Pathogenesis, Targeted Therapeutics, and New Vaccines for Childhood Disease

儿童疾病的发病机制、靶向治疗和新疫苗

• 批准号: 10613453
• 负责人: Michael R. DeBaun
• 金额: $ 44万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-08 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613453
• 关键词: Academic Medical Centers; Aptitude; Area; Cancer Biology; Childhood; Collaborations; Communicable Diseases; Core Facility; Coupled; Diabetes Mellitus; Disease; Elements; Environment; Evaluation; Faculty; Funding; Future; Genetic Medicine; Genomic medicine; Goals; Grant; Group Meetings; Health system; Heart Diseases; Hospitals; Institution; International; Leadership; Learning; Lung diseases; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Metabolism; Molecular; Obesity; Pathogenesis; Physicians; Positioning Attribute; Research; Research Personnel; Research Project Grants; Resources; Scientist; Time; Training; Training Programs; Underrepresented Minority; United States National Institutes of Health; cardiogenesis; career; career development; collaborative environment; distraction; emerging pathogen; laboratory facility; lung development; medical schools; meetings; multidisciplinary; nervous system disorder; next generation; novel vaccines; pediatric department; pediatrician; programs; research and development; research facility; targeted treatment; therapeutic target; therapeutic vaccine; training opportunity; translational physician

Project Summary The goal of this renewal application is to continue our K12 training program for early career pediatricians with both the aptitude and passion to become the next generation of basic and translational physician scientists. The results of our first funding cycle have been excellent, and lessons learned are incorporated to further strengthen the program. The overarching theme for the program is elucidation of the molecular and cellular pathogenesis of childhood diseases, leading to identification of therapeutic targets. Our focus is career development in the following areas where Vanderbilt has internationally recognized programs of discovery combined with a record of excellence in research mentorship: 1) Lung Disease and Development, 2) Heart Disease and Development; 3) Obesity and Metabolism (including diabetes) 4) Neurological Disorders; 5) Cancer Biology, 6) Genetics and Genomic Medicine, and 7) Infectious Diseases, including emerging pathogens. The program offers an integrated pediatric department and medical school training program for four pediatric K12 scholars to receive up to three years of support that includes intense scientific mentorship and personalized career development. The scholars will have access to a cadre of well-established faculty including 33 carefully selected senior investigators, all with sustained NIH funding coupled with a successful track record of mentoring early career scholars. Also, we have selected 8 pediatric ‘next generation mentors’, with K or early R01 funding that will be well positioned for full mentorship in the future. The Department of Pediatrics is fully integrated into the Vanderbilt School of Medicine and health system, a leading NIH funded academic medical center. All departments, hospitals, research laboratories and core facilities reside on a single campus offering an integrated research environment for scholars. Through multiple training grants, there is a strong pipeline of future K12 scholars. Program leadership will also conduct a national search to identify a group of K12 scholars, including underrepresented minorities, that will thrive in this collaborative environment. Each scholar will have an individualized training program developed by the PI and training directors in collaboration with a multidisciplinary mentorship team and will be supported by a broad array of institutional and departmental resources. The primary focus for each scholar will be their mentored research project, but they will have opportunities to participate in an array of training opportunities to support their research and career development goals. To avoid distraction from research time, we will carefully define required activities from optional program opportunities. Required elements include weekly attendance at lab meetings and with their primary mentor, monthly group meetings with program leaders, six- monthly scholar oversight committee meetings, and annual evaluations of scholars and program. They will also have confidential face-to-face meetings with two outside advisors (Drs. Arnold Strauss and George Dover). These plans provide an optimal environment for developing the next generation of pediatric physician scientists.

项目摘要 此续签申请的目的是继续为早期职业儿科医生的K12培训计划 成为下一代基本和翻译的物理科学家的能力和热情。这 我们的第一个融资周期的结果非常出色，并且学习了经验教训以进一步加强 该程序。该程序的总体主题是阐明分子和细胞发病机理 儿童疾病，导致治疗靶标的鉴定。我们的重点是职业发展 范德比尔特（Vanderbilt）拥有国际认可的发现计划以及记录的领域 卓越研究心态：1）肺部疾病与发育，2）心脏病与发育； 3）肥胖和代谢（包括糖尿病）4）神经系统疾病； 5）癌症生物学，6）遗传学和 基因组医学和7）传染病，包括新兴病原体。该程序提供了一个集成的 针对四个儿科K12学者的儿科部门和医学院培训计划可获得多达三个 多年的支持，包括激烈的科学心态和个性化的职业发展。学者 将可以进入一名成熟的教职员工，其中包括33位精心挑选的高级调查员 持续的NIH资金以及成功的早期职业学者的成功记录。另外，我们有 选定的8个儿科“下一代导师”，具有K或早期R01资金，可以很好地适应 未来的遗产。儿科部已完全纳入范德比尔特医学院 和卫生系统，领先的NIH资助的学术医疗中心。所有部门，医院，研究 实验室和核心设施居住在一个校园中，为综合研究环境提供 学者。通过多个培训补助金，有很强的未来K12学者的渠道。计划领导 还将进行全国搜索，以确定一组K12学者，包括代表性不足的少数民族， 这将在这个协作环境中蓬勃发展。每所学校都会有个性化的培训计划 由PI和培训导演与多学科心态团队合作开发，将是 得到一系列机构和部门资源的支持。每所学校的主要重点将 成为他们的指导研究项目，但他们将有机会参加一系列培训 支持他们的研究和职业发展目标的机会。为了避免研究时间分散注意力， 我们将仔细定义可选计划机会所需的活动。所需的元素包括每周 参加实验室会议以及其主要导师，每月与计划负责人的小组会议，六 每月学校监督委员会会议，以及对学者和计划的年度评估。他们也会 与两名外部顾问（Arnold Strauss博士和George Dover博士）进行机密面对面的会议。 这些计划为发展下一代儿科物理科学家提供了最佳的环境。