The long-term impact of light intervention on sleep physiology and cognition in mild cognitive impairment

光干预对轻度认知障碍患者睡眠生理和认知的长期影响

基本信息

批准号：
10612909
负责人：
Mariana Gross Figueiro
金额：
$ 72.08万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612909
关键词：
Adult Aging Agitation Alzheimer&apos s Disease Alzheimer&apos s disease caregiver Alzheimer&apos s disease patient American Assisted Living Facilities Biometry Caregiver Burden Caregivers Circadian Rhythms Circadian desynchrony Clinical Cognition Cognitive Coupling Data Data Analyses Dementia Development Disease Disease Progression Elderly Electroencephalography Electrophysiology (science)Epidemiology Event Excessive Daytime Sleepiness Exposure to Frequencies Goals Grant Home Human Impaired cognition Independent Living Intervention Light Link Long-Term Effects Measures Mediating Medical center Memory Memory impairment Mental Depression Methods Neurologist Nursing Homes Patients Performance Persons Phase Phototherapy Pittsburgh Sleep Quality Index Placebo Control Process Public Health Schools Quality of life Questionnaires Randomized Research Risk Sleep Sleep Architecture Sleep Disorders Societies Somnambulism Study Subject System Technology Testing Time Visual Work actigraphy arm circadian cognitive performance cognitive process cognitive task cohort design dosage follow-up healthy aging improved improvement on sleep light effects long term memory member memory consolidation meter mild cognitive impairment neural non rapid eye movement pathological aging post intervention prevent professor recruit response skills sleep physiology sleep spindle social statistics young adult

项目摘要

Project Summary/Abstract Data suggest that approximately 40% of the 5.5+ million older Americans with Alzheimer's disease (AD) suffer from severe dysfunction of sleep–wake and circadian systems. In people with mild cognitive impairment (MCI), which is an “at risk” or potential prodromal stage of dementia, sleep-wake disturbance is evident in up to 60% of patients. Sleep is critical for healthy cognitive processing in older adults. This application proposes to investigate the impact of a long-term lighting treatment on sleep physiology and sleep-dependent cognitive processes in MCI and mild AD patients. We hypothesize that a long-term (6-month) lighting intervention technology (LIT) designed to promote circadian entrainment will improve sleep and, thus cognition. We also hypothesize that LIT will improve depression and quality of life (QoL). In a single-arm, randomized, placebo-controlled (non-active comparison lighting intervention), between-subjects study, we will investigate the effect of a 6-month exposure to LIT (with a “pure follow-up period” of 3 months post-intervention) on: (1) objective measures of sleep (EEG, actigraphy), (2) subjective measures of sleep (Pittsburgh Sleep Quality Index), (3) cognition (working and long-term memory), and (4) depression and QoL (questionnaires). Our scientific premise is that sleep spindles, and timing of spindles relative to SO, are critical components of an interaction between electrophysiological events that provide a mechanistic explanation for memory consolidation during sleep in young and older adults. Data from the current grant by the co-PI shows that LIT improves sleep (measured via actigraphy and questionnaires), depression and agitation in late stages AD patients. The current grant is a logical extension of the co-PIs work: it will include MCI and mild AD patients and it will measure EEG and cognitive performance, none of which are included in the current grant activities. In addition to improving patients’ lives, LIT has the potential to reduce burden on caregivers. Thus, an exploratory goal is to also measure the impact of LIT on caregivers’ sleep, cognition, depression, and quality of life. We will demonstrate that a practical, effective, tailored, nonpharmacological LIT can be used to improve sleep, cognition, and quality of life in older adults with MCI and mild AD living at home or in independent or assisted living facilities, thereby possibly mitigating significant financial and social burdens. The proposed work is significant because it will be the first to investigate the relationship between long-term use of light therapy, a safe and easy to use intervention, and sleep and cognition in MCI and mild AD patients, as well as its impact on caretakers. Given evidence linking the sleep’s importance in the development of AD, the proposed studies can have a significant impact on the progression of MCI and mild AD, and caregivers’ quality of life.

项目摘要/摘要数据表明，在患有阿尔茨海默氏病（AD）的5.5百万年长美国人中，约有40％患有严重的睡眠 - 沃克和昼夜节律系统的功能障碍。在轻度认知障碍（MCI）的人中，这是一个“ AT 痴呆症的风险或潜在的前驱阶段，高达60％的患者可以证明睡眠疗法灾难。睡眠至关重要用于老年人健康的认知处理。该申请提案要研究长期的影响 MCI和轻度AD患者的睡眠生理和睡眠依赖性认知过程的照明治疗。我们假设长期（6个月）的照明干预技术（LIT）旨在促进昼夜节律将改善睡眠，从而改善认知。我们还假设点燃将改善抑郁症和生活质量（QOL）。单臂随机，安慰剂对照（非活动的比较照明干预），受试者间研究，我们将调查6个月暴露点燃的影响（干预后3个月的“纯粹随访期”）对以下方式的影响（1）睡眠的客观测量（脑电图，行摄影），（2）睡眠的主题测量（匹兹堡睡眠质量指数），（3）认知（工作和长期记忆），以及（4）抑郁和QOL（问卷）。我们的科学前提是睡眠纺锤体和纺锤体相对于SO的时机是相互作用的关键组成部分电生理事件，为年轻人的睡眠期间的记忆巩固提供了机械解释老年人。 Co-Pi当前赠款的数据表明，LIT可以改善睡眠（通过行动学和问卷），晚期抑郁和躁动AD患者。当前的赠款是副派的逻辑扩展工作：它将包括MCI和温和的AD患者，它将衡量脑电图和认知表现包括当前的赠款活动。除了改善患者的生活外，LIT还具有减少护理人员燃烧的潜力。那是一个探索目标是还可以衡量照明对看护人睡眠，认知，抑郁和生活质量的影响。我们将证明可以使用实用，有效，量身定制的非药理学点亮来改善睡眠，认知和生活质量有MCI和温和广告的老年人生活在家里或独立或辅助生活设施中，从而可能减轻大量财务和社会伯恩斯。拟议的工作很重要，因为它将是第一个调查长期使用光疗法的关系，一种安全易于使用的干预措施，睡眠和睡眠和 MCI和轻度AD患者的认知及其对看护人的影响。有证据与睡眠的进口联系起来在AD的开发中，拟议的研究可以对MCI和轻度AD的发展产生重大影响，和看护人的生活质量。