Bioinformatics

生物信息学

基本信息

批准号：
8896641
负责人：
KAREN E KNUDSEN
金额：
$ 12.31万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8896641
关键词：
Bioinformatics Bioinformatics Shared Resource Biomedical Research Biometry Cancer Center Cancer Patient Clinical Clinical Research Clinical Trials Collaborations Communities Community Hospitals Complement Computer software Computers Consultations Contracts Core Facility Data Data Analyses Databases Disasters Equipment Funding Generations Grant Health Insurance Portability and Accountability Act Individual Informatics Information Technology Instruction Malignant Neoplasms Mining Mission NCI Center for Cancer Research Operations Research Pathology Peer Review Privacy Publications Recovery Regulation Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Reservations Resource Informatics Resource Sharing Resources Security Services Specimen System Technology Tissue Banking Tissue Banks Translational Research United States National Institutes of Health Universities anticancer research biomedical informatics cancer genomics cohort common rule data management direct application human subject informatics shared resource interest interoperability member neoplasm registry operation programs repository software development tool tumor registry web site

项目摘要

PROJECT SUMMARY (See instructions): The Informatics Shared Resource (ISR) serves as a biomedical research informatics resource for KCC's basic, clinical, and translational investigators. This support includes infrastructure! provisioning, software development or acquisition, and consultative collaboration. ISR services are available directly to peer reviewed funded cancer investigators, or indirectly to other cancer center core facilities, thereby providing services to all program members. The ISR also provides informatics support for the clinical research activities of the Jefferson Kimmel Cancer Center Network of community hospitals. More specifically, the ISR supports cancer center research by developing and/or deploying: 1) Clinical trials applications to give clinical researchers the tools to manage clinical trials data, including mandated reporting. 2) Biospecimen repository applications to help tissue bank staff manage specimen accessioning and distribution, and provide investigators with an ordering mechanism and information characterizing specimens available for research. 3) Data warehousing and mining applications to provide cancer researchers with a research data mart that integrates clinical, biospecimen, cancer registry, clinical trials, and experimental data for cohort identification and hypothesis generation. 4) Infrastructure and applications for other KCC shared resources to facilitate access to their services. The ISR thus provides KCC investigators with ready access to integrated comprehensive information on clinical trials, cancer patients, and research specimens, as well as providing a single portal for requesting equipment and services from KCC shared resources. In all its activities, the ISR recognizes interoperability as crucial to the sharing of research data and resources to promote efficient cancer research, and utilizes standards articulated by the NCI and the biomedical informatics community. Software applications are hosted on servers with networked storage located at a commercial data center contracted by the University, providing professional data center security and disaster recovery services. The ISR employs best practices with regard to data privacy and security complying with the Common Rule, HIPAA, and state regulations.

项目摘要（参见说明）：信息学共享资源 (ISR) 为 KCC 的基础、临床和转化研究人员提供生物医学研究信息学资源。这种支持包括基础设施！供应、软件开发或采购以及咨询协作。 ISR 服务可直接提供给同行评审资助的癌症研究人员，或间接提供给其他癌症中心核心设施，从而为所有计划成员提供服务。 ISR 还为杰斐逊金梅尔癌症中心社区医院网络的临床研究活动提供信息学支持。更具体地说，ISR 通过开发和/或部署以下内容来支持癌症中心研究： 1) 临床试验应用程序为临床研究人员提供管理临床试验数据的工具，包括强制报告。 2) 生物样本存储库应用程序，帮助组织库工作人员管理样本加入和分发，并为研究人员提供订购机制和表征可用于研究的样本的信息。 3) 数据仓库和挖掘应用程序为癌症研究人员提供一个研究数据集市，该集市集成了临床、生物样本、癌症登记、临床试验和实验数据，用于队列识别和假设生成。 4) 其他 KCC 共享资源的基础设施和应用程序，以方便访问其服务。因此，ISR 为 KCC 研究人员提供了对临床试验、癌症患者和研究样本的综合综合信息的便捷访问，并提供了从 KCC 共享资源请求设备和服务的单一门户。在其所有活动中，ISR 认识到互操作性对于共享研究数据和资源以促进高效的癌症研究至关重要，并利用 NCI 和生物医学信息学界制定的标准。软件应用程序托管在大学签约的商业数据中心内具有网络存储的服务器上，提供专业的数据中心安全和灾难恢复服务。 ISR 采用数据隐私和安全方面的最佳实践，符合通用规则、HIPAA 和州法规。