Filtered eyewear to prevent light-induced melatonin suppression while maintaining visual performance and alertness in night-shift working nurses

过滤眼镜可防止光引起的褪黑激素抑制，同时保持夜班护士的视觉表现和警觉性

• 批准号: 10639722
• 负责人: Mariana Gross Figueiro
• 金额: $ 67.37万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10639722
• 关键词: Filtered; eyewear; prevent; light; induced

Project Summary/Abstract. The suppression of melatonin production by nighttime retinal light exposure has been linked to health risks to nightshift workers. Blue-blocking filters can preserve nighttime melatonin levels, and monocular light exposures can radically reduce nighttime melatonin suppression to as little as 10% of that observed for conventional binocular exposures. Our premise is that positioning a blue-blocking orange filter over one eye will preserve binocular vision while reducing light-induced melatonin suppression relative to a completely unfiltered viewing condition. This solution should not impede the performance of visual tasks that might require binocular vision, nor should it cause user discomfort. We propose a laboratory experiment (Aim 1) to determine whether blue- blocking filters and monocular viewing, alone or in combination, are effective for maintaining melatonin at night without affecting visual performance and subjective sleepiness (KSS). Aim 2 will be conducted at the Simulation Teaching and Research Center (STAR) at the Icahn School of Medicine at Mount Sinai to determine whether altered viewing interventions could influence melatonin levels and simulated task performance requiring depth perception (e.g., catheter / intra venous insertion in dummy) in healthcare workers. For Aim 3, involving nightshift working workers operating in actual hospital environments at Mount Sinai Hospital and Memorial Hospital in South Bend, IN, we will determine whether eyewear aimed at maintaining melatonin at night would be effective, practical, and socially acceptable. Aim 1 will employ a crossover within-subjects design, exposing subjects to 6 experimental conditions (monocular/binocular x filtered/non-filtered, 2 controls) over the course of 6 independent sessions. Aim 2 will employ a within-subjects design exposing subjects to 4 experimental conditions (control, filtered binocular, filtered monocular, unfiltered monocular/dominant eye occluded) over the course of 4 nightshifts (separated by at least a week). Aim 3 will be employ a within-subjects design similar to Aim 2 over the course of 4 one-week sessions (at least 3 shifts per session) with salivary melatonin levels, sleepiness scores, and Likert scale responses, as the output measures. This proposal is significant from a practical perspective because the methods to be tested could serve as elegant, inexpensive, personalized, non-invasive optical interventions to protect the natural synthesis of melatonin in night-shift workers. We will be addressing Healthy Work Design and Well-being (cross-sector). As part of the Research to Practice (r2p) activity, we will address need to maintain melatonin at night among nightshift nurses with a novel, but inexpensive technology, and evaluate its efficacy in practice.

项目摘要/摘要。 通过夜间视网膜照明暴露对褪黑激素产生的抑制与健康风险有关 夜班工人。蓝块过滤器可以保留夜间褪黑激素水平，并且单眼曝光 从根本上可以将夜间褪黑激素抑制降低到常规观察 双眼暴露。我们的前提是，将蓝色块橙色过滤器放在一只眼睛上可以保存 相对于完全未经过滤的观察，双眼视觉减少了光诱导的褪黑激素抑制 健康）状况。该解决方案不应阻碍可能需要双眼视觉的视觉任务的执行， 也不应引起用户不适。我们提出了一个实验室实验（目标1），以确定蓝色是否是否 单独或组合阻止过滤器和单眼观察可有效地维持褪黑激素 不影响视觉表现和主观嗜睡（KSS）。 AIM 2将在模拟时进行 西奈山的伊坎医学院的教学与研究中心（Star）确定是否是否 观看干预措施的改变可能会影响褪黑激素水平和模拟任务性能需要深度 卫生保健工人的感知（例如，假人中的导管 /静脉内插入）。对于目标3，涉及 在西奈山医院和纪念馆的实际医院环境中经营的夜班工作人员 印第安纳州南本德的医院，我们将确定目的是在晚上维持褪黑激素 有效，实用且在社会上可以接受。 AIM 1将采用主题内部设计的跨界 在整个过程中，受到6个实验条件（单眼/双眼X过滤/未过滤，2个对照）的受试者 6个独立会议。 AIM 2将采用受试者的主题内设计，以4个实验性接触受试者 条件（对照，过滤的双眼，过滤单眼，未经过滤的单眼/主要眼睛被遮挡） 4个夜班的过程（至少一个星期分开）。 AIM 3将采用类似的受试者内部设计 在4周的4周（每次会议至少3个班次）的过程中，AIM 2具有唾液褪黑激素水平， 嗜睡得分和李克特量表响应作为输出度量。该提议从实用中很重要 观点是因为要测试的方法可以用作优雅，廉价，个性化，无创的 光学干预措施以保护夜班工人中褪黑激素的自​​然合成。我们将解决 健康的工作设计和福祉（跨部门）。作为练习（R2P）活动的研究的一部分，我们将 地址需要在夜班护士中维持褪黑激素，并采用一种小说但廉价的技术， 并在实践中评估其功效。