Research Training for Computation and Informatics in Biology and Medicine

生物学和医学计算和信息学研究培训

基本信息

批准号：
7625392
负责人：
GEORGE NEAL PHILLIPS
金额：
$ 2.68万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7625392
关键词：
Accounting Acquired Immunodeficiency Syndrome Address Adrenergic beta-Antagonists Adult Adverse reactions Advertising Advisory Committees Affect Affinity Algorithms Alleles Alzheimer&apos s Disease Amino Acid Sequence Amino Acids Anabolism Animal Model Animals Appointment Area Artificial Intelligence Arts Attention Award Back Bacteria Bacterial Genome Bacterial Physiology Bacteriology Bacteriophage T7 Bar Codes Behavior Benchmarking Binding Binding Sites Biochemical Biochemical Pathway Biochemical Reaction Biochemistry Bioinformatics Biological Biological Models Biological Preservation Biological Process Biological Sciences Biology Biomedical Engineering Biomedical Research Biometry Biophysics Bioremediations Bite Blood Books Businesses CS514 California Caring Case Study Catalysis Categories Cell Communication Cell Compartmentation Cells Characteristics Chemicals Chemistry Class Classification Clinic Clinical Clinical Data Clinical Informatics Collaborations Collection Color Commit Communicable Diseases Communication Communities Complement Complex Computational Biology Computational Science Computational algorithm Computer Graphics Computer Simulation Computer Systems Computer information processing Computer software Computerized Medical Record Computers Computing Methodologies Condition Conflict (Psychology)Count Credentialing Crystallography Cues DNA DNA Sequence Rearrangement Daphne plant Data Data Analyses Data Set Data Sources Database Management Systems Databases Decision Making Development Diffusion Digital Libraries Dimensions Discipline Discipline of Nursing Disease Disease susceptibility District of Columbia Docking Doctor of Philosophy Double Stranded RNA Virus Drug Formulations Ecology Economic Models Education Educational Background Educational Curriculum Educational process of instructing Effectiveness Electron Diffraction Microscopy Electronics Elements Engineering Ensure Environment Enzyme Kinetics Enzymes Epidemic Epidemiologic Studies Epidemiologist Equation Equilibrium Escherichia coli Ethics Etiology Eukaryota Eukaryotic Cell Event Exhibits Experimental Designs Expert Systems Exposure to Faculty Family Farming environment Feedback Fellowship Fingerprint Focal Infection Foundations Fourier Transform Funding Future Game Theory Gene Expression Gene Expression Regulation Generations Genes Genetic Genetic Databases Genetic Transcription Genome Genomics Genotype Geographic Locations Glaucoma Glycoproteins Goals Grant Graph Gray unit of radiation dose Growth Growth Factor HIV-1 Hand Health Health Information System Health Personnel Health Policy Health Services Accessibility Health system Healthcare Healthcare Systems Home environment Hormones Hot Spot Hour Housing Human Human Genetics Image Imagery Immersion Investigative Technique Improve Access Incentives Indium Individual Industry Infection Infectious Agent Influenza Informatics Information Systems Information Technology Institutes Institution Instruction Interdisciplinary Study Interferons Interview Joints Judgment Kinetics Knowledge Label Laboratories Language Lead Learning Least-Squares Analysis Left Letters Libraries Life Ligands Linear Programming Linear Regressions Link Lipids Literature Location Logic Long-Term Care Machine Learning Macromolecular Complexes Malignant Neoplasms Mammalian Orthoreovirus Mammography Maps Mathematics Measures Mediator of activation protein Medical Medical History Medical Informatics Medical Records Medicine Mentors Metabolic Pathway Metabolism Metals Methods Minor Minority Mission Modeling Modification Molecular Molecular Analysis Molecular Biology Molecular Machines Molecular Structure Monitor Motion Motivation Mutation Natural Language Processing Network-based Non-Insulin-Dependent Diabetes Mellitus None or Not Applicable North Carolina Numbers Nursing Schools Nutrient Object Class Occupations One-Step dentin bonding system Online Systems Operative Surgical Procedures Operon Organic Chemistry Organism Osteoporosis Outcome Palpitations Pan Genus Participant Pathway interactions Patients Pattern Peer Review Performance Personal Health Records Personal Satisfaction Persons Pharmaceutical Preparations Pharmacogenetics Phase Phenotype Physical Chemistry Physical environment Physics Physiology Plants Plasma Play Polymerase Population Population Genetics Positioning Attribute Postdoctoral Fellow Prevention Price Privacy Probability Problem Solving Process Production Productivity Program Evaluation Prokaryotic Cells Property Protein Biosynthesis Proteins Proteomics Provider Publications Published Comment Purpose Quality of life RNA RNA Caps RNA Phages Range Rate Reaction Reading Recommendation Records Recovery Recruitment Activity Regulation Regulator Genes Regulatory Element Type Regulatory Pathway Relative (related person)Relaxation Reovirus Reporting Representations, Knowledge (Computer)Research Research Institute Research Personnel Research Project Grants Research Proposals Research Training Resolution Resources Retinal Cone Review Committee Ribonucleases Ribosomal RNA Ribosomes Robotics Role Role playing therapy Rural Population Sampling Scanning School Nursing Schools Science Science of genetics Scientist Screening procedure Selection Criteria Self Management Semantics Sequence Alignment Sequence Analysis Series Severe Acute Respiratory Syndrome Shapes Side Signal Transduction Simulate Single Nucleotide Polymorphism Site Software Tools Solid Solutions Sorting - Cell Movement Source Specificity Standards of Weights and Measures Statistical Methods Structure Students Substance abuse problem Suggestion Supervision Surface Surveys System Systems Biology Taxes Techniques Technology Testing Text Thermodynamics Thinking Time Title Traineeship Training Training Programs Transcript Transcriptional Regulation Trees Triad Acrylic Resin Underrepresented Minority United States Universities Urination Variant Vertebral column Vesicular stomatitis Indiana virus Viral Virus Virus Assembly Vision Week Wisconsin Wood material Work Writing X-Ray Crystallography Yersinia pestis Yin Zip Code aluminum sulfate animation base biological research biomedical informatics carbon fixation career chemical kinetics cohort college comparative computer based statistical methods computer science computerized concept cost cryptography cytotoxic data mining data modeling data structure day density design drinking driving force electron density experience falls fitness frontier genetic epidemiology genome sequencing hormone biosynthesis hypertensive heart disease improved information organization insight intercellular communication interdisciplinary approach interest knowledge base lectures lipid transport macromolecule malignant breast neoplasm markov model mathematical model medical schools member membrane biogenesis metabolomics microbial molecular dynamics multidisciplinary network models next generation novel novel strategies nutrition patient home care patient privacy placental ribonuclease inhibitor post-doctoral training posters pre-doctoral predictive modeling professor programs promoter prospective protein folding protein structure radiologist receptor repository research and development research study response satisfaction scale up simulation skills small molecule social statistics systems research theories tool transcription factor translational medicine two-dimensional vector virus development virus resource

