas such as molecular genetics, protein structure, cell and molecular biology and in vitro and in vivo models of disease. The NTP promotes collaboration between departments and schools at Case Western Reserve University, particularly the School of Medicine, and with its affiliated institutions in the Cleveland area: University Hospitals Cleveland Medical Center (UHCMC), and the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute). All of these institutions are within walking distance of each other and this rich training environment enjoys very active basic science and clinical activities. The updated curriculum provides a solid foundation for neurodegeneration research. The well-received mentored neurodegenerative clinical experience has been expanded to include six renowned clinicians enabling direct interaction with patients and caregivers in several different clinical centers close to CWRU campus providing motivation to the trainees to produce advances in disease diagnosis and therapies. The recently added career development and professional enrichment module ensures better preparedness of our trainees to achieve their desired career goals. Together, NTP training will provide trainees a solid foundation for an outstanding neurodegeneration-related career.

随着我们人口的年龄，阿尔茨海默氏病（AD），帕金森病（PD）的事件，肌萎缩症后来 硬化症（ALS）和其他相关的神经退行性疾病继续增加，需要成功 翻译研究计划必须保持健康的老龄化人群，并减少燃烧 增加了社会的医疗保健成本。尽管对神经退行性机制有很多了解 在多年来的调查中获得了，并没有成功地转化为患者治疗 这要求将来通过临床观点深入了解这些疾病 神经变性研究者。神经退行性培训计划（NTP）是为 选定的学生在神经退行性领域提供严格的博士前科学培训以及 广泛的临床暴露。 NTP的目标是为受训者提供必要的基本技能 对于神经退行性研究的杰出职业，以及对挑战和 诊断和治疗临床环境中神经退行性疾病的复杂性。 NTP强调 在神经退行性基本方面的严格博士培训和涉及疾病的机制 神经变性和临床视角通过课堂教学，与神经变性有关 实验室研究和修补神经退行性临床经验以及教育论坛 该介绍了临床和翻译神经变性研究中的重要主题。 有竞争性的学员将与19位杰出教职员工结合在一起 研究跨越研究领域的广泛的神经变性相关主题，例如分子 遗传学，蛋白质结构，细胞和分子生物学以及体外和体内疾病模型。 NTP 促进Case Western Reserve University的系与学校之间的合作，特别是 医学院及其在克利夫兰地区的会员机构：克利夫兰大学医院 医疗中心（UHCMC）和克利夫兰诊所基金会（CCF，包括勒纳研究所）。 所有这些机构都在彼此的步行距离之内，这种丰富的培训环境非常享受 活跃的基础科学和临床活动。更新的课程为 神经变性研究。良好的修饰神经退行性临床经验已经 扩展到包括六位著名的临床医生，可以与患者和看护人直接互动 靠近CWRU校园的不同临床中心为培训提供动力，以取得进步 疾病诊断和疗法。最近添加的职业发展和专业丰富模块 确保我们的学员更好地准备自己的职业目标。 NTP培训将在一起 为学员提供与神经变性相关的杰出职业的坚实基础。