Human Exposure and Toxic Responses to Biomaterials

人体对生物材料的接触和毒性反应

• 批准号: 8399340
• 负责人: JONATHAN A DOORN
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399340
• 关键词: Address; American; Area; Award; Biocompatible Materials; Biology; Chemicals; Chemistry; DNA; Development; Disease; Education; Educational workshop; Engineering; Environment; Environmental Exposure; Environmental Health; Event; Exposure to; Feedback; Fostering; Funding; Future; Genomic Instability; Health; Human; Knowledge; Lesion; Link; Malignant Neoplasms; Medicine; Mission; Molecular; Mutation; Nanotechnology; National Institute of Environmental Health Sciences; Paper; Pharmaceutical Preparations; Philadelphia; Postdoctoral Fellow; Prevention; Process; Reactive Oxygen Species; Request for Applications; Research; Research Personnel; Role; Science; Scientist; Societies; Students; Toxic effect; Toxicology; Training; Travel; Work; base; design; environmental agent; exposed human population; interdisciplinary approach; interest; meetings; member; nanotoxicology; posters; professor; programs; repaired; response; structural biology; symposium; toxicant

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 244th National Meeting and Exposition in Philadelphia, PA from Sunday, August 19, 2012 to Wednesday, August 22, 2012. A unique feature of this ACS meeting is the broad theme of the entire meeting, "Materials for Health and Medicine", which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. The global theme "Materials for Health and Medicine" aligns closely with the core focus areas of the Division of Chemical Toxicology and thus provides a backdrop that reinforces programming in the Division and related content particularly for students and postdoctoral fellows. Three interrelated symposia are planned around the central theme "Human Exposure and Toxic Responses to Biomaterials" and include invited talks by a diverse group of leading established and up-and-coming scientists. The two symposia for which support is requested have especially strong relevance to the mission of the NIEHS. The first (Symposium #2) is entitled "Genome Instability" and addresses molecular mechanisms by which electrophiles and reactive oxygen species cause lesions and mutations to DNA and the resulting repair processes. The second (Symposium #3) is entitled "Harnessing Nanotechnology for Human Health and Environment" and focuses on the emerging field of nanotechnology and health implications for such engineered materials (i.e., nanotoxicology). A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote awards symposium and a professional development workshop. Overall, the ACS TOXI meeting is designed to disseminate current information regarding toxicants and disease and provide young scientists with a rich training environment. PUBLIC HEALTH RELEVANCE: Effective prevention and treatment of environmentally-related diseases require an understanding of underlying mechanisms that link environmental exposures to disease mechanisms. This meeting of the Division of Chemical Toxicology of the American Chemical Society will explore the chemical mechanisms for disease processes including cancer; specifically, the sponsored symposia will feature cutting edge research on the impact of biomaterials (nanotechnology and nanotoxicology), environmental agents, drugs and endogenous compounds on human health and disease.

描述（由申请人提供）：本申请请求支持美国化学会 (ACS) 化学毒理学部于 2012 年 8 月 19 日星期日至 8 月 22 日星期三在宾夕法尼亚州费城举行的第 244 届全国会议和博览会上的规划，2012 年。本次 ACS 会议的一个独特之处是整个会议的广泛主题“健康和医学材料”，它将所有 ACS 计划中的重点事件结合起来部门。 ACS 化学毒理学部的使命是促进对导致疾病过程以及环境因素、生物材料、药物和内源性化学物质毒性的化学机制的理解。该部门整合了化学、化学生物学、结构生物学、毒理学、环境健康科学和疾病机制方面的工作。全球主题“健康和医学材料”与化学毒理学部门的核心重点领域密切相关，从而提供了一个加强该部门规划和相关内容的背景，特别是针对学生和博士后研究员。围绕“人类暴露和对生物材料的毒性反应”的中心主题计划举办三场相互关联的研讨会，其中包括由不同领域的知名科学家和崭露头角的科学家邀请的演讲。请求支持的两个研讨会与 NIEHS 的使命尤其密切相关。第一场（研讨会#2）的标题是“基因组不稳定性”，讨论了亲电试剂和活性氧引起 DNA 损伤和突变以及由此产生的修复过程的分子机制。第二场（研讨会＃3）的标题是“利用纳米技术促进人类健康和环境”，重点关注纳米技术的新兴领域以及此类工程材料对健康的影响（即纳米毒理学）。提供的论文会议和青年研究者研讨会为年轻科学家提供了接受培训的机会，以展示他们的主要贡献并获得资深专家的重要反馈。其他亮点包括主题颁奖研讨会和专业发展研讨会。总体而言，ACS TOXI 会议旨在传播有关毒物和疾病的最新信息，并为年轻科学家提供丰富的培训环境。 公共卫生相关性：有效预防和治疗与环境相关的疾病需要了解将环境暴露与疾病机制联系起来的潜在机制。美国化学会化学毒理学部的这次会议将探讨包括癌症在内的疾病过程的化学机制；具体而言，主办的研讨会将重点研究生物材料（纳米技术和纳米毒理学）、环境因素、药物和内源性化合物对人类健康和疾病的影响。