Botanical Approaches to Combat Metabolic Syndrome

对抗代谢综合症的植物方法

• 批准号: 10399411
• 负责人: PHILLIP J BRANTLEY
• 金额: $ 59.42万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10399411
• 关键词: Botanicals; Metabolic syndrome; combat

Project Summary This application requests a second renewal for our Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) entitled “Training in Botanical Approaches to Combat Metabolic Syndrome.” This training program is a collaborative effort between the Pennington Biomedical Research Center of Louisiana State University and the Departments of Plant Biology and Food Science at Rutgers University. The objective of this program is to train the highest caliber of postdoctoral fellows to become productive scientists integrating biomedical research methods and botanical discovery research with the capability of establishing successful scientific careers in academia, academic medicine, governmental agencies, and in the private sector. Metabolic syndrome is prevalent, poses a significant threat to public health, and it is characterized by the presence of co-existing traditional risk factors for cardiovascular disease (e.g. hypertension, dyslipidemia, glucose intolerance, obesity and insulin resistance). Preventative approaches for metabolic syndrome often primarily focus on lifestyle interventions. However, maintenance of lifestyle changes over time is poor. Thus, nutritional supplementation with botanicals that effectively address pathogenic mechanisms, combined with the acceptance and widespread use of supplements by the general public, present an attractive, novel and potentially effective approach to combat metabolic syndrome. Therefore, research training provided by this T32 will be directed toward evaluating the interactions between botanical characterization and the molecular, genetic, and physiologic approaches to achieve the ultimate goal of understanding how botanicals can contribute to health and normal tissue function. The program emphasizes hands on research training in an environment that encourages and facilitates transdisciplinary research and team science. The program will also benefit from the synergy and cutting-edge technologies of the NCCIH-sponsored Botanical Dietary Supplements Research Center (BDSRC) also focused on botanical supplements and metabolic syndrome. This integration between the T32 and the BDSRC provides trainees the opportunity to pursue studies with investigators whose interest span all organ systems impacted by obesity and metabolic syndrome. Since it began in 2009, this T32 program has graduated 15 postdocs who have remained in research-oriented careers and have acquired 30 grants (8 from NIH). Eleven graduates are now in academia and four are in industry. Seven postdocs are still in training. In total, this program’s 22 trainees have published 124 papers on their T32 projects including 66 first author papers. We are requesting 7 full-time postdoctoral trainee positions per year (5 at Pennington Biomedical and 2 at Rutgers) for the next five-year grant cycle (2020-2025). Trainees will be supported for two to three years. Each postdoctoral fellow will be encouraged to develop interdisciplinary research efforts to understand the effects of botanicals on components of metabolic syndrome.

项目摘要 该申请要求我们的露丝·柯希斯坦国家研究服务奖第二次续订 （NRSA）机构研究培训补助金（T32）题为“植物学方法的培训 代谢综合征。 路易斯安那州立大学研究中心和植物生物学和食品科学系 罗格斯大学。该计划的目的是训练最高的博士后研究员成为 生产科学家将生物医学研究方法和植物发现研究整合在一起 在学术界，学术医学，政府机构中建立成功的科学职业的能力， 并在私营部门。代谢综合征普遍存在，对公共卫生构成重大威胁，这是 其特征是存在共存传统的心血管疾病风险因素（例如高血压， 血脂异常，葡萄糖肠道，肥胖和胰岛素抵抗）。代谢的预防方法 综合征通常主要关注生活方式干预措施。但是，随着时间的推移，生活方式的维护变化 是贫穷的。这是用植物学有效地解决致病机制的植物学补充的营养 加上公众对补充剂的接受和宽度的使用，提出了一个有吸引力的 新颖且潜在的有效方法来对抗代谢综合征。因此，提供的研究培训 通过该T32，将针对评估植物表征与 分子，遗传和物理方法，以实现理解植物体的最终目标 可以有助于健康和正常的组织功能。该计划强调动手进行研究培训 鼓励和促进跨学科研究和团队科学的环境。该程序也将 受益于NCCIH赞助的植物饮食补充剂的协同和尖端技术 研究中心（BDSRC）也关注植物补充剂和代谢综合征。这个整合 在T32和BDSRC之间，培训提供了与调查人员进行研究的机会 兴趣跨越所有受肥胖和代谢综合征影响的器官系统。自2009年开始以来，这个T32 计划毕业了15个博士后，他们一直从事研究为导向的职业，并获得了30个 赠款（NIH 8）。现在有11名毕业生在学术界，有4位在行业中。七个博士后仍在 训练。该计划的22名学员总共发表了124篇有关其T32项目的论文 作者论文。我们要求每年7个全职博士后学员职位（5个在Pennington BioMedical 在罗格斯（Rutgers）和2个）将在接下来的五年赠款周期（2020-2025）。学员将获得两到三个 年。每个博士后研究员都将被鼓励开展跨学科研究工作以了解 植物对代谢综合征成分的影响。