CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 8361778
• 负责人: JONATHAN A DOORN
• 金额: $ 1.12万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361778
• 关键词: Biological Assay; Diagnostic; Event; Flow Cytometry; Funding; Grant; National Center for Research Resources; Noise; Phase; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Resolution; Resources; Signal Transduction; Sorting - Cell Movement; Source; Surface; System; United States National Institutes of Health; Work; cost; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 表面增强拉曼光谱 (SERS) 纳米颗粒具有独特的光谱带，可用于生物医学诊断。 特别是，SERS 颗粒已成为流式细胞术有前途的信标。 由于 SERS 颗粒具有独特的拉曼光谱和高信噪比，因此它们有可能用于多重分析，不仅需要大的动态范围，而且需要窄的光谱带宽来区分事件。 我们正在努力使用 LANL 开发的流式细胞术系统（包括光谱、相敏和高分辨率仪器）来表征 SERS 颗粒。