Botanical Approaches to Combat Metabolic Syndrome

对抗代谢综合症的植物方法

基本信息

批准号：
10615717
负责人：
PHILLIP J BRANTLEY
金额：
$ 40.29万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10615717
关键词：
Botanicals Metabolic syndrome combat

项目摘要

Project Summary This application requests a second renewal for our Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) entitled “Training in Botanical Approaches to Combat Metabolic Syndrome.” This training program is a collaborative effort between the Pennington Biomedical Research Center of Louisiana State University and the Departments of Plant Biology and Food Science at Rutgers University. The objective of this program is to train the highest caliber of postdoctoral fellows to become productive scientists integrating biomedical research methods and botanical discovery research with the capability of establishing successful scientific careers in academia, academic medicine, governmental agencies, and in the private sector. Metabolic syndrome is prevalent, poses a significant threat to public health, and it is characterized by the presence of co-existing traditional risk factors for cardiovascular disease (e.g. hypertension, dyslipidemia, glucose intolerance, obesity and insulin resistance). Preventative approaches for metabolic syndrome often primarily focus on lifestyle interventions. However, maintenance of lifestyle changes over time is poor. Thus, nutritional supplementation with botanicals that effectively address pathogenic mechanisms, combined with the acceptance and widespread use of supplements by the general public, present an attractive, novel and potentially effective approach to combat metabolic syndrome. Therefore, research training provided by this T32 will be directed toward evaluating the interactions between botanical characterization and the molecular, genetic, and physiologic approaches to achieve the ultimate goal of understanding how botanicals can contribute to health and normal tissue function. The program emphasizes hands on research training in an environment that encourages and facilitates transdisciplinary research and team science. The program will also benefit from the synergy and cutting-edge technologies of the NCCIH-sponsored Botanical Dietary Supplements Research Center (BDSRC) also focused on botanical supplements and metabolic syndrome. This integration between the T32 and the BDSRC provides trainees the opportunity to pursue studies with investigators whose interest span all organ systems impacted by obesity and metabolic syndrome. Since it began in 2009, this T32 program has graduated 15 postdocs who have remained in research-oriented careers and have acquired 30 grants (8 from NIH). Eleven graduates are now in academia and four are in industry. Seven postdocs are still in training. In total, this program’s 22 trainees have published 124 papers on their T32 projects including 66 first author papers. We are requesting 7 full-time postdoctoral trainee positions per year (5 at Pennington Biomedical and 2 at Rutgers) for the next five-year grant cycle (2020-2025). Trainees will be supported for two to three years. Each postdoctoral fellow will be encouraged to develop interdisciplinary research efforts to understand the effects of botanicals on components of metabolic syndrome.

项目概要此申请要求第二次续展我们的露丝·L·基尔施斯坦国家研究服务奖 (NRSA) 机构研究培训补助金 (T32)，题为“植物学方法对抗培训” 该培训计划是彭宁顿生物医学中心的合作成果。路易斯安那州立大学研究中心和植物生物学与食品科学系罗格斯大学该项目的目标是培养最优秀的博士后研究员。将生物医学研究方法和植物发现研究与在学术界、学术医学、政府机构建立成功的科学事业的能力，在私营部门，代谢综合征很普遍，对公共健康构成重大威胁。其特点是同时存在心血管疾病的传统危险因素（例如高血压、血脂异常、葡萄糖不耐受、肥胖和胰岛素抵抗）。综合症通常主要集中在生活方式干预上，然而，生活方式的维持会随着时间的推移而改变。因此，有效解决致病机制的植物性营养补充剂，结合公众对补充剂的接受和广泛使用，呈现出有吸引力的、因此，提供了对抗代谢综合征的新颖且潜在有效的方法。通过这个 T32 将直接评估植物学特征和分子、遗传和生理学方法，以实现了解植物药如何发挥作用的最终目标有助于健康和正常组织功能。该计划强调实践研究培训。该计划还将创造鼓励和促进跨学科研究和团队科学的环境。受益于 NCCIH 赞助的植物膳食补充剂的协同作用和尖端技术研究中心（BDSRC）还专注于植物补充剂和代谢综合征的这种整合。 T32 和 BDSRC 之间的合作为学员提供了与研究人员一起进行研究的机会，自 2009 年开始，T32 的兴趣遍及受肥胖和代谢综合征影响的所有器官系统。该项目已毕业 15 名博士后，他们一直从事研究型职业，并获得了 30 资助（其中 8 名来自 NIH），目前有 11 名毕业生在学术界工作，7 名博士后仍在工业界工作。总共有 22 名学员在 T32 项目上发表了 124 篇论文，其中 66 篇是第一名。我们每年需要 7 个全职博士后实习生职位（5 个在 Pennington Biomedical）。罗格斯大学 2 名）在下一个五年资助周期（2020-2025 年）将支持 2 至 3 名受训人员。将鼓励每位博士后开展跨学科研究工作以了解情况。植物药对代谢综合征成分的影响。

项目成果

期刊论文数量（118）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Acute Exercise Increases NK Cell Mitochondrial Respiration and Cytotoxicity against Triple-Negative Breast Cancer Cells under Hypoxic Conditions.

DOI：
10.1249/mss.0000000000003250
发表时间：
2023-12-01
期刊：
Medicine and science in sports and exercise
影响因子：
4.1
作者：
通讯作者：

Stable binding of alternative protein-enriched food matrices with concentrated cranberry bioflavonoids for functional food applications.

DOI：
10.1021/jf401627m
发表时间：
2013-07-17
期刊：
Journal of agricultural and food chemistry
影响因子：
6.1
作者：
Grace MH;Guzman I;Roopchand DE;Moskal K;Cheng DM;Pogrebnyak N;Raskin I;Howell A;Lila MA
通讯作者：
Lila MA

Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver.

DOI：
10.1186/s12986-016-0075-0
发表时间：
2016
期刊：
Nutrition & metabolism
影响因子：
4.5
作者：
Ghosh S;Kruger C;Wicks S;Simon J;Kumar KG;Johnson WD;Mynatt RL;Noland RC;Richards BK
通讯作者：
Richards BK

Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo.