Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample

在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康

• 批准号: 10668466
• 负责人: Mariana Gross Figueiro
• 金额: $ 11.98万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-20 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10668466
• 关键词: Activity Cycles; Adult; Adverse effects; Behavior; Behavioral; Biological Markers; Blood Pressure; Body Composition; Cardiometabolic Disease; Cardiovascular Diseases; Characteristics; Circadian Rhythms; Circadian desynchrony; Clinical; Darkness; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Disparity; Disparity population; Elements; Environmental Exposure; Exercise; Exposure to; General Population; Health; Hour; Human; Impairment; Investigation; Light; Link; Lipids; Low Income Population; Measurement; Measures; Metabolic Diseases; Methods; National Health and Nutrition Examination Survey; Obesity; Occupational; Outcome; Participant; Patient Self-Report; Pattern; Periodicity; Phase; Physiological; Pilot Projects; Play; Population; Process; Public Health; Publishing; Reporting; Rest; Risk Factors; Role; Sampling; Schedule; Signal Transduction; Sleep; Stimulus; Subgroup; System; Testing; Therapeutic Intervention; Underrepresented Populations; Variant; Wrist; actigraphy; cardiometabolic risk; cardiometabolism; circadian; design; disease disparity; disorder risk; ethnic minority; glycemic control; health disparity; improved; insight; light entrainment; modifiable risk; molecular clock; neighborhood disadvantage; novel; older men; preventive intervention; racial minority; shift work; sleep health; socioeconomics; study characteristics; suprachiasmatic nucleus; therapy development

PROJECT SUMMARY Circadian rhythms, generated by endogenous molecular clocks and entrained by the light-dark cycle, play a central role in orchestrating many physiological and behavioral processes related to cardiometabolic health. A growing body of evidence has linked light exposure at different times of the day and cardiometabolic outcomes, suggesting that characteristics of 24-hour light-dark cycle may be unique predictors of disease risk. However, there is a lack of investigation focusing on comprehensively assessing 24-hour light exposure, and in particular, its alignment with diurnal behavioral, to understand its health implications in human populations. A well- established hallmark of a healthy circadian timing system is the synchronization and proper alignment of multiple elements, such as between the environmental stimuli (e.g., light-dark cycle) and diurnal behaviors (e.g., activity- rest cycle). Our pilot study in older men applied phasor analysis to assess the alighnment between actigraphy- measured 24-hour light-dark and activity-rest cycles, and we found that impaired alignment between the two was associated with diabetes. These findings suggest that poor synchronization between the timing of light exposure and activity patterns may be a unique predictor of cardiometabolic risk, a novel hypothesis that needs to be tested in broader populations. We propose to test this hypothesis by conducting secondary data analysis in the National Health and Nutrition Examination Survey (NHANES, 2011-2014), which has detailed data on 24-hour light and activity patterns and rich information on cardiometabolic health. Moreover, the diverse and nationally representative sample will allow us to determine how 24-hour patterns of light exposure, its interrelationship with activity-rest cycles, and their associations with cardiometabolic outcomes may vary among subgroups with different demographic, socioeconomic, and occupational characteristics. Aim 1 Study characteristics of 24- hour light exposure and its alignment with rest and activity patterns in relation to cardiometabolic health in adult participants in NHANES. In this aim we will apply parametric and nonparametric methods to characterize multiple aspects of light-dark cycles and phasor analysis to characterize the alignment between light-dark and activity-rest cycles to study their associations with cardiometabolic outcomes. Aim 2 Study light exposure, alignment with rest and activity, and their associations with cardiometabolic health in adult populations with different demographic, socioeconomic and occupational attributes. In this aim we will examine multiple population attributes as determinants of 24-hour light-dark cycles and its alignment with activity- rest cycles, and as moderators of the association between light exposure and cardiometabolic health. Light exposure is a potentially modifiable risk factor for cardiometabolic diseases, and our study will help better understand the contribution of light exposure to cardiometabolic health and disease disparities, and provide evidence for developing preventive and therapeutic interventions aimed at manipulating light exposure and activity-rest patterns to improve circadian function and cardiometabolic health.

项目摘要 昼夜节律，由内源分子时钟产生，并由光黑暗周期夹带 在策划与心脏代谢健康有关的许多生理和行为过程中的中心作用。一个 越来越多的证据已经将一天中不同时间的光暴露与心脏代谢结果联系在一起， 表明24小时浅黑暗周期的特征可能是疾病风险的独特预测指标。然而， 缺乏调查的重点是全面评估24小时的光线暴露，尤其是 它与昼夜行为的一致性，以了解其在人类人群中的健康含义。一个好 健康的昼夜节律定时系统建立的标志是多个的同步和正确对齐 元素，例如环境刺激（例如，黑暗周期）和昼夜行为（例如，活动 - 休息周期）。我们对老年男性的试点研究应用了相位分析，以评估行动语义 - 测量了24小时的浅黑暗和活动式循环，我们发现两者之间的比对受损是 与糖尿病有关。这些发现表明，光线的时机之间的同步不佳 活动模式可能是心脏代谢风险的独特预测指标，这是一个新的假设，需要为 在更广泛的人群中进行了测试。我们建议通过在 国家卫生和营养检查调查（NHANES，2011-2014），该调查有24小时的详细数据 光与活动模式以及有关心脏代谢健康的丰富信息。而且，多元化和全国各地 代表性样本将使我们能够确定24小时的光曝光模式如何，与之相互关系 活动式循环及其与心脏代谢结果的关联可能在亚组中有所不同 不同的人口，社会经济和职业特征。目标1 24-的研究特征 小时光线暴露及其与心脏代谢健康有关的休息和活动模式的对齐 在NHANES的成年参与者中。在此目标中，我们将应用参数和非参数方法 表征浅黑色周期和相拟合分析的多个方面，以表征 浅黑暗和活性宿主周期研究其与心脏代谢结果的关联。 AIM 2学习灯 暴露，与休息和活动保持一致，以及它们与成人心脏代谢健康的关联 人口，社会经济和职业属性不同的人群。在这个目标中，我们将 将多个种群属性视为24小时浅黑暗循环的决定因素及其与活性的比对 休息周期，作为光暴露与心脏代谢健康之间关联的主持人。光 暴露是心脏代谢疾病的潜在可修改的危险因素，我们的研究将有助于更好 了解暴露于心脏代谢健康和疾病差异的贡献，并提供 制定旨在操纵光暴露和的预防性和治疗干预措施的证据 活性及以改善昼夜节律功能和心脏代谢健康的模式。