Epigenetic aging, social factors, and preterm birth among Black women

黑人女性的表观遗传衰老、社会因素和早产

• 批准号: 10605694
• 负责人: Carmen Giurgescu
• 金额: $ 73.19万
• 依托单位: UNIVERSITY OF CENTRAL FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-18 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605694
• 关键词: 37 weeks gestation; Acceleration; Address; Age; Age Years; Aging; Area; Biological; Biological Aging; Biological Markers; Birth; Black Populations; Black race; Blood; Blood specimen; COVID-19 pandemic; Cell Aging; Chronic stress; Chronology; Coupled; Crime; DNA; DNA Methylation; Data; Disease; Enrollment; Epigenetic Process; Genetic; Gestational Age; Goals; Individual; Individual Differences; Infant; Infant Mortality; Length; Life Experience; Maternal Age; Measures; Medical Records; Methylation; Neighborhoods; Not Hispanic or Latino; Participant; Pattern; Performance; Precision Health; Pregnancy; Pregnant Women; Premature Birth; Prevention; Publishing; Questionnaires; Race; Reporting; Research; Ribosomal DNA; Ribosomes; Risk; Risk Assessment; Risk Factors; Saliva; Sampling; Shapes; Term Birth; Weather; Whole Blood; Woman; Work; age related; bisulfite sequencing; black men; black women; case control; cohort; design; driving force; experience; high risk; inter-individual variation; metropolitan; neighborhood disadvantage; novel; prevent; racial discrimination; racism; social factors; social stressor; systematic review; telomere; therapeutic target

PROJECT ABSTRACT Preterm birth (PTB; <37 weeks gestation) is the leading cause of infant mortality among Black infants. Maternal chronological age has long been used to assess risk for PTB; however, chronological age assumes that individuals age at similar rates and does not capture the inter-individual differences that may exist due to race. Although both Black and White women have a maternal age-related increase in PTB, the risk for PTB is higher among Black women than among White women at all maternal ages. Geronimus’ weathering hypothesis describes a pattern in which age-related increases in PTB occur at a younger age for Black women, and risk with age increases in a linear pattern, rather than the J- shaped association with chronological age overall. This acceleration of aging has been attributed to Black women being more likely to experience chronic stress due to social stressors of racial discrimination and neighborhood disorder and crime. Epigenetic age, a measure of cellular or biological aging, reflects influences of past exposures and may be more useful in determining risk for PTB than chronological age, which is uniform regardless of life experiences. However, research is lacking on (1) the association of social stressors with epigenetic aging among Black pregnant women; and (2) the association of epigenetic aging with PTB among these women. This study is designed to address the gaps in prior research and relies on our previous work demonstrating that ribosomal DNA methylation (rDNAm) harbors the rDNA clock, a novel, sensitive, and evolutionarily conserved clock of epigenetic aging. The goal of this study is to examine epigenetic aging as a marker of social stressors and a biomarker indicating risk of PTB among Black women. Our cohort is comprised of 550 Black pregnant women enrolled prior to the COVID-19 pandemic from the Detroit, MI and Columbus, OH areas (R01 MD011575, PI Giurgescu). Women completed questionnaires and provided whole blood samples and saliva during pregnancy, and these biological samples will be used to complete the proposed study. Maternal medical records have been abstracted. We aim to: (Aim 1) Determine whether social stressors are associated with an accelerated rDNAm clock among Black pregnant women; (Aim 2) Determine whether women with PTB have an accelerated rDNAm clock compared with women with term birth; and (Aim 3) Assess performance of the rDNAm clock associated with PTB relative to alternative metrics of epigenetic aging. Epigenetic age, a biological reflection of inter- individual variability in aging, holds significant potential as a useful parameter in PTB prevention from a precision health perspective. Currently, the ability to predict PTB is poor, especially among Black women. Precision health has the potential to identify individual women who are at risk for PTB, and to identify therapeutic targets to prevent an individual from having PTB.

项目摘要 早产（PTB； <37周妊娠）是黑人婴儿死亡的主要原因。 长期以来，孕产妇的年代年龄已被用来评估PTB的风险；但是，年代年龄 假设个体以相似的速度年龄，并且不会捕获个体间差异 可能由于种族而存在。尽管黑人和白人妇女均与年龄有关 PTB，黑人妇女中PTB的风险高于所有物质年龄的白人妇女。 Geronimus的风化假说描述了一种模式，在PTB中发生与年龄相关的增长 黑人妇女的年龄很小，随着年龄的增长，风险会增加线性模式，而不是J- 与年龄总体年龄的形状关联。这种衰老的加速已归因于 由于种族的社会压力，黑人妇女更有可能遭受慢性压力 歧视，邻里障碍和犯罪。表观遗传时代，衡量细胞或 生物衰老，反映了过去暴露的影响，可能在确定的风险方面更有用 PTB比年龄年龄段，无论生活经历如何，它都是统一的。但是，研究是 缺乏（1）黑人孕妇的社会压力与表观遗传衰老的关联； （2）这些妇女中表观遗传衰老与PTB的关联。这项研究旨在 解决先前研究的差距，并依赖我们以前的工作，证明了核糖体DNA 甲基化（RDNAM）携带rDNA时钟，这是一种新颖，敏感和进化的配置时钟 表观遗传衰老。这项研究的目的是检查表观遗传衰老作为社会压力源的标志 以及表明黑人妇女PTB风险的生物标志物。我们的队列完成了550黑色 孕妇在底特律，密歇根州和哥伦布的COVID-19大流行之前就读于俄亥俄州 区域（R01 MD011575，Pi Giurgescu）。妇女填写问卷并提供了全血 怀孕期间的样品和唾液，这些生物样品将用于完成 拟议的研究。孕产妇的病历已被抽象。我们的目标是：（目标1）确定 社会压力源是否与黑色孕妇的加速RDNAM时钟相关 女性; （AIM 2）确定与PTB的女性相比是否具有加速RDNAM时钟 与有期育期的妇女； （目标3）评估与PTB相关的RDNAM时钟的性能 相对于表观遗传衰老的替代指标。表观遗传时代，一种生物学反射 衰老的个体变异性具有明显的潜力作为预防PTB的有用参数 精确健康的观点。目前，预测PTB的能力很差，尤其是黑色 女性。 Precision Health有可能识别有PTB风险的单个女性，并且 确定治疗靶标，以防止个人患有PTB。