Multi-parametric anthropomorphic MRI Phantoms technology for reliable and reproducible structural and quantitative MRI

多参数拟人 MRI Phantoms 技术可实现可靠且可重复的结构和定量 MRI

• 批准号: 10729161
• 负责人: Ana Claudia Arias
• 金额: $ 61.04万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-08 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729161
• 关键词: 3-Dimensional; 3D Print; Acceleration; Address; Air; Anatomy; Biological; Brain; Chemicals; Clinic; Clinical; Collaborations; Color; Crosslinker; Data Science; Defect; Development; Diffusion; Educational workshop; Ensure; Equipment; Evaluation; Exhibits; Fatty acid glycerol esters; Fingerprint; Gel; Geometry; Head; Healthcare; Heterogeneity; Human; Hydrogels; Image; Imaging Phantoms; Industrialization; Internet; Liquid substance; Machine Learning; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Methods; Modeling; Paper; Permeability; Plastics; Predisposition; Printing; Process; Property; Protons; Publishing; Quality Control; Recommendation; Relaxation; Reproducibility; Resolution; Scanning; Shapes; Shoulder; Signal Transduction; Site; Slice; Source; Speed; Standardization; Structure; Techniques; Technology; Testing; Thinness; Time; Tissues; Variant; Viscosity; Water; Work; biomarker discovery; bone; clinical translation; deep learning; density; design; digital; digital twin; fabrication; human subject; improved; manufacture; manufacturing process; millimeter; monomer; novel strategies; personalized diagnostics; precision medicine; reconstruction; skills; sound; three dimensional structure; tool; validation studies

Abstract We aim to develop tools for ground-truth phantoms for quantitative and structural MRI (qMRI). qMRI aims to acquire maps of physical or chemical variables that can be measured in physical units and compared between tissue regions and among subjects. In contrast, most clinical MRI acquisitions are only qualitative, i.e. “weighted images”, and not quantitative. While qMRI has the potential to improve precision diagnostics and medicine, it has been traditionally hampered by significant barriers such as imaging speed, computational practicalities, and reproducibility and repeatability of MR measurements. The variability between scanners and human subjects and the lack of ground truth in biological tissues fundamentally challenge the development, testing and standardization of qMRI techniques. The National Institute of Standards and Technology (NIST) hosted workshops working towards standardizing qMRI. The resulting recommendation paper highlighted a list of outstanding needs. The proposed project aims to address these unmet needs by developing materials, technology, tools and processes for manufacturing quantitative anthropomorphic MRI phantoms. Current state- of-the-art solutions for manufacturing MRI phantoms often use discrete compartments or geometrical shapes filled with chemical solutions representing a single physical parameter. In contrast, our proposed novel approach will enable fabrication of phantoms that truly mimic the contrast heterogeneity of tissue in 3D. These will include proton density, T1, T2, T2* relaxation times, magnetic susceptibility, diffusion, fat fraction, air-tissue field- inhomogeneity, relative conductivity, electric permittivity and magnetic permeability. If successful, this will be the first time that such a comprehensive set of MRI parameters is accomplished in a tissue-mimicking phantom. Based on our preliminary work on quantitative anatomy mimicking slice phantoms, we propose two approaches: (a) Quantitative 3D stack of thin slices. This approach is inexpensive, easy to reproduce by labs with moderate equipment and skills. (b) An advanced approach of boundaryless fully 3D phantoms that will be fabricated via inkjet 3D printing of hydrogels and plastics and would enable true high resolution 3D structures with heterogeneity that mimics human anatomy. In collaboration with leading industrial partners, we will validate and disseminate our technology. Our proposal is motivated by a rising need for quantitative measurements in MRI driven by precision medicine and the use of data science tools for biomarker discovery. With the rise of methods such as fingerprinting, and accelerated reconstruction, quantitative MRI (qMRI) is closer to the clinics than ever. The proposed quantitative MRI phantom will mimic the complexity of tissue structure and contrast mechanism that are necessary to ensure the accuracy of qMRI. If successful, the project will greatly facilitate the development and clinical translation of qMRI, making MRI accurate, precise, and quantitative – thus enabling precision diagnostic and discoveries that will directly improve healthcare.

抽象的 我们旨在开发用于定量和结构MRI（QMRI）的基础真相幻象的工具。 QMRI的目标是 获取可以在物理单位中测量并进行比较的物理或化学变量的地图 组织区域以及受试者之间。相反，大多数临床MRI获取仅是定性的，即“加权 图像”，而不是定量。尽管QMRI有可能改善精度诊断和医学 传统上，诸如成像速度，计算实践和 MR测量的可重复性和可重复性。扫描仪和人类受试者之间的变异性 并且在生物组织中缺乏地面真理从根本上挑战了发展，测试和 QMRI技术的标准化。国家标准技术研究所（NIST）主持 旨在标准化QMRI的研讨会。由此产生的推荐论文突出了一份清单 出色的需求。拟议的项目旨在通过开发材料来满足这些未满足的需求， 制造定量拟人化MRI幻象的技术，工具和过程。当前状态 - 制造MRI幻象的ART解决方案通常使用离散隔室或几何形状 充满了代表单个物理参数的化学溶液。相比之下，我们提出的新方法 将实现真正模仿3D组织的对比异质性的幻象。这些将包括 质子密度，T1，T2，T2*松弛时间，磁敏感性，扩散，脂肪分数，空气组织场 - 不均匀性，相对电导率，电介电常数和磁渗透性。如果成功，这将是 首次在模拟组织的幻影中完成了如此全面的MRI参数。 根据我们关于模仿切片幻影的定量解剖学的初步工作，我们提出了两种方法： （a）定量3D薄片。这种方法是廉价的，易于通过现代实验室繁殖 设备和技能。 （b）无边界完全3D幻影的先进方法，该方法将通过 喷墨3D打印水凝胶和塑料，将使真正的高分辨率3D结构与 模仿人体解剖结构的异质性。与领先的工业合作伙伴合作，我们将验证和 传播我们的技术。我们的建议是由于对MRI进行定量测量的需求不断增加的动机 由精确医学和使用数据科学工具用于生物标志物发现的驱动。随着方法的兴起 例如指纹和加速重建，定量MRI（QMRI）比以往任何时候都更接近诊所。 拟议的定量MRI幻影将模仿组织结构的复杂性和对比机制 确保QMRI的准确性是必要的。如果成功，该项目将极大地支持开发 QMRI的临床翻译，使MRI准确，精确和定量 - 从而实现精度 诊断和发现将直接改善医疗保健。