The Data, Evaluation, and Coordination Center (DECC) for Connecting Underrepresented Populations to Clinical Trials (CUSP2CT)

用于将代表性不足的人群与临床试验联系起来的数据、评估和协调中心 (DECC) (CUSP2CT)

• 批准号: 10597291
• 负责人: HONGFANG LIU
• 金额: $ 55.44万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597291
• 关键词: Adopted; Affect; Award; Benchmarking; Clinical Data; Clinical Trials; Clinical Trials Network; Collaborations; Common Data Element; Communication; Communities; Consensus; Data; Data Analytics; Data Collection; Data Pooling; Data Science; Department of Defense; Development; Discipline; Education and Outreach; Educational Intervention; Ethics; Evaluation; Fostering; Generations; Goals; Grant; Health; Human; Incidence; Infrastructure; Intervention; Leadership; Learning; Logistics; Malignant Neoplasms; Manuscripts; Measures; Methods; Mission; National Center for Advancing Translational Sciences; Oncology; Outcome; Policies; Population; Positioning Attribute; Procedures; Process; Program Evaluation; Protocols documentation; Publications; Recommendation; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Support; Resources; Science; Secure; Services; Site; Standardization; Structure; Terminology; Underrepresented Populations; Work; base; black men; cancer care; cancer health disparity; data exchange; data harmonization; data management; data sharing; evidence base; health disparity; health equity; implementation strategy; interoperability; meetings; member; mortality; operation; privacy preservation; programs; social media; statistics; tool; web portal

Project Summary Despite the decline in overall mortality and incidence of cancer in the US population, disparities in cancer care still largely exist within certain groups. One key barrier causing the lack of proportional representation of these groups is the lack of dedicated efforts employing scientific rigorous approaches and implementation strategies for increasing their proportional representation in clinical trials. The Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) program aims to implement and evaluate multilevel and culturally tailored outreach and education interventions that will increase the accrual of underrepresented populations in clinical trials. To support the CUSP2CT program, we are proposing to be the Data, Evaluation, and Coordination Center (DECC) to support the data and evaluation activities and coordinate a learning collaborative towards mitigating the key barriers of cancer disparity. Specifically, we will collaborate with the CUSP2CT U01 investigators and interact with involved NCI staff members and with other stakeholders, as needed, to carry out the following activities: 1) establish effective and efficient administrative processes and infrastructure through scientific leadership, organizational processes, governance structure, effective oversight and operational procedures to achieve optimal communication, collaboration, coordination, and dissemination of the CUSP2CT research, 2) facilitate and coordinate data collection and management across the CUSP2CT program to facilitate evidence generation and rapid dissemination of methods and tools, 3) organize and facilitate collaborative efforts on program evaluation, engagement, and communication, and 4) foster a learning collaborative in leading and coordinating trans-CUSP2CT research. We are uniquely positioned to be the DECC for CUSP2T leveraging strong track record in: (i) implementing health equity centers and consortia (e.g. Dr. Odedina is MPI on NCI CRCHD U54 CaRE2 Health Equity Center and contact MPI for a newly awarded Department of Defense iCCaRE for Black Men Consortium); (ii) leading statistics and data management coordinating center effort in cancer trials (e.g., Mayo is the Statistics and Data Management Center of the Alliance for Clinical Trials in Oncology (Alliance) including both interventional and NCORP grants); (ii) leading standardization and interoperability for practice and research (e.g., Mayo has been contributing to the NCI Terminology Service Development Effort and part of the data harmonization efforts in the NCATS Clinical Data to Health (CD2H)). Additionally, we have strong institutional priorities aligning with CUSP2CT with existing infrastructure and resources supporting the CUSP2CT mission.

项目概要 尽管美国人口的总体死亡率和癌症发病率有所下降，但癌症治疗方面的差异 仍然主要存在于某些群体中。导致这些群体缺乏比例代表性的一个关键障碍 群体缺乏采用科学严谨的方法和实施策略的专门努力 以增加他们在临床试验中的比例代表性。连接代表性不足的人群 临床试验 (CUSP2CT) 计划旨在实施和评估多层次和文化定制的推广 教育干预措施将增加临床试验中代表性不足的人群的应计人数。到 支持 CUSP2CT 计划，我们提议成为数据、评估和协调中心（DECC） 支持数据和评估活动并协调学习协作以减轻关键 癌症差异的障碍。具体来说，我们将与 CUSP2CT U01 研究人员合作并互动 根据需要与 NCI 相关工作人员和其他利益相关者一起开展以下活动：1) 通过科学领导建立有效和高效的行政流程和基础设施， 组织流程、治理结构、有效监督和操作程序以实现 CUSP2CT 研究的最佳沟通、协作、协调和传播，2) 促进 协调整个 CUSP2CT 计划的数据收集和管理，以促进证据生成 以及快速传播方法和工具，3) 组织和促进项目上的协作努力 评估、参与和沟通，4) 促进领导和协调方面的学习协作 跨 CUSP2CT 研究。 我们凭借在以下方面的良好记录，成为 CUSP2T 的 DECC：(i) 实施 健康公平中心和联盟（例如 Odedina 博士是 NCI CRCHD U54 CaRE2 健康公平中心的 MPI 并联系 MPI 获取新授予的国防部 iCCaRE for Black Men Consortium）； (二) 领导 统计和数据管理协调中心在癌症试验方面的工作（例如，梅奥是统计和数据中心 肿瘤学临床试验联盟（联盟）管理中心，包括介入和 NCORP 赠款）； (ii) 领先的实践和研究标准化和互操作性（例如，Mayo 已 为 NCI 术语服务开发工作以及部分数据协调工作做出贡献 NCATS 健康临床数据 (CD2H))。此外，我们有强有力的机构优先事项 CUSP2CT 拥有支持 CUSP2CT 任务的现有基础设施和资源。