Integrative analysis of human placental epi/genome in relation to fetal growth

人类胎盘表观/基因组与胎儿生长相关的综合分析

• 批准号: 10611359
• 负责人: Corina Lesseur Perez
• 金额: $ 24.4万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611359
• 关键词: Accounting; Address; Adult; Affect; Big Data; Bioinformatics; Biological; Biological Markers; Birth; Birth Weight; Blood specimen; Catalogs; Cell Separation; Cells; Child Health; Cohort Studies; Complex; Computational Biology; DNA; DNA Methylation; Data; Development; Disease; Elderly; Environment; Epidemiologist; Epidemiology; Face; Fetal Growth; Fetal health; Future; Gene Expression; Genome; Genomics; Genotype; Goals; Health; Heterogeneity; Human; Individual; Individual Differences; Inherited; Knowledge; Lasers; Life; Link; Longevity; Malignant Neoplasms; Maps; Maternal Health; Mentors; Mesenchymal; Methylation; Molecular; Molecular Epidemiology; Outcome; Pathology; Phase; Phenotype; Placenta; Placental Biology; Population Study; Proxy; Research; Research Personnel; Resources; Rhode Island; Sampling; Single Nucleotide Polymorphism; Syncytiotrophoblast; Tissue Sample; Tissues; Training; Work; cell type; cohort; cytotrophoblast; disorder prevention; disorder risk; early life exposure; empowerment; epidemiologic data; epidemiology study; experience; fetal; fetal programming; genome wide association study; genome-wide; genomic data; genomic locus; genomic profiles; improved; in utero; insight; interest; intrauterine environment; methylome; molecular subtypes; multiple omics; next generation; offspring; population based; risk prediction; trait; transcriptome; trophoblast

The goal of this proposal is to integrate multi-scale epi/genomic placental molecular features and relate this to fetal growth to provide mechanism insight into the contribution of the placenta to the Developmental Origins of Health and Disease (DOHaD). I am a molecular epidemiologist with a primary research interest in understanding inter-individual differences in disease risk and how early-life exposures can influence these differences. In the K99 phase, I trained in integrative genomics and bioinformatics, early-life epidemiology, and placental biology and pathology with the help of my mentors and advisors Drs. Ke Hao, Jia Chen, Carmen Marsit and Dr. Harvey Kliman. The aims of this research are: 1) to construct an integrative epi/genomic catalogue of term placentas; 2) to characterize cell-type specific DNA methylome and transcriptome to construct a cell-type reference panel for human term placenta and 3) to evaluate the influence of placental molecular features on birth weight. In this proposal, I leverage existent epi/genomic and epidemiological data from the Rhode Island Birth Cohort Study and placental cell-type specific epi/genomics profiles with the overarching goal of mapping placental molecular features involved in birth weight and DOHaD. The knowledge gained through this research has the potential to inform more broadly on the influence of the intrauterine environment on health throughout the lifespan and develop placental biomarkers to inform disease prevention.

该提案的目的是整合多尺度的Epi/Genomic胎盘分子特征并将其联系起来 胎儿生长以提供对胎盘对发育的贡献的洞察力 健康与疾病的起源（DOHAD）。我是一名具有主要研究兴趣的分子流行病学家 了解疾病风险的个体间差异以及早期暴露如何影响 这些差异。在K99阶段，我接受了综合基因组学和生物信息学的培训 在我的导师和顾问Drs的帮助下，流行病学以及胎盘生物学和病理学。 Ke Hao， Jia Chen，Carmen Marsit和Harvey Kliman博士。这项研究的目的是：1）构建 胎盘的综合性EPI/基因组目录； 2）表征细胞型特异性DNA甲基 和转录组，以构建人术语胎盘的细胞类型参考面板，3）评估 胎盘分子特征对出生体重的影响。在此提案中，我利用存在的EPI/基因组 以及罗德岛出生队列研究和胎盘细胞类型的流行病学数据 Epi/Genomics剖面具有映射胎盘分子特征的总体目标 体重和多哈。通过这项研究获得的知识有可能更广泛地告知 关于宫内环境对整个生命周期健康的影响并发展胎盘 生物标志物为预防疾病提供信息。