项目摘要

The Computation and Informatics in Biology and Medicine (CIBM) training program is helping to produce the next generation of researchers of biomedical problems with strengths in both informatics and biology. The interplay between computational and statistical methods in the biomedical sciences continues to expand rapidly so that now both computer modeling and informatics play key roles. Our faculty and trainees have been developing robust algorithms for the analysis of molecular data. Increasingly, questions in the biosciences are being phrased for these more quantitative approaches, and computer scientists are discovering new computational approaches in attempting to address biological problems. Furthermore, the power of new hardware, algorithms, and software is transforming our thinking about complex systems research. These advances are only possible when computer scientists understand enough about the problems to design usable tools and when bioscientists understand what is possible using computational and information technologies. CIBM has focused on the development of novel bioinformatics algorithms to analyze molecular data, including genome sequences, proteins (levels, interactions, structures), and regulatory pathways. We propose that for phase two of the program that we continue this focus and to further distinguish our program by adding a unique translational medicine component. In a collaboration with the Marshfield Clinic, our trainees will have the added opportunity to develop algorithms to predict clinical parameters, such as disease susceptibility or treatment response, from combined molecular and clinical data. A strong training program, including a multidisciplinary core curriculum has been developed at CIBM, and the environment at the University of Wisconsin in biology and computational sciences provides a rich setting for research training at the graduate and postdoctoral level.

生物学和医学（CIBM）培训计划的计算和信息学正在帮助生产下一代生物医学问题的研究人员在信息学和生物学中都具有优势。这生物医学科学中计算方法和统计方法之间的相互作用继续扩展迅速使现在的计算机建模和信息学都扮演关键角色。我们的教师和学员有正在开发可靠的算法来分析分子数据。越来越多的问题这些更定量的方法正在为生物科学所用，计算机科学家是在试图解决生物学问题时发现新的计算方法。此外，新硬件，算法和软件的力量正在改变我们对复杂系统的思考研究。只有当计算机科学家对设计可用工具以及生物科学家使用计算的问题和信息技术。 CIBM的重点是开发新型生物信息学算法，以分析分子数据，即包括基因组序列，蛋白质（水平，相互作用，结构）和调节途径。我们提出，对于计划的第二阶段，我们将继续这一重点并进一步区分我们的计划通过添加独特的转化医学组成部分。在与Marshfield诊所的合作中学员将有更多机会开发算法以预测临床参数，例如分子和临床数据的疾病敏感性或治疗反应。在CIBM开发了一个强大的培训计划，包括多学科核心课程，并威斯康星大学生物学和计算科学的环境提供了丰富的环境用于研究生和博士后一级的研究培训。