Genomics

基因组学

• 批准号: 10600154
• 负责人: Kevin Knudtson
• 金额: --
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-14 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600154
• 关键词: Alleles; Artificial Intelligence; Bioinformatics; Biological Assay; Blood; Cancer Center Support Grant; Cells; Chromium; Clinic; Clinical; Clinical Research; Cloud Computing; Communities; Complex; Comprehensive Cancer Center; Computer software; Consultations; Custom; DNA; DNA Microarray Chip; DNA Sequence; DNA sequencing; Data; Databases; Detection; Disease; Experimental Designs; Generations; Genes; Genome; Genomics; Genomics Shared Resource; Goals; Hour; Human Resources; Informatics; Laboratory Research; Liquid substance; Location; Machine Learning; Maintenance; Malignant Neoplasms; Molecular; Molecular Biology; Monitor; Nucleic Acids; Oligonucleotides; Pathology; Phase; Process; RNA; Repetitive Sequence; Research; Research Design; Research Personnel; Resource Sharing; Resources; Robot; Running; Sampling; Services; System; Techniques; Technology; Time; Tissue Sample; Tissues; Transcript; Update; Variant; Viral Vector; Work; base; bioinformatics tool; cloud storage; cost; data repository; design; digital; exome; exome sequencing; experimental study; genetic variant; genome analysis; genome sequencing; genomic data; improved; instrument; instrumentation; member; nanopore; new technology; next generation sequencing; programs; single cell analysis; single cell mRNA sequencing; single-cell RNA sequencing; therapeutic target; tool; transcriptome sequencing; transcriptomic profiling; transcriptomics; tumor heterogeneity; vector; whole genome

The Genomics Shared Resource (GSR) provides a broad spectrum of services and resources designed to make the state-of-the-art techniques used in DNA sequence and transcript analysis readily available to the Holden Comprehensive Cancer Center (HCCC) laboratory and clinical research communities. The researchbased services and resources of the GSR include: 1) DNA sequencing, including whole exome sequencing, 2) custom oligonucleotides, 3) DNA microarrays (Illumina BeadArray system), 4) real-time PCR, 5) molecular biology computing, and 6) genome, mRNA and single cell sequencing using next-generation sequencing (NGS) technologies. The GSR also provides access to state-of-the-art informatics including bioinformatics software and tools, public/local data and databases and computing and machine-learning/artificial intelligence capabilities. Molecular biology computing personnel work closely with investigators early in the process to improve study design and assure generation of high-quality data that meets the needs of the investigators. GSR also continues to evaluate and update services to remain cutting-edge and provide new services needed and serves HCCC investigators from each of the HCCC programs.

基因组共享资源（GSR）提供了广泛的服务和资源 使DNA序列和转录分析中使用的最新技术容易可用 霍顿综合癌症中心（HCCC）实验室和临床研究社区。 GSR的基于研究的服务和资源包括：1）DNA测序，包括整个外显子组测序，2） 定制寡核苷酸，3）DNA微阵列（Illumina Beadarray系统），4）实时PCR，5）分子 生物学计算以及6）基因组，mRNA和单细胞测序使用下一代测序 （NGS）技术。 GSR还提供了包括生物信息学在内的最先进信息学的访问 软件和工具，公共/本地数据和数据库以及计算以及机器学习/人工智能 功能。分子生物学计算人员在此过程的早期与研究人员紧密合作 改善研究设计并确保满足研究人员需求的高质量数据的生成。 GSR还继续评估和更新服务，以保持尖端并提供所需的新服务 并为每个HCCC计划的HCCC调查人员提供服务。