Pathogenesis, Targeted Therapeutics, and New Vaccines for Childhood Disease

儿童疾病的发病机制、靶向治疗和新疫苗

基本信息

批准号：
10225917
负责人：
STEVEN A. WEBBER
金额：
$ 44万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-02-08 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10225917
关键词：
Academic Medical Centers Aptitude Area Cancer Biology Childhood Collaborations Columbidae Communicable Diseases Core Facility Coupled Diabetes Mellitus Disease Elements Environment Evaluation Faculty Funding Future Genetic Medicine Genomic medicine Goals Grant Group Meetings Health system Heart Diseases Hospitals International Laboratory Research Leadership Lung diseases Mentors Mentorship Metabolism Molecular NCI Scholars Program Obesity Pathogenesis Physicians Positioning Attribute Research Research Personnel Research Project Grants Resources SECTM1 gene Scientist Time Training Training Programs Underrepresented Minority United States National Institutes of Health cardiogenesis career career development collaborative environment distraction emerging pathogen laboratory facility lung development medical schools meetings multidisciplinary nervous system disorder next generation novel vaccines pediatric department pediatrician programs research and development targeted treatment therapeutic target therapeutic vaccine training opportunity translational physician

项目摘要

Project Summary The goal of this renewal application is to continue our K12 training program for early career pediatricians with both the aptitude and passion to become the next generation of basic and translational physician scientists. The results of our first funding cycle have been excellent, and lessons learned are incorporated to further strengthen the program. The overarching theme for the program is elucidation of the molecular and cellular pathogenesis of childhood diseases, leading to identification of therapeutic targets. Our focus is career development in the following areas where Vanderbilt has internationally recognized programs of discovery combined with a record of excellence in research mentorship: 1) Lung Disease and Development, 2) Heart Disease and Development; 3) Obesity and Metabolism (including diabetes) 4) Neurological Disorders; 5) Cancer Biology, 6) Genetics and Genomic Medicine, and 7) Infectious Diseases, including emerging pathogens. The program offers an integrated pediatric department and medical school training program for four pediatric K12 scholars to receive up to three years of support that includes intense scientific mentorship and personalized career development. The scholars will have access to a cadre of well-established faculty including 33 carefully selected senior investigators, all with sustained NIH funding coupled with a successful track record of mentoring early career scholars. Also, we have selected 8 pediatric ‘next generation mentors’, with K or early R01 funding that will be well positioned for full mentorship in the future. The Department of Pediatrics is fully integrated into the Vanderbilt School of Medicine and health system, a leading NIH funded academic medical center. All departments, hospitals, research laboratories and core facilities reside on a single campus offering an integrated research environment for scholars. Through multiple training grants, there is a strong pipeline of future K12 scholars. Program leadership will also conduct a national search to identify a group of K12 scholars, including underrepresented minorities, that will thrive in this collaborative environment. Each scholar will have an individualized training program developed by the PI and training directors in collaboration with a multidisciplinary mentorship team and will be supported by a broad array of institutional and departmental resources. The primary focus for each scholar will be their mentored research project, but they will have opportunities to participate in an array of training opportunities to support their research and career development goals. To avoid distraction from research time, we will carefully define required activities from optional program opportunities. Required elements include weekly attendance at lab meetings and with their primary mentor, monthly group meetings with program leaders, six- monthly scholar oversight committee meetings, and annual evaluations of scholars and program. They will also have confidential face-to-face meetings with two outside advisors (Drs. Arnold Strauss and George Dover). These plans provide an optimal environment for developing the next generation of pediatric physician scientists.

项目概要此更新申请的目标是继续我们针对早期职业儿科医生的 K12 培训计划成为下一代基础和转化医学科学家的能力和热情。我们的第一个融资周期的结果非常出色，并吸取了经验教训以进一步加强该计划的首要主题是阐明分子和细胞发病机制。我们的重点是儿童疾病的职业发展。范德比尔特在以下领域拥有国际公认的发现计划和记录卓越的研究指导：1) 肺病与发育，2) 心脏病与发育； 3) 肥胖和代谢（包括糖尿病） 4) 神经系统疾病；5) 癌症生物学，6) 遗传学和基因组医学，以及 7) 传染病，包括新出现的病原体该计划提供综合的治疗。儿科和医学院培训计划，为四名儿科 K12 学者提供最多三名多年的支持，包括深入的科学指导和个性化的职业发展。将有机会接触到一支由完善的教职人员组成的骨干队伍，其中包括 33 名精心挑选的高级研究人员，他们都拥有此外，我们还拥有持续的 NIH 资助以及指导早期职业学者的成功记录。选择 8 名儿科“下一代导师”，并获得 K 或早期 R01 资金，这将使其能够充分利用未来，儿科将完全融入范德比尔特医学院。和卫生系统，领先的 NIH 资助的学术医疗中心所有部门、医院、研究。实验室和核心设施位于一个校园内，为学生提供综合研究环境通过多项培训资助，未来 K12 学者项目的领导力不断增强。还将进行全国性搜寻，以确定一组 K12 学者，包括代表性不足的少数族裔，每位学者都将拥有个性化的培训计划。由 PI 和培训主管与多学科指导团队合作开发，并将每位学者的主要关注点将得到广泛的机构和部门资源的支持。是他们指导的研究项目，但他们将有机会参加一系列培训支持他们的研究和职业发展目标的机会，以避免分散研究时间，我们将从可选的计划机会中仔细定义所需的活动，包括每周。参加实验室会议并与他们的主要导师一起参加，每月与项目负责人举行小组会议，六- 他们还将每月召开学者监督委员会会议，以及对学者和项目进行年度评估。与两位外部顾问（阿诺德·施特劳斯博士和乔治·多佛博士）进行保密的面对面会议。这些计划为培养下一代儿科医生科学家提供了最佳环境。