Heart Development and Disease: From Genes to Cures

心脏发育和疾病：从基因到治疗

基本信息

批准号：
10608624
负责人：
TERRY L. SHEPPARD
金额：
$ 1.62万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10608624
关键词：
Acceleration Address Adult Animal Disease Models Animal Model Biology Biophysics Cardiac Cardiac Myocytes Cardiovascular Diseases Cardiovascular system Cell Therapy Cell model Cells Child Clinical Trials Collaborations Development Developmental Biology Disadvantaged Disease Disease Progression Disease model Educational workshop Event Fertilization Functional disorder Genes Genetic Goals Health Expenditures Heart Heart Diseases Human Investigation Knowledge Lead Learning Mediator Medical Methodology Molecular Target Morbidity - disease rate New Mexico Onset of illness Operative Surgical Procedures Organ Outcome Pathogenesis Patients Population Process Research Research Personnel Scientist Signal Pathway Techniques Technology Therapeutic Agents Tissue Engineering Tissue Model Tissues Translating Translations Tungsten Vascular Diseases Work aging population cardiac repair cardiac tissue engineering cardiogenesis clinical application clinical practice congenital heart disorder design improved in vitro Model in vivo Model inherited cardiomyopathy innovation insight interest meetings mortality novel novel strategies novel therapeutics posters programs regenerative biology regenerative therapy stem cell model stem cells symposium therapeutic development therapy development tool translational therapeutics treatment strategy

Acceleration Address Adult Animal Disease Models Animal Model Biology Biophysics Cardiac Cardiac Myocytes Cardiovascular Diseases Cardiovascular system Cell Therapy Cell model Cells Child Clinical Trials Collaborations Development Developmental Biology Disadvantaged Disease Disease Progression Disease model Educational workshop Event Fertilization Functional disorder Genes Genetic Goals Health Expenditures Heart Heart Diseases Human Investigation Knowledge Lead Learning Mediator Medical Methodology Molecular Target Morbidity - disease rate New Mexico Onset of illness Operative Surgical Procedures Organ Outcome Pathogenesis Patients Population Process Research Research Personnel Scientist Signal Pathway Techniques Technology Therapeutic Agents Tissue Engineering Tissue Model Tissues Translating Translations Tungsten Vascular Diseases Work aging population cardiac repair cardiac tissue engineering cardiogenesis clinical application clinical practice congenital heart disorder design improved in vitro Model in vivo Model inherited cardiomyopathy innovation insight interest meetings mortality novel novel strategies novel therapeutics posters programs regenerative biology regenerative therapy stem cell model stem cells symposium therapeutic development therapy development tool translational therapeutics treatment strategy

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项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Heart Development and Disease: From Genes to Cures, organized by Drs. Sean Wu, Wolfram Zimmermann and Christine Seidman. The conference will be held in Santa Fe, New Mexico from February 12-15, 2023. Significant advances in recent years in mechanistic understanding of cardiac development, function, and degeneration have stimulated interest in identifying novel therapeutic agents that may help treat children and adult patients with cardiovascular diseases. However, therapies developed in cell and animal models rarely translate well to human patients. The goals of this conference are to advance our understanding of heart formation and homeostatic function and how derangement in these processes lead to diseases and organ dysfunction. Since human cardiovascular tissue is difficult to obtain for experimental perturbation this conference will address the use of a spectrum of cells and engineered tissue models as well as small and large animal models of disease. This conference will also feature the state-of-the art tools and technologies that have revolutionized the developments in various domains of cardiovascular research including heart developmental biology, genetics of cardiomyopathy and congenital heart disease, cardiac tissue engineering, and cell and regenerative therapy. This event will bring together scientists with diverse research backgrounds who employ different tools and technologies to address mechanisms of cardiomyocyte and vascular dysfunction and will uncover new approaches to cardiovascular biology. The program is designed to showcase innovative, molecularly targeted strategies to treat both rare and common cardiovascular diseases.

抽象的请求支持Keystone研讨会会议，名为“心脏发育和疾病：来自由Drs组织的基因。 Sean Wu，Wolfram Zimmermann和Christine Seidman。会议将于2023年2月12日至15日在新墨西哥州圣达菲举行。近年来，在对心脏发展，功能和机械理解方面的显着进步堕落引起了人们对识别新型治疗剂的兴趣，这些治疗剂可能有助于治疗儿童和成年患有心血管疾病的患者。但是，在细胞和动物模型中开发的疗法很少很好地转化为人类患者。这次会议的目标是提高我们对心脏的理解形成和稳态功能以及这些过程中的危险如何导致疾病和器官功能障碍。由于人体心血管组织很难实现扰动会议将解决一系列细胞和工程组织模型以及大小的使用疾病动物模型。这次会议还将采用最先进的工具和技术已经彻底改变了心血管研究各个领域的发展发育生物学，心肌病和先天性心脏病的遗传学，心脏组织工程，和细胞和再生疗法。该活动将汇集具有多种研究背景的科学家谁采用不同的工具和技术来解决心肌细胞和血管的机制功能障碍，并将发现新的心血管生物学方法。该程序旨在展示创新的，分子靶向的策略，以治疗稀有和常见的心血管疾病。