CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 7956797
• 负责人: JONATHAN A DOORN
• 金额: $ 1.61万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956797
• 关键词: Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Event; Flow Cytometry; Funding; Grant; Institution; Noise; Phase; Raman Spectrum Analysis; Research; Research Personnel; Resolution; Resources; Signal Transduction; Sorting - Cell Movement; Source; Spectrum Analysis; Surface; System; United States National Institutes of Health; Work; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 表面增强拉曼光谱 (SERS) 纳米颗粒具有独特的光谱带，可用于生物医学诊断。 特别是，SERS 颗粒已成为流式细胞术有前途的信标。 由于 SERS 颗粒具有独特的拉曼光谱和高信噪比，因此它们有可能用于多重分析，不仅需要大的动态范围，而且需要窄的光谱带宽来区分事件。 我们正在努力使用 LANL 开发的流式细胞术系统（包括光谱、相敏和高分辨率仪器）来表征 SERS 颗粒。