The Effect of Pubertal Hormones on theDevelopment of Neural Oscillatory Dynamics in Youth

青春期激素对青少年神经振荡动力学发育的影响

• 批准号: 10605727
• 负责人: Abraham Killanin
• 金额: $ 4.16万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-13 至 2026-09-12
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605727
• 关键词: Academic achievement; Address; Adolescence; Adolescent; Affect; Affective; Age; Animals; Anxiety; Area; Attention; Behavior; Behavioral; Brain; Brain Mapping; Child; Childhood; Chronology; Clinical Skills; Cognition; Cognitive; Data; Dendritic Spines; Development; Development Plans; Disease; Doctor of Philosophy; Emotional; Estradiol; Event; Fellowship; Female; Foundations; Future; Goals; Gonadal Hormones; Gonadal Steroid Hormones; Hair; Hormonal Change; Hormones; Hospitals; Human; Incidence; Individual; Insula of Reil; International; Journals; Knowledge; Laboratories; Life; Link; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Magnetoencephalography; Manuscripts; Measures; Medical center; Mental Depression; Mental disorders; Mentors; Methods; Minority; Nebraska; Neurophysiology - biologic function; Neurosecretory Systems; Parietal; Participant; Performance; Physicians; Plasma; Prevalence; Proxy; Psychiatry; Psychopathology; Puberty; Reaction Time; Recording of previous events; Research; Research Design; Research Support; Rodent Model; Role; Sampling; Scientist; Sex Differences; Short-Term Memory; Socioeconomic Status; Source; Structure; Sum; Symptoms; Testing; Testosterone; Training; Universities; Visuospatial; Work; Youth; age effect; base; boys; career; career development; cognitive development; cognitive enhancement; cognitive function; cognitive neuroscience; cognitive system; critical period; dehydroepiandrosterone; density; design; doctoral student; frontier; gray matter; imaging study; improved; male; memory process; neural circuit; neural network; neurodevelopment; neuroimaging; programs; puberty transition; reconstruction; relating to nervous system; research and development; selective attention; sex; statistics; symposium

Project Summary This application describes the research plan and program of study leading to a PhD as part of a combined MD- PhD Program at the University of Nebraska Medical Center and the Boys Town National Research Hospital. The central goal of this research plan is to identify how dehydroepiandrosterone (DHEA), testosterone, and estradiol modulate the development of cognitive systems serving selective attention and working memory processing. Briefly, the pubertal transition period is marked by significant increases in these hormones and substantial developmental advancements in higher-order cognitive functions, including working memory, selective attention, and others. However, on the other hand, the incidence of psychiatric disease also increases during puberty, and is accompanied by greater sex differences in disease prevalence. It has been suggested that this emergence of psychiatric illness during puberty might be associated with the drastic hormonal changes that mark this developmental stage, but the net impact of these hormonal changes on brain function and cognition is poorly understood. This F30 fellowship proposal will examine the sex and region-specific effects of DHEA, testosterone, and estradiol on working memory and selective attention processing using an advanced dynamic functional mapping approach based on magnetoencephalography (MEG), and includes a rigorous training and career development plan for a future physician-scientist in the areas of pediatric psychiatry and developmental cognitive neuro- science. The specific aims are (1) to examine the unique effects of pubertal hormones in predicting performance on selective attention and working memory tasks and (2) to identify the relationship between sex steroid hormone levels, neural oscillatory dynamics, and behavior during attention and working memory tasks. The trainee is a minority MD/PhD student in his 2nd year of PhD study who has already distinguished himself through two first- authored manuscripts in top journals, participation and presentation in scientific conferences, and a strong history of academic achievement. In sum, this application for an F30 fellowship will use MEG, advanced source reconstruction methods, neural oscillatory analyses, and hair-sampled hormone analysis to delineate the relationship between pubertal hormone levels, brain dynamics, and cognitive development. The program of study is designed to support this research plan through rigorous training by an internationally known expert in MEG and dynamic brain mapping who has a strong record of mentoring trainees, as well as an expert collaborator in pubertal hormone analysis and interpretation, with the primary goals of developing and expanding the research and clinical skills of the applicant to produce a physician-scientist who is well equipped and prepared for the next stage of his career.

项目摘要 该应用程序描述了研究计划和研究计划，导致博士学位作为合并的MD-的一部分 内布拉斯加州大学医学中心和男孩镇国家研究医院的博士课程。这 该研究计划的核心目标是确定脱氢表雄酮（DHEA），睾丸激素和雌二醇如何 调节认知系统的开发，以提供选择性关注和工作记忆处理。 简而言之，青春期过渡时期的特征是这些激素显着增加和大量 高阶认知功能的发展进步，包括工作记忆，选择性关注， 还有其他。但是，另一方面，精神病的发生率也在青春期和 伴随着疾病患病率的性别差异更大。有人建议这种出现 青春期期间的精神病可能与标志着这一点的激素变化有关 发展阶段，但是这些激素变化对脑功能和认知的净影响很差 理解。 该F30奖学金提案将检查DHEA，睾丸激素和 使用高级动态功能映射的雌二醇在工作记忆和选择性注意处理上 基于磁脑电图（MEG）的方法，包括严格的培训和职业发展 计划在儿科精神病学和发育认知神经 - 科学。具体目的是（1）检查青春期激素在预测性能方面的独特影响 关于选择性注意力和工作记忆任务以及（2）确定性类固醇激素之间的关系 关注和工作记忆任务期间的水平，神经振荡动力学以及行为。实习生是 少数族裔医学博士/博士生在第二年的博士学位学习中，他已经通过两个首先出名 在顶级期刊，科学会议的参与和演讲中撰写了手稿，并有很强的历史 学术成就。总而言之，F30奖学金的此应用将使用MEG，高级来源 重建方法，神经振荡分析和头发采样的激素分析，以描绘 青春期激素水平，大脑动力学和认知发展之间的关系。研究计划 旨在通过国际知名专家在MEG的严格培训来支持该研究计划 和动态的大脑映射，他在指导学员方面都有很强的记录，以及专家合作者 青春期激素分析和解释，其主要目标是发展和扩展研究 以及申请人的临床技能，生产一名医生科学家，他们为下一个准备好准备并做好准备 他职业生涯的阶段。