Improving Symptoms in Older Breast Cancer Survivors

改善老年乳腺癌幸存者的症状

• 批准号: 6917380
• 负责人: SUSAN M. HEIDRICH
• 金额: $ 36.14万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6917380
• 关键词: behavioral /social science research tag; belief; breast neoplasms; clinical research; clinical trials; female; human old age (65+); human subject; human therapy evaluation; injury /disease stressor; interview; long term survivor; longitudinal human study; neoplasm /cancer therapy; patient oriented research; psychological aspect of cancer; psychological stressor; quality of life; questionnaires; sign /symptom; stress management; women' s health

DESCRIPTION (provided by applicant): We propose a randomized clinical trial to test the efficacy and durability of an Individualized Representational Intervention (IRIS) to reduce symptom distress and improve quality of life in older breast cancer (BC) survivors. IRIS is conceptually grounded in Donovan and Ward's Representational Approach to Patient Education (Donovan & Ward, 2001; Leventhal, Meyer, & Nerenz, 1980) and extensive preliminary research by the investigators in which beliefs about symptoms and symptom management were identified and an intervention to address these beliefs and improve symptom management was developed. Although 50% of breast cancers are in women over 65, their problems and needs have not been identified or addressed. Older breast cancer survivors face unique challenges because they experience symptoms of their disease and its treatment concurrent with symptoms of age related chronic illnesses, and they may hold beliefs that may function as barriers to effective symptom management. From this perspective, age is the salient context influencing women's experience of breast cancer as well as the dimensions that comprise quality of life. A sample of 207 women, aged 65 and over, and at least three months post-treatment for non-metastatic breast cancer will be randomly assigned to IRIS or Wait-List Control. IRIS is an individualized psychoeducational program delivered by an advanced practice nurse in a face-to-face interview with four telephone reinforcements. Data collection will occur at baseline and two, four, six, eight, and 16 weeks post-intervention using standardized instruments. The specific hypotheses are that IRIS will be superior to wait-list control with respect to symptom distress and quality of life from baseline to post-test and from baseline to follow-up and the effect of IRIS will be mediated by symptom management beliefs and strategies.

描述（由申请人提供）：我们提议进行一项随机临床试验，以测试个体化代表性干预（IRIS）的有效性和持久性，以减少老年乳腺癌（BC）幸存者的症状困扰并提高生活质量。 IRIS 在概念上基于 Donovan 和 Ward 的患者教育代表性方法（Donovan & Ward，2001；Leventhal、Meyer 和 Nerenz，1980）以及研究人员进行的广泛的初步研究，其中确定了对症状和症状管理的信念，并采取干预措施解决这些信念并改善症状管理已被制定。尽管 50% 的乳腺癌发生在 65 岁以上的女性身上，但她们的问题和需求尚未得到识别或解决。老年乳腺癌幸存者面临着独特的挑战，因为他们的疾病症状及其治疗与年龄相关的慢性疾病的症状同时存在，并且他们可能持有可能成为有效症状管理障碍的信念。从这个角度来看，年龄是影响女性乳腺癌经历以及生活质量的重要因素。 207 名年龄在 65 岁及以上且接受非转移性乳腺癌治疗至少三个月的女性样本将被随机分配到 IRIS 或等待名单控制组。 IRIS 是一项个性化心理教育计划，由高级执业护士通过四次电话增援进行面对面访谈。数据收集将在基线以及干预后两周、四周、六周、八周和 16 周时使用标准化仪器进行。具体假设是，从基线到测试后以及从基线到随访的症状困扰和生活质量方面，IRIS 将优于等待名单控制，并且 IRIS 的效果将通过症状管理信念和策略来调节。