Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing

通过 2 光子增材制造实现超稳定、相敏、快照 OCT 系统

• 批准号: 10607853
• 负责人: Brian E. Applegate
• 金额: $ 25.07万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10607853
• 关键词: 3-Dimensional; 3D Print; Air; Angiography; Biological; Biomedical Research; Cardiology; Clinical; Collaborations; Collection; Complex; Custom; Data Set; Dermatology; Development; Devices; Endoscopes; Endoscopy; Event; Feasibility Studies; Funding; Gastroenterology; Goals; Image; Imaging Techniques; Iris; Lateral; Maps; Masks; Measurement; Methods; Modality; Monitor; Morphologic artifacts; Motion; Multimodal Imaging; Ophthalmology; Optical Coherence Tomography; Optics; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Predisposition; Printing; Process; Research; Resolution; Rice; Risk; Sampling; Scanning; Series; Source; Spectrum Analysis; Speed; Structure; System; Systems Integration; Techniques; Technology; Testing; Therapeutic; Three-Dimensional Imaging; Tissues; Validation; With laterality; Work; adaptive optics; analog; body cavity; clinical application; clinical diagnosis; cost; design; detector; digital; elastography; experimental study; fabrication; innovative technologies; instrument; interest; lens; manufacture; miniaturize; nanoscale; new technology; novel; polymerization; pre-clinical; programs; quantum; response; scale up; sensor; technology development; technology platform; technology research and development; two-photon; vibration

In this proposal we aim to build a platform technology for volumetric OCT snapshot imaging using principle of Image Mapping Spectroscopy. We will demonstrate Full Field Spectral Domain OCT ((FFSDOCT)) system in free space. The volumetric functional OCT will be enabled by leveraging advanced 2Photon Polymerization 3-D printing approaches, that will permit printing of arbitrary optical quality structures. To achieve these goals, we will utilize state of the art Quantum X system from Nanoscribe. The device allows the combination of small, and medium size detail allowing feature sizes down to 140 nm. The roughness obtained in the printing process is below 20 nm. Prints will be performed in clear resins (IV-Dip, SU8 analogs etc.). It also permits unprecedented print volumes in comparison to other 2PP printers. Specifically, the proof of concept Full Field Spectral Domain OCT will use custom designed 3-D printed multifaceted mirror imaged and dispersed onto a 2-D sCMOS sensor. The mapping mirror will incorporate 10,000 miniature facets and 100 unique tilts to map 100x100 image points onto a camera sensor. In result the system will operate as an array of parallel, high resolution spectrometers where the number of spectrometers equals the number of object points. The resulting FFSDOCT system will have no moving parts yet be capable of acquiring volumetric OCT images at the frame rate of the sensor (30 Hz). The imaging spectrometer will linearly sample in wavenumber. To evaluate system, we will perform series of imaging experiments in free space. FFSDOCT will be characterized for resolution, system sensitivity, the measurement of flow and nanoscale vibrations.

在此提案中，我们旨在建立一种平台技术，用于使用原理 图像映射光谱。我们将在免费的 空间。体积功能OCT将通过利用高级2Photon聚合3-D实现 打印方法，这将允许打印任意的光学质量结构。为了实现这些目标，我们 将利用Nanoscribe的最先进的量子X系统。该设备允许小型和 中等大小的细节，功能尺寸降低至140 nm。在打印过程中获得的粗糙度是 低于20 nm。印刷品将在透明树脂（IV-DIP，SU8类似物等）中进行。它也允许前所未有的 与其他2PP打印机相比，打印量。 具体而言，概念证明全场光谱域OCT将使用定制设计的3D打印 成像的多方面镜子并分散到2-D SCMOS传感器上。映射镜将合并 10,000个微型面和100个独特的倾斜度，将100x100图像点映射到相机传感器上。结果 系统将作为平行，高分辨率光谱仪的阵列，其中光谱仪数量 等于对象点的数量。由此产生的FFSDOCT系统将尚无动机部件 以传感器的帧速率（30 Hz）获取体积OCT图像。成像光谱仪将线性线性 在波数中样品。 为了评估系统，我们将在自由空间中执行一系列成像实验。 FFSDOCT将被描述 为了分辨，系统灵敏度，流量和纳米级振动的测量。