Ingestible gastric-resident electronic metamaterials architecture (iGEM) for the treatment of obesity

用于治疗肥胖症的可摄入胃驻留电子超材料架构（iGEM）

基本信息

批准号：
10688246
负责人：
YONG LIN KONG
金额：
$ 34.28万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10688246
关键词：
3-Dimensional 3D Print Abdominal Pain Adult Affect Air Animal Model Architecture Biochemical Body Weight Body Weight decreased Cardiovascular Diseases Chemicals Chronic Disease Clinical Clinical Research Complex Consumption Data Devices Diabetes Mellitus Dissociation Doctor of Philosophy Dosage Forms Effectiveness Electric Capacitance Electronics Eligibility Determination Endoscopy Environment Excision Excretory function Feedback Feeling Foundations Gastric Balloon Goals Healthcare Hybrids Hypertension Implant Intervention Intestinal Obstruction Magnetism Measurement Measures Mechanics Metabolic Methodology Monitor Morbidity - disease rate Nausea Obesity Obesity associated disease Operative Surgical Procedures Oral Oral Ingestion Outcome Patient Selection Patients Perforation Performance Printing Quality of life Reflux Reporting Research Risk Risk Factors Rupture Safety Saline Satiation Serious Adverse Event Stents Stomach Structure System Temperature Time Treatment Effectiveness Ulcer Vomiting Work bariatric surgery biomaterial compatibility cost design digital experience gastrointestinal symptom improved invention novel obesity treatment porcine model premature pressure pressure sensor prevent programs rational design residence sensor simulation treatment strategy wireless wireless sensor

项目摘要

Project Summary Obesity affects more than 1.4 billion adults worldwide and is a significant risk factor for chronic diseases such as hypertension, diabetes, and cardiovascular diseases. Present non-operative treatment options of obesity are woefully inadequate. Bariatric surgery is effective but invasive, costly, and associated with significant morbidity. Intragastric balloons (IGB) have been demonstrated to be effective in enabling temporary weight loss (~25-30% of excess body weight), allowing the improvement of metabolic parameters. However, IGB is a passive mechanical construct that cannot be monitored or controlled upon insertion and require endoscopy delivery. These fundamental attributes limit the reach of IGB to very selected patients as a temporary treatment or as a bridging intervention to bariatric surgery despite its effectiveness. The proposed research will overcome the fundamental limitations of IGB by creating an ingestible gastric-resident electronic-enhanced metamaterial architecture (iGEM). In stark contrast to the current strategies, iGEM can transform obesity treatment with a digital-based personalized and dynamic treatment strategy. iGEM allows the dynamic tuning of gastric restrictive effect, which can be optimized based on safety consideration, patient’s treatment goals, and the quality of life desired. For example, feedback-based control of the device distension can prevent excessive pressure point or over-inflation that may lead to ulcer formation; or to avoid intestinal obstruction due to premature disintegration. The ability to adjust gastric restrictive pressure can enhance treatment effectiveness to account for gastric accommodation. The ability to acquire sensing data can help elucidate the complex relationship between the restrictive effect of intragastric devices and treatment effectiveness. This research leverages Kong’s expertise in creating entirely 3D printable electronics and ingestible electronics, (2) Wang’s (Ph.D.) expertise in meta- materials design, and (3) Fang’s (M.D.) extensive clinical and clinical research experience in IGB usage and intragastric devices. Specifically, we will (1) develop wireless resonant-enhanced 3D printable gastric pressure sensors with a hybrid core-shell printing methodology that allow the integration of pressure sensors on a wide range of intragastric systems; (2) develop wirelessly triggered transformable active metamaterials architecture that is capable of achieving wirelessly triggered reversible structural reconfiguration, allowing the oral ingestion of the device, dynamic control of expansion to tailor gastric restriction effect and the safe excretion of the device without risk of intestinal obstruction; (3) develop and evaluate iGEM longitudinal wireless pressure sensing and triggerable volume control capability that can sustain the complex and dynamic gastric environment for a prolonged period of time (30 days). Upon completion of the proposed research, the foundation established by this proposed work is also applicable to include a wide range of inductance/capacitance-based sensors (temperature, biochemical, bacterial), as well as various ingestible or implantable systems such as stents, enabling multivariate longitudinal sensing and unprecedented control.

项目摘要肥胖症影响着全球超过14亿的成年人，是慢性疾病的重要危险因素作为高血压，糖尿病和心血管疾病。肥胖的目前的非手术治疗选择是悲惨地不足。减肥手术是有效的，但具有侵入性，昂贵，并且与明显的发病率有关。胃内气球（IGB）已被证明可以有效造成临时体重减轻（〜25-30％体重过大），可以改善代谢参数。但是，IGB是被动的在插入时无法监测或控制的机械构造并需要内窥镜递送。这些基本属性将IGB的影响限制为非常选择的患者作为临时治疗或作为一种将干预措施桥接到减肥手术中迫切有效。拟议的研究将克服 IGB的基本局限建筑（IGEM）。与当前的策略形成鲜明对比，IGEM可以通过基于数字的个性化和动态治疗策略。 IGEM允许动态调整胃限制性效果，可以根据安全考虑，患者的治疗目标和生活质量进行优化需要。例如，基于反馈的设备扩张的控制可以防止压力点过多或过度充气，可能导致溃疡形成；或避免由于过早瓦解而引起的肠道异议。调节胃限制压力的能力可以提高治疗有效性以考虑胃住宿。获取传感数据的能力可以帮助阐明胃内装置和治疗效果的限制性作用。这项研究利用了孔的专业知识在创建完全3D可打印的电子和可设备的电子产品时，（2）Wang's（Ph.D.）Meta-- 材料设计，以及（3）Fang（M.D.）IGB使用方面的广泛临床和临床研究经验胃内设备。特别是，我们将（1）发展无线谐振3D可打印胃压具有混合芯壳打印方法的传感器，允许在宽度上集成压力传感器胃内系统范围；（2）开发无线触发可转换的活动超材料体系结构能够实现无线触发可逆的结构重新配置，使口服摄入设备的动态控制对量身定制胃限制效果的动态控制和设备的安全排泄没有肠道异议的风险；（3）开发和评估IGEM纵向无线压力感测和可触发的体积控制能力，可以维持复杂而动态的胃环境长时间的时间（30天）。拟议研究完成后，基金会建立了这项提出的工作也适用于包括各种电感/电容传感器（温度，生化，细菌）以及各种可植入或植入系统（例如支架）实现多元纵向感应和前所未有的控制。