The impact of social evaluation on perception of facial affect in adults with social anxiety

社会评价对社交焦虑成人面部情感感知的影响

• 批准号: 10613913
• 负责人: Dana Elizabeth Diaz
• 金额: $ 1.19万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-25 至 2023-06-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10613913
• 关键词: Adult; Affect; Amygdaloid structure; Anger; Anterior; Anxiety; Anxiety Disorders; Arbitration; Attention; Auditory; Behavioral; Brain region; Color; Complex; Cues; Data; Detection; Dorsal; Emotional; Emotions; Etiology; Evaluation; Event; Experimental Designs; Face; Face Processing; Facial Expression; Fright; Functional Magnetic Resonance Imaging; Fusiform gyrus; Future; Happiness; Impairment; Individual; Intervention; Knowledge; Life; Measures; Mental Health; Modeling; Multivariate Analysis; Participant; Pattern; Perception; Persons; Population; Prefrontal Cortex; Process; Psychophysiology; Research; Sampling; Sensory; Shapes; Signal Transduction; Social Anxiety Disorder; Social Interaction; Social Perception; Source; Stimulus; Structure; Symptoms; Techniques; Testing; United States; Visual; Work; Youth; analytical method; anxiety symptoms; anxious individuals; area striata; behavior measurement; blood oxygenation level dependent response; cingulate cortex; ethnic diversity; insight; interest; negative affect; neural; neural circuit; neuroimaging; neuromechanism; response; social; social anxiety; social bias; social influence; social situation; social stressor; trait; vigilance; young adult

Project Summary/Abstract Social anxiety disorders are one of the most common and widely impairing mental health issues among adults in the United States. Social anxiety is characterized by anxiety from anticipation of aversive future social events. Elevations in such anticipatory anxiety may bias perception of threat stimuli through enhanced connections between the amygdala and visual sensory regions. Upon viewing threatening face stimuli, people with social anxiety display increased activity in perceptual and face-processing regions and increased connectivity between these regions and the amygdala, suggesting a possible etiological account for social anxiety disorders. However, current research examining the underlying neural origins of biased perception and its contributions to anxiety disorders suffers from important limitations. First, much of this work has focused on how attentional mechanisms increase vigilance to threat stimuli, and less is known about sensory representations of threat in visual circuitry. Second, the degree to which extant models of perceptual biases in anxiety are generalizable beyond white, middle SES adults is not known. Finally, most fMRI studies that investigate biases in emotion perception in social anxiety disorder have employed univariate analyses which do not characterize how information is represented in neural activity patterns, limiting inferences about how social anxiety might influence sensory representations of threat. In two aims, the proposed study will address these limitations by applying univariate, multivariate, and functional connectivity analyses, in an ethnically diverse sample of young adults with and without social anxiety. Aim 1 will test whether trait social anxiety influences neural and behavioral sensitivity to threat upon viewing ambiguous faces blended between threatening (fear/anger) and safe (happy) expressions. Aim 2 will test whether experimentally inducing anticipatory anxiety via a social threat influences neural and behavioral threat sensitivity. Signal detection theoretic metrics will measure behavioral threat sensitivity, or the degree of threat affect required for a face to be judged as fearful or angry. Univariate and multivariate measures of neural activity will characterize neural threat sensitivity in perceptual (V1, fusiform gyrus) and emotional (amygdala, anterior insular cortex, dorsal anterior cingulate cortex, dorsomedial prefrontal cortex, ventrolateral prefrontal cortex) brain regions. Functional connectivity analyses will probe the cortical networks underlying anticipatory anxiety in social anxiety. By inducing anticipatory anxiety, I can test whether social threat increases connectivity between the amygdala and perceptual regions and concomitantly alters multivoxel sensory representations of ambiguous facial affect, which has not yet been done. Together, these aims focus on an understudied but central feature of social anxiety disorders, builds on my knowledge of new multivariate analytic techniques and promises to provide new information about the neural mechanisms underlying social anxiety.

项目摘要/摘要 社交焦虑症是成年人中最常见和最广泛损害的心理健康问题之一 在美国。社交焦虑的特征是焦虑于期待厌恶的未来社会 事件。这种预期焦虑中的高程可能会通过增强来偏向威胁刺激的感知 杏仁核与视觉感觉区域之间的连接。在观看威胁性的面部刺激后，人们 随着社交焦虑显示在感知和面部处理区域的活动增加，并增加了 这些地区与杏仁核之间 焦虑症。但是，目前研究了偏见的感知和 它对焦虑症的贡献受到了重要的局限性。首先，这项工作的大部分都集中在 注意机制如何增加对威胁刺激的警惕性，而对感官的了解却更少 视觉电路中威胁的表示。其次，现有的知觉偏见模型的程度 焦虑是可以推广的，超出白人，中间SES成人尚不清楚。最后，大多数fMRI研究 调查社交焦虑症中情感感知的偏见已采用单变量分析，这些分析 不要表征信息在神经活动模式中的表示，从而限制了有关如何的推论 社交焦虑可能会影响威胁的感官表示。在两个目标中，拟议的研究将解决 这些局限性通过在种族上应用单变量，多变量和功能连接分析。 有和没有社交焦虑的年轻人的不同样本。 AIM 1将测试特质社交焦虑是否 在观察歧义面孔时影响神经和行为敏感性 威胁（恐惧/愤怒）和安全（快乐）表达。 AIM 2将测试是否在实验中诱导 通过社会威胁通过社会威胁的预期焦虑会影响神经和行为威胁敏感性。信号检测 理论指标将衡量行为威胁敏感性，或面对面所需的威胁影响程度 被判断为恐惧或生气。神经活动的单变量和多元措施将表征神经 感知（V1，梭形回）和情感（杏仁核，前岛皮层，背侧）的威胁敏感性 前扣带回皮层，背额前额叶皮层，腹外侧前额叶皮层）脑区域。 功能连通性分析将探测社会预期焦虑的基础网络 焦虑。通过引起预期焦虑，我可以测试社会威胁是否会增加 杏仁核和感知区域以及随之而来的改变模棱两可的多氧化感觉表示 面部影响，尚未完成。这些目的共同集中于研究的但中心的特征 社交焦虑症，建立在我对新的多元分析技术的了解的基础上，并有望 提供有关社交焦虑的神经机制的新信息。