Molecular Biology and Genetics Program

分子生物学和遗传学计划

基本信息

批准号：
9071324
负责人：
KAREN E KNUDSEN
金额：
$ 3.09万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9071324
关键词：
Biochemistry Biology Cancer Center Cancer Patient Cell Proliferation Cells Collaborations Diagnosis Faculty Gene Expression Regulation Gene Targeting Genes Genetic Programming Genetic Transcription Goals Grant Hematologic Neoplasms Immunity Influentials Institutes Journals Malignant Neoplasms Medical Research Molecular Molecular Biology Molecular Genetics Nature Normal Cell Oncogenes Paper Peer Review Peer Review Grants Postdoctoral Fellow Prevention therapy Process Publications Publishing Solid Neoplasm Testing Training Transcriptional Regulation Translating Translational Research Tumor Markers Universities base cancer diagnosis cancer prevention cell growth cost design gene discovery gene function graduate student improved interest meetings member mouse model neoplastic cell novel novel diagnostics novel therapeutic intervention personalized medicine prognostic programs targeted treatment tumor tumorigenesis

项目摘要

Program 2, the Molecular Biology and Genetics of Cancer Program (MBG), integrates fundamental studies in the control of gene transcription and regulation with the genetic and molecular mechanisms underlying the most common types of solid tumors and hematological malignancies. An integral part of the KCC since 1991, this program focuses on gene discovery and gene function analyses in order to exploit the translational potential of these studies for cancer diagnosis, assessment, prevention and therapy. The long-term goal of this program is to discover information useful in designing "personalized therapies" for cancer patients. The Molecular Biology and Genetics of Cancer Program brings together 22 faculty members from 10 academic departments (including the Lankenau Institute for Medical Research and the Department of Biochemistry and Molecular Biology of Drexel University) who are supported by NCI ($3.25 million total costs) and other peer-reviewed grants ($7.80 million total costs). Many members of this program have made important discoveries that have been translated into improved cancer diagnosis and assessment, and into novel therapeutic approaches. In the last five years, program members have continued to interact productively, publishing approximately 100 papers/year in some of the best known and more influential journals such as Nature, Mol.Cell, J.Clin.Invest., Immunity, PNAS. Of papers published since 2007, 21.0% have been the result of intra-programmatic collaborations and 31.3% the result of inter-programmatic collaborations. The program has 15-20 graduate students and more than 80 postdoctoral fellows. Their training and the interactions, both intra- and inter-programmatic, among all members are supported by monthly meetings that enhance the program's translational focus.

计划 2，癌症分子生物学和遗传学计划 (MBG)，整合了以下领域的基础研究：基因转录和调控的控制及其背后的遗传和分子机制最常见的实体瘤和血液恶性肿瘤类型。自 1991 年起成为 KCC 的组成部分，该计划侧重于基因发现和基因功能分析，以利用转化这些研究在癌症诊断、评估、预防和治疗方面的潜力。长期目标是该计划旨在发现有助于为癌症患者设计“个性化疗法”的信息。这癌症分子生物学和遗传学项目汇集了来自 10 个学术领域的 22 名教职人员部门（包括兰克瑙医学研究所和生物化学系德雷塞尔大学分子生物学）得到 NCI（总费用 325 万美元）和其他同行评审的支持赠款（总费用 780 万美元）。该计划的许多成员都有重要发现已转化为改进的癌症诊断和评估以及新的治疗方法接近。在过去五年中，计划成员继续进行富有成效的互动，出版每年在一些最著名和更有影响力的期刊上发表约 100 篇论文，例如 Nature、 Mol.Cell、J.Clin.Invest.、免疫、PNAS。自 2007 年以来发表的论文中，21.0% 是以下结果：项目内合作和 31.3% 是项目间合作的结果。该计划拥有研究生15-20名，博士后80余名。他们的训练和互动，都所有成员之间的计划内和计划间均得到每月会议的支持，以加强计划的翻译重点。