Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation

ADHD 中的阿尔法振荡和工作记忆缺陷：多模态成像研究

• 批准号: 10808640
• 负责人: Agatha Lenartowicz
• 金额: $ 12.35万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-30 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10808640
• 关键词: Academic achievement; Address; Adolescence; Adolescent; Attention; Attention deficit hyperactivity disorder; Attentional deficit; Biological Markers; Brain; Characteristics; Child; Clinical; Development; Electroencephalography; Event; Heterogeneity; High Prevalence; Individual; Investigation; Life; Measures; Memory impairment; Methodology; Multimodal Imaging; Outcome; Outcomes Research; Participant; Patients; Performance; Process; Quality of life; Sampling; Short-Term Memory; Specificity; Testing; Visual attention; effective therapy; follow-up; functional magnetic resonance imaging/electroencephalography; improved; indexing; insight; memory encoding; neural; neuromechanism; neurophysiology; neuropsychiatric disorder; novel; recruit; societal costs

Project Summary High prevalence rates of attention deficit hyperactivity disorder (ADHD) (5-11% of children 4-17 years), combined with its high societal cost, strong persistence and pernicious effects on quality of life, warrant continued efforts to understand its underlying neural mechanisms. Underscoring this need is the increasing recognition that ADHD is clinically and mechanistically heterogeneous, and that this likely degrades the reliability of putative biomarkers of ADHD. Novel, focused studies that aim to reduce such heterogeneity are needed. In this project, we aim to define a robust, relatively unexplored putative biomarker of visual attention deficits, alpha range (8-12Hz) event-related decrease (ERD), which strongly indexes working memory (WM) deficits in ADHD. Using cutting-edge, concurrent EEG-fMRI recordings, we propose to measure event-related alpha ERD and its associated brain activation and network connectivity during WM encoding. The concurrent recordings allow us to directly test if fluctuations in engagement of attention mechanisms captured by the alpha ERD neurophysiological measures predict fluctuations in WM neural processes. Using this methodology, we aim to: (a) identify neural mechanisms underlying alpha ERD deficits and WM performance in ADHD, and (b) define the clinical features of alpha ERD deficits in ADHD, including its effect on real life outcomes such as academic achievement. Unique to this project, we will sample participants who were previously tested in two large ADHD-EEG studies, recruiting them for a longitudinal follow-up experimental session if they are currently in adolescence (14-18 years). By doing so we aim to (c) characterize the developmental trajectory of attention deficits as captured by alpha ERD in ADHD, as well its impact on the trajectory of clinical and real-life outcomes. The adolescent sample will provide new insight into neural and neurophysiological characteristics of ADHD during this developmental period. The outcome of this research is a clearly defined neural mechanism, alpha ERD, that can be targeted in treatment of WM deficits in ADHD, or in other neuropsychiatric disorders.

项目摘要 注意力缺陷多动障碍（ADHD）的高患病率（4-17岁儿童的5-11％）， 结合其高昂的社会成本，强大的持久性和对生活质量的有害影响，认股权证 继续努力了解其潜在的神经机制。强调这种需求是增加 认识到ADHD在临床和机械上是异质的，这可能会降低 ADHD推定生物标志物的可靠性。旨在减少这种异质性的新颖，重点的研究是 需要。在这个项目中，我们旨在定义一个可观的，相对尚未探索的视觉关注的假定生物标志物 缺陷，Alpha范围（8-12Hz）事件相关的减小（ERD），它强烈索引工作记忆（WM） 多动症中的缺陷。使用尖端的，并发的EEG-FMRI记录，我们建议测量与事件相关的 WM编码期间的Alpha ERD及其相关的大脑激活和网络连接。并发 录音使我们能够直接测试Alpha捕获的注意机制的参与度的波动 ERD神经生理学措施预测了WM神经过程中的波动。使用这种方法，我们 目的是：（a）确定ADHD中αERD缺陷和WM表现的神经机制，以及（b） 定义ALPHA ERD缺陷的临床特征，包括其对现实生活结果的影响 学术成就。该项目独有的是，我们将对以前在两个中进行过测试的参与者进行采样 大型ADHD-EEG研究，招募它们进行纵向随访实验，如果它们目前是 在青春期（14-18岁）。通过这样做，我们的目标是（c）表征关注的发展轨迹 Alpha Erd在多动症中捕获的缺陷，以及其对临床和现实生活轨迹的影响 结果。青少年样本将为神经和神经生理特征提供新的见解 在此发展时期的多动症。这项研究的结果是明确定义的神经机制， Alpha ERD，可以针对多动症的WM缺陷或其他神经精神疾病的治疗。

项目成果

Methylphenidate, Guanfacine, and Combined Treatment Effects on Electroencephalography Correlates of Spatial Working Memory in Attention-Deficit/Hyperactivity Disorder.

哌醋甲酯、胍法辛和联合治疗对注意力缺陷/多动障碍中空间工作记忆的脑电图相关性的影响。

• DOI: 10.1016/j.jaac.2022.06.017
• 发表时间: 2023
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Michelini,Giorgia;Lenartowicz,Agatha;Diaz-Fong,JoelP;Bilder,RobertM;McGough,JamesJ;McCracken,JamesT;Loo,SandraK
• 通讯作者: Loo,SandraK

Neurocognitive subprocesses of working memory performance.

• DOI: 10.3758/s13415-021-00924-7
• 发表时间: 2021-12
• 期刊: Cognitive, affective & behavioral neuroscience
• 作者: Lenartowicz A;Truong H;Enriquez KD;Webster J;Pochon JB;Rissman J;Bearden CE;Loo SK;Bilder RM
• 通讯作者: Bilder RM

Treatment biomarkers for ADHD: Taking stock and moving forward.

• DOI: 10.1038/s41398-022-02207-2
• 发表时间: 2022-10-12
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Michelini, Giorgia;Norman, Luke J.;Shaw, Philip;Loo, Sandra K.
• 通讯作者: Loo, Sandra K.

A new era for executive function research: On the transition from centralized to distributed executive functioning.

• DOI: 10.1016/j.neubiorev.2021.02.011
• 发表时间: 2021-05
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Zink N;Lenartowicz A;Markett S
• 通讯作者: Markett S

Electrophysiological and Clinical Predictors of Methylphenidate, Guanfacine, and Combined Treatment Outcomes in Children With Attention-Deficit/Hyperactivity Disorder.

哌醋甲酯、胍法辛以及注意力缺陷/多动症儿童联合治疗结果的电生理学和临床预测因素。

• DOI: 10.1016/j.jaac.2022.08.001
• 发表时间: 2023
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Michelini,Giorgia;Lenartowicz,Agatha;Vera,JuanDiego;Bilder,RobertM;McGough,JamesJ;McCracken,JamesT;Loo,SandraK
• 通讯作者: Loo,SandraK