A Pilot Investigation of Network-Informed Personalized Treatment for Eating Disorders versus Enhanced Cognitive Behavioral Therapy and Dynamic Mechanisms of Change

饮食失调的网络信息个性化治疗与增强认知行为疗法和动态变化机制的试点研究

• 批准号: 10612256
• 负责人: Cheri Alicia Levinson
• 金额: $ 4.56万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10612256
• 关键词: Address; Affective; Anorexia Nervosa; Award; Binge eating disorder; Bulimia; Code; Cognitive; Cognitive Therapy; Data; Doctor of Philosophy; Eating Disorders; Evidence based treatment; Gold; Heterogeneity; Individual; Investigation; K-Series Research Career Programs; Mental disorders; Mentorship; Methods; Minority; Outcome; Participant; Research Personnel; Series; Shame; Shapes; Standardization; Symptoms; Testing; Treatment outcome; United States National Institutes of Health; Variant; Weight; base; career development; cognitive enhancement; mortality; personalized approach; personalized medicine; response; standard care; success

PROJECT SUMMARY/ABSTRACT Despite eating disorders (EDs) carrying one of the highest mortality rates among all psychiatric disorders, there is no evidence-based treatment for anorexia nervosa and only 50% of individuals respond to the gold standard treatment for bulimia nervosa and binge eating disorder (cognitive- behavioral therapy enhanced: CBT-E). These low response rates are likely partially due to the large variations in symptom presentations. One major factor contributing to the high rates of heterogeneity across EDs is the wide variety of cognitive-affective factors, which maintain active illness states. CBT-E is based on the idea that overvaluation of weight and shape is the primary cognitive-affective mechanism responsible for maintaining EDs ‘on average’ (i.e., for most individuals) and is delivered in a standardized format. However, there is a well-documented relationship between “non-traditional” cognitive-affective mechanisms, such as perfectionism, worry, and shame, and EDS. Therefore, a method is needed that can provide a more personalized approach to ED treatment by addressing the high heterogeneity and specifically targeting non-traditional cognitive-affective mechanisms. The specific aims of the proposed project are to: (1) develop a coding system to identify the traditional and non-traditional cognitive-affective targets that are addressed in both a personalized and standardized (CBT-E) treatment, (2) use personalized networks to examine if coded treatment targets correspond with data-identified and manualized (i.e., CBT-E) treatment targets, (3) identify coded profiles of participants with non-traditional cognitive-affective profiles versus ED-traditional cognitive- affective profiles, and (4) test if participants with non-traditional cognitive-affective profiles versus ED-traditional cognitive-affective profiles from idiographic networks differ in treatment outcomes via condition. This project will be an important initial step towards identifying the relations between eating disorders, cognitive-affective factors, and outcomes in eating disorders to use in personalized treatments. Importantly, the career development and mentorship plan outlined in this diversity supplement application will promote Ms. Ortiz’s success as a minority researcher and contribute to the initiative of building a scientific workforce.

项目摘要/摘要 尽管饮食失调（EDS）在所有精神病学中均具有最高死亡率之一 疾病，没有针对厌食症的循证治疗，只有50％的个体 应对贪食症神经和暴饮暴食障碍的黄金标准治疗（认知 - 行为疗法增强：CBT-E）。这些较低的响应率可能部分是由于 症状表现差异很大。一个主要因素，导致高率 EDS之间的异质性是多种认知影响因素，它们保持活跃 疾病状态。 CBT-E是基于重量和形状高估的想法 负责“平均”维护EDS的认知影响机制（即大多数 个人），并以标准化格式交付。但是，有一个有据可查的 “非传统”认知影响机制（例如完美主义）之间的关系 忧虑，羞耻和eds。因此，需要一种可以提供更多的方法 通过解决高异质性，特别是针对急诊治疗的个性化方法 靶向非传统认知影响机制。提议的具体目的 项目是：（1）开发一个编码系统来识别传统和非传统的编码系统 在个性化和标准化（CBT-E）中解决的认知影响目标 治疗，（2）使用个性化网络检查编码治疗目标是否与 数据识别和手动（即CBT-E）治疗目标，（3）确定编码的轮廓 具有非传统认知影响概况与ED传统认知的参与者 情感概况和（4）测试是否具有非传统认知影响概况的参与者 与ed-传统的认知影响概况相比，来自遗传网络的治疗网络不同 结局通过条件。该项目将是迈向确定的重要第一步 饮食失调，认知影响因素和饮食失调结果之间的关系 用于个性化治疗。重要的是，职业发展和心态计划 在这种多样性补充申请中概述将促进Ortiz女士作为少数派的成功 研究人员并为建立科学劳动力的倡议做出了贡献。