Training in Neurodegenerative Diseases

神经退行性疾病培训

• 批准号: 10614554
• 负责人: Xiongwei Zhu
• 金额: $ 16.11万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10614554
• 关键词: Neurodegenerative Disorders; Training

As our population ages, the incidence of Alzheimer disease (AD), Parkinson disease (PD), Amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases continues to rise, and the need for successful translational research programs is imperative to maintain a healthy aging population and reduce the burden of increased health care costs on society. While much understanding of neurodegenerative mechanisms have been gained over the years of investigation, not much had been successfully translated into patient treatment which calls for deeper appreciation of these diseases through clinical perspective in the future neurodegeneration investigators. The Neurodegeneration Training Program (NTP) has been designed for selected students to provide rigorous pre-doctoral scientific training in the field of neurodegeneration along with extensive clinical exposure. The goal of the NTP is to provide trainees with the fundamental skills necessary for outstanding careers in neurodegeneration research, together with an appreciation of the challenges and complexity of diagnosing and treating neurodegenerative diseases in the clinical setting. The NTP emphasizes rigorous PHD training in fundamental aspects of neurodegeneration and mechanisms of diseases involving neurodegeneration and clinical perspectives through classroom teaching, neurodegeneration-related laboratory research and mentored neurodegenerative clinical experiences combined with educational forums that address important topics in clinical and translational neurodegeneration research. A competitive pool of trainees will combine with 19 outstanding faculty in state-of –the-art facilities to investigate a wide range of neurodegeneration-related topics spanning research areas such as molecular genetics, protein structure, cell and molecular biology and in vitro and in vivo models of disease. The NTP promotes collaboration between departments and schools at Case Western Reserve University, particularly the School of Medicine, and with its affiliated institutions in the Cleveland area: University Hospitals Cleveland Medical Center (UHCMC), and the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute). All of these institutions are within walking distance of each other and this rich training environment enjoys very active basic science and clinical activities. The updated curriculum provides a solid foundation for neurodegeneration research. The well-received mentored neurodegenerative clinical experience has been expanded to include six renowned clinicians enabling direct interaction with patients and caregivers in several different clinical centers close to CWRU campus providing motivation to the trainees to produce advances in disease diagnosis and therapies. The recently added career development and professional enrichment module ensures better preparedness of our trainees to achieve their desired career goals. Together, NTP training will provide trainees a solid foundation for an outstanding neurodegeneration-related career.

随着人口老龄化，阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症的发病率 硬化症（ALS）和其他相关的神经退行性疾病持续增加，并且需要成功 转化研究计划对于维持人口健康老龄化和减轻人口负担至关重要 尽管人们对神经退行性机制有了更多的了解，但社会的医疗保健成本却增加了。 经过多年的调查，取得的成果并没有多少成功转化为患者治疗 这需要未来从临床角度更深入地认识这些疾病 神经退行性疾病研究人员设计了神经退行性疾病培训计划 (NTP)。 选定的学生在神经退行性疾病领域提供严格的博士前科学培训 NTP 的目标是为学员提供广泛的临床经验。 表彰其在神经退行性疾病研究领域的杰出职业生涯，以及对挑战和认识的认识 NTP 强调临床环境中诊断和治疗神经退行性疾病的复杂性。 在神经退行性变的基本方面和涉及疾病的机制方面进行严格的博士培训 通过课堂教学、神经变性相关的神经变性和临床观点 实验室研究和指导的神经退行性临床经验与教育论坛相结合 解决临床和转化神经变性研究的重要主题。 具有竞争力的学员库将与 19 名优秀教师在最先进的设施中相结合， 研究广泛的神经退行性疾病相关主题，涵盖分子等研究领域 遗传学、蛋白质结构、细胞和分子生物学以及疾病的体外和体内模型。 促进凯斯西储大学各院系之间的合作，特别是 医学院及其在克利夫兰地区的附属机构：克利夫兰大学医院 医疗中心 (UHCMC) 和克利夫兰诊所基金会 (CCF，包括勒纳研究所)。 所有这些机构都在步行距离之内，这种丰富的培训环境非常适合 更新的课程为积极的基础科学和临床活动奠定了坚实的基础。 神经退行性疾病研究广受好评。 扩大到包括六位知名倡导者，能够在多个领域与患者和护理人员直接互动 CWRU 校园附近的不同临床中心为学员提供动力以取得进步 最近添加的职业发展和专业丰富模块。 NTP 培训将确保我们的学员为实现他们期望的职业目标做好更好的准备。 为学员提供与神经退行性疾病相关的杰出职业生涯的坚实基础。