The impact of social evaluation on perception of facial affect in adults with social anxiety

社会评价对社交焦虑成人面部情感感知的影响

基本信息

批准号：
10464818
负责人：
Dana Elizabeth Diaz
金额：
$ 4.1万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-25 至 2023-10-24
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10464818
关键词：
Address Adult Affect Amygdaloid structure Anger Anterior Anxiety Anxiety Disorders Arbitration Attention Auditory Behavioral Brain region Color Complex Cues Data Detection Dorsal Emotional Emotions Etiology Evaluation Event Experimental Designs Face Face Processing Facial Expression Fright Functional Magnetic Resonance Imaging Fusiform gyrus Future Generalized Anxiety Disorder Impairment Individual Intervention Knowledge Lead Life Measures Mental Health Modeling Multivariate Analysis Participant Pattern Perception Persons Population Prefrontal Cortex Process Psychophysiology Research Sampling Sensory Shapes Signal Transduction Social Anxiety Disorder Social Interaction Social Perception Source Stimulus Structure Symptoms Techniques Testing United States Visual Work Youth analytical method anxiety symptoms anxious individuals area striata behavior measurement blood oxygenation level dependent response cingulate cortex ethnic diversity generalized anxiety imaging study insight interest negative affect neural circuit neuroimaging neuromechanism relating to nervous system response social social anxiety social bias social influence social stressor trait vigilance young adult

项目摘要

Project Summary/Abstract Social anxiety disorders are one of the most common and widely impairing mental health issues among adults in the United States. Social anxiety is characterized by anxiety from anticipation of aversive future social events. Elevations in such anticipatory anxiety may bias perception of threat stimuli through enhanced connections between the amygdala and visual sensory regions. Upon viewing threatening face stimuli, people with social anxiety display increased activity in perceptual and face-processing regions and increased connectivity between these regions and the amygdala, suggesting a possible etiological account for social anxiety disorders. However, current research examining the underlying neural origins of biased perception and its contributions to anxiety disorders suffers from important limitations. First, much of this work has focused on how attentional mechanisms increase vigilance to threat stimuli, and less is known about sensory representations of threat in visual circuitry. Second, the degree to which extant models of perceptual biases in anxiety are generalizable beyond white, middle SES adults is not known. Finally, most fMRI studies that investigate biases in emotion perception in social anxiety disorder have employed univariate analyses which do not characterize how information is represented in neural activity patterns, limiting inferences about how social anxiety might influence sensory representations of threat. In two aims, the proposed study will address these limitations by applying univariate, multivariate, and functional connectivity analyses, in an ethnically diverse sample of young adults with and without social anxiety. Aim 1 will test whether trait social anxiety influences neural and behavioral sensitivity to threat upon viewing ambiguous faces blended between threatening (fear/anger) and safe (happy) expressions. Aim 2 will test whether experimentally inducing anticipatory anxiety via a social threat influences neural and behavioral threat sensitivity. Signal detection theoretic metrics will measure behavioral threat sensitivity, or the degree of threat affect required for a face to be judged as fearful or angry. Univariate and multivariate measures of neural activity will characterize neural threat sensitivity in perceptual (V1, fusiform gyrus) and emotional (amygdala, anterior insular cortex, dorsal anterior cingulate cortex, dorsomedial prefrontal cortex, ventrolateral prefrontal cortex) brain regions. Functional connectivity analyses will probe the cortical networks underlying anticipatory anxiety in social anxiety. By inducing anticipatory anxiety, I can test whether social threat increases connectivity between the amygdala and perceptual regions and concomitantly alters multivoxel sensory representations of ambiguous facial affect, which has not yet been done. Together, these aims focus on an understudied but central feature of social anxiety disorders, builds on my knowledge of new multivariate analytic techniques and promises to provide new information about the neural mechanisms underlying social anxiety.

项目概要/摘要社交焦虑症是成年人中最常见且广泛损害心理健康的问题之一在美国。社交焦虑的特征是由于对未来社交活动的预期而感到焦虑。事件。这种预期焦虑的升高可能会通过增强对威胁刺激的感知而产生偏差。杏仁核和视觉感觉区域之间的联系。当人们看到威胁性的面部刺激时，患有社交焦虑的人感知和面部处理区域的活动增加，并且这些区域和杏仁核之间的连通性，表明社会可能的病因学解释焦虑症。然而，目前的研究正在研究偏见感知和偏见的潜在神经起源。它对焦虑症的贡献受到重要限制。首先，这项工作的大部分重点是注意力机制如何提高对威胁刺激的警惕性，而对感官知之甚少视觉电路中威胁的表征。其次，现有的感知偏差模型的程度焦虑症是否普遍存在于白人之外，但中年社会经济地位成年人的情况尚不清楚。最后，大多数功能磁共振成像研究表明研究社交焦虑症情绪感知的偏差采用了单变量分析，没有描述信息如何在神经活动模式中表示，限制了关于如何表示的推论社交焦虑可能会影响对威胁的感官表征。拟议的研究将解决两个目标通过在种族方面应用单变量、多变量和功能连接分析来克服这些局限性有或没有社交焦虑的年轻人的不同样本。目标 1 将测试是否存在社交焦虑特质在观看混合在一起的模糊面孔时，会影响神经和行为对威胁的敏感度威胁（恐惧/愤怒）和安全（快乐）的表达。目标 2 将测试是否通过实验诱导通过社会威胁产生的预期焦虑会影响神经和行为威胁敏感性。信号检测理论指标将衡量行为威胁敏感性，或者面对面交流所需的威胁影响程度。被判断为恐惧或愤怒。神经活动的单变量和多变量测量将表征神经感知（V1、梭状回）和情感（杏仁核、前岛叶皮质、背侧皮质）的威胁敏感性前扣带皮层、背内侧前额叶皮层、腹外侧前额叶皮层）大脑区域。功能连接分析将探讨社交中预期焦虑背后的皮质网络焦虑。通过诱发预期焦虑，我可以测试社会威胁是否会增加人们之间的联系杏仁核和知觉区域，并同时改变模糊的多体素感觉表征面部影响，尚未完成。总之，这些目标集中在一个未被充分研究但核心的特征上社交焦虑障碍，建立在我对新的多元分析技术的了解之上，并承诺提供有关社交焦虑背后的神经机制的新信息。