The Data, Evaluation, and Coordination Center (DECC) for Connecting Underrepresented Populations to Clinical Trials (CUSP2CT)

用于将代表性不足的人群与临床试验联系起来的数据、评估和协调中心 (DECC) (CUSP2CT)

• 批准号: 10597291
• 负责人: HONGFANG LIU
• 金额: $ 55.44万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597291
• 关键词: Adopted; Affect; Award; Benchmarking; Clinical Data; Clinical Trials; Clinical Trials Network; Collaborations; Common Data Element; Communication; Communities; Consensus; Data; Data Analytics; Data Collection; Data Pooling; Data Science; Department of Defense; Development; Discipline; Education and Outreach; Educational Intervention; Ethics; Evaluation; Fostering; Generations; Goals; Grant; Health; Human; Incidence; Infrastructure; Intervention; Leadership; Learning; Logistics; Malignant Neoplasms; Manuscripts; Measures; Methods; Mission; National Center for Advancing Translational Sciences; Oncology; Outcome; Policies; Population; Positioning Attribute; Procedures; Process; Program Evaluation; Protocols documentation; Publications; Recommendation; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Support; Resources; Science; Secure; Services; Site; Standardization; Structure; Terminology; Underrepresented Populations; Work; base; black men; cancer care; cancer health disparity; data exchange; data harmonization; data management; data sharing; evidence base; health disparity; health equity; implementation strategy; interoperability; meetings; member; mortality; operation; privacy preservation; programs; social media; statistics; tool; web portal

Project Summary Despite the decline in overall mortality and incidence of cancer in the US population, disparities in cancer care still largely exist within certain groups. One key barrier causing the lack of proportional representation of these groups is the lack of dedicated efforts employing scientific rigorous approaches and implementation strategies for increasing their proportional representation in clinical trials. The Connecting Underrepresented Populations to Clinical Trials (CUSP2CT) program aims to implement and evaluate multilevel and culturally tailored outreach and education interventions that will increase the accrual of underrepresented populations in clinical trials. To support the CUSP2CT program, we are proposing to be the Data, Evaluation, and Coordination Center (DECC) to support the data and evaluation activities and coordinate a learning collaborative towards mitigating the key barriers of cancer disparity. Specifically, we will collaborate with the CUSP2CT U01 investigators and interact with involved NCI staff members and with other stakeholders, as needed, to carry out the following activities: 1) establish effective and efficient administrative processes and infrastructure through scientific leadership, organizational processes, governance structure, effective oversight and operational procedures to achieve optimal communication, collaboration, coordination, and dissemination of the CUSP2CT research, 2) facilitate and coordinate data collection and management across the CUSP2CT program to facilitate evidence generation and rapid dissemination of methods and tools, 3) organize and facilitate collaborative efforts on program evaluation, engagement, and communication, and 4) foster a learning collaborative in leading and coordinating trans-CUSP2CT research. We are uniquely positioned to be the DECC for CUSP2T leveraging strong track record in: (i) implementing health equity centers and consortia (e.g. Dr. Odedina is MPI on NCI CRCHD U54 CaRE2 Health Equity Center and contact MPI for a newly awarded Department of Defense iCCaRE for Black Men Consortium); (ii) leading statistics and data management coordinating center effort in cancer trials (e.g., Mayo is the Statistics and Data Management Center of the Alliance for Clinical Trials in Oncology (Alliance) including both interventional and NCORP grants); (ii) leading standardization and interoperability for practice and research (e.g., Mayo has been contributing to the NCI Terminology Service Development Effort and part of the data harmonization efforts in the NCATS Clinical Data to Health (CD2H)). Additionally, we have strong institutional priorities aligning with CUSP2CT with existing infrastructure and resources supporting the CUSP2CT mission.

项目摘要 尽管美国人口中癌症的总死亡率和癌症的发病率下降，但癌症护理的差异 在某些群体中仍然存在很大程度上。导致缺乏比例表示这些的一个关键障碍 小组是使用科学严格的方法和实施策略缺乏专门的努力 在临床试验中增加其比例表示。连接不足的人群 临床试验（CUSP2CT）计划旨在实施和评估多层次和文化量身定制的外展 和教育干预措施将增加临床试验中代表性不足人群的应计。到 支持CUSP2CT计划，我们建议作为数据，评估和协调中心（DECC） 支持数据和评估活动，并协调学习协作以减轻关键 癌症差异的障碍。具体而言，我们将与cusp2ct U01调查人员合作并进行互动 与参与的NCI工作人员以及其他利益相关者一起进行以下活动：1） 通过科学领导来建立有效，有效的行政流程和基础设施， 组织过程，治理结构，有效的监督和运营程序以实现 最佳沟通，协作，协调和浪尖研究的传播，2）促进 并协调cusp2CT计划的数据收集和管理，以促进证据生成 以及方法和工具的快速传播，3）组织和促进计划的协作努力 评估，参与和沟通，以及4）在领导和协调方面促进学习协作 反式CUSP2CT研究。 我们独特地成为cusp2t的DECC，利用强大的往绩记录：（i）实施 卫生平等中心和财团（例如，ODEDINA博士是NCI CRCHD U54 CARE2健康权益中心的MPI 并联系MPI，以获得新授予的黑人国防部国防部ICCARE）； （ii）领导 统计和数据管理协调癌症试验中心的工作（例如，梅奥是统计和数据 肿瘤学临床试验联盟管理中心（联盟）包括介入和 NCORP赠款）； （ii）领导标准化和实践和研究的互操作性（例如，梅奥一直是 为NCI术语服务开发工作做出贡献，以及数据协调工作的一部分 NCATS健康数据（CD2H））。此外，我们有强大的机构优先事项与 cusp2ct具有支持cusp2ct任务的现有基础架构和资源。