Core 1 - Biostatistics

核心 1 - 生物统计学

• 批准号: 10628256
• 负责人: BETH A. REBOUSSIN
• 金额: $ 30.16万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628256
• 关键词: Adolescent; Baptist Church; Bioinformatics; Biometry; Biostatistics Core; Biostatistics Shared Resource; Cardiovascular Diseases; Cataloging; Cluster randomized trial; Collaborations; Collection; Comprehensive Cancer Center; Consultations; Cross-Sectional Studies; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Element; Data Management Resources; Data Science; Data Set; Data Storage and Retrieval; Database Management Systems; Databases; Documentation; Ensure; Formulation; Funding; Health Sciences; Health behavior; Image; Individual; Infrastructure; Intervention; Laboratory Procedures; Life; Longitudinal cohort study; Malignant Neoplasms; Measurement; Metadata; Methodology; Mission; Monitor; Online Systems; Outcome; Participant; Persons; Population; Probability Samples; Procedures; Public Health; Quality Control; Randomized; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Risk Assessment; Sample Size; Sampling; Schools; Secure; Services; Statistical Data Interpretation; Stratification; Surveys; Technical Expertise; Techniques; United States National Institutes of Health; Weight; arm; benefit sharing; biomedical informatics; data cleaning; data integration; data management; data sharing; database design; design; experience; forest; health communication; medical schools; member; multidisciplinary; programs; quality assurance; recruit; relational database; skills; statistics; synergism; vaping

ABSTRACT – CORE 001: Biostatistics Core The Biostatistics Core will provide the shared biostatistical services and data coordination necessary for this Program Project. It will provide comprehensive support of the web-based surveys, lab-based studies, and the randomized cluster health communication trial from study design, sampling, data collection, quality control, and database management to biostatistical analysis and dissemination. Use of a centralized core will support the overall conceptual framework for the Program Project, resulting in consistency in measurement and analysis across studies and other cores. The Biostatistics Core draws upon the skills and expertise housed within the Department of Biostatistics and Data Science in the Division of Public Health Sciences at Wake Forest School of Medicine, a department with extensive experience serving as a data coordinating center for numerous multi- center NIH-funded studies, and from the Biostatistics Shared Resource of the Wake Forest Baptist Comprehensive Cancer Center. The mission of the Biostatistics Core is to provide a complete and well- integrated infrastructure for the collection and analysis of study data, ensuring appropriate inferences are made when disseminating results. The Aims of the core are to: 1) Provide statistical expertise on study design and sample selection; 2) Perform data management activities including database creation, quality control, integration, and sharing; and 3) Conduct statistical analyses and facilitate proper statistical inference from appropriately prepared datasets. This centralized core will provide the technical skills necessary for the collection of research data via web-based surveys and in-person laboratory procedures and will provide a skilled team for the statistical analysis of these data sets. Through a coordinated collaboration between this Core and each project, we will ensure an efficient means of collecting and analyzing data for all research projects described in this proposal. The primary objectives of the Biostatistics Core are the provision of needed biostatistical services, including design, sampling, data management, analysis, and dissemination.

摘要 – CORE 001：生物统计学核心 生物统计核心将提供为此所需的共享生物统计服务和数据协调 它将提供基于网络的调查、基于实验室的研究和 随机整群健康传播试验从研究设计、抽样、数据收集、质量控制和 使用集中核心将支持从数据库管理到生物统计分析和传播。 该计划项目的总体概念框架，导致测量和分析的一致性 生物统计学核心利用了各个研究和其他核心领域的技能和专业知识。 维克森林学院公共卫生科学系生物统计和数据科学系 医学部，一个拥有丰富经验的部门，作为众多多方的数据协调中心 NIH 资助的中心研究，来自维克森林浸信会生物统计共享资源 综合癌症中心的使命是提供一个完整且良好的 用于收集和分析研究数据的综合基础设施，确保做出适当的推论 传播结果时，核心的目标是： 1) 提供研究设计和统计方面的专业知识。 2) 执行数据管理活动，包括数据库创建、质量控制、 整合和共享；以及 3) 进行统计分析并促进适当的统计推断 该集中核心将提供适当准备的数据集所需的技术技能。 通过基于网络的调查和现场实验室程序收集研究数据，并将提供 通过这之间的协调合作，熟练的团队对这些数据集进行统计分析。 核心和每个项目，我们将确保以有效的方式收集和分析所有研究的数据 本提案中描述的项目的主要目标是提供所需的信息。 生物统计服务，包括设计、抽样、数据管理、分析和传播。