Motion-robust brain MRI for infants

适用于婴儿的运动鲁棒性脑 MRI

• 批准号: 10264551
• 负责人: Todd William Deckard
• 金额: $ 182.22万
• 依托单位: TURING MEDICAL TECHNOLOGIES INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-03 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10264551
• 关键词: 2 year old; 3 year old; Address; Anesthesia procedures; Award; Benchmarking; Brain; Brain Injuries; Brain imaging; Caring; Child; Clinic; Clinical; Computer software; Data; Data Display; Devices; Diagnostic; Digital Imaging and Communications in Medicine; Ensure; Entropy; Face; Functional Magnetic Resonance Imaging; Funding; Goals; Head; Health; Human; Image; Infant; Institution; Investigation; Kinetics; MRI Scans; Magnetic Resonance Imaging; Medical; Monitor; Motion; Movement; Patients; Phase; Physicians; Predisposition; Process; Radiation; Randomized; Research; Resolution; Risk; Robin bird; Running; Sampling; Scanning; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Speed; Structure; System; Technology; Temperature; Testing; Time; Update; Vendor; Work; aged; base; cost; data acquisition; design; functional MRI scan; high resolution imaging; improved; infant monitoring; neonate; reconstruction; tool; usability; wasting

Project Abstract/Summary The objective of this SBIR/STTR Fast Track submission is to provide a software solution to reduce the effects of head motion during brain MRIs of infants. Because structural MRI scanning produces high-resolution images and does not expose patients to radiation, it has become an immensely valuable diagnostic tool, particularly for imaging the brain in infant samples. Approximately $20 billion worth of brain MRIs are performed each year in the US, including 500,000 infant scans. The greatest problem for MRI is its susceptibility to patient motion. About 20% of clinical brain MRIs are distorted by motion – wasting ~$4 billion/year. Currently, MRI motion is dealt with by repeating scans or anesthesia. Both approaches diminish throughput, while increasing costs, patient burden, and health risks. In infants, anesthesia causes brain injury, leading to an FDA blackbox warning against it for children under 3 years old. Thus, the standard of brain MRI care in infants is swaddling them and hoping for the best. There are no infant-compatible MRI motion monitoring systems, despite the great need. Camera-based systems encounter critical limitations when used with infants – only FIRMM's software-only approach can work easily and reliably. Two obstacles must be overcome with support from this SBIR/STTR award to develop FIRMM-infant for research and clinical use. 1) Infant-compatible versions of motion-sensing/correcting sequences must be generated (T1w, T2w). 2) FIRMM-infant usability and its ability to improve MRI quality must be demonstrated. The proposed research focuses on delivering proof-of-concept for FIRMM-infant (Phase I) and building and validating a clinical-ready version of FIRMM-infant across vendors (Phase II). The FIRMM-infant device provides scan operators and physicians with real time motion information, and in combination with vNav ready motion sensing sequences will MR scans safer, faster, and less expensive for infant imaging.

项目摘要/总结 本次 SBIR/STTR 快速通道提交的目的是提供一个软件解决方案来减少影响 因为结构 MRI 扫描会产生高分辨率图像。 并且不会使患者受到辐射，它已成为一种非常有价值的诊断工具，特别是对于 每年对婴儿样本进行脑部 MRI 成像的费用约为 200 亿美元。 美国，包括 500,000 次婴儿扫描，MRI 的最大问题是它对患者运动的敏感性。 大约 20% 的临床脑部 MRI 因运动而扭曲——目前，MRI 运动每年浪费约 40 亿美元。 通过重复扫描或麻醉来处理，这两种方法都会降低吞吐量，同时增加成本。 患者负担和健康风险 在婴儿中，麻醉会导致脑损伤，从而导致 FDA 黑匣子。 警告 3 岁以下儿童不要使用因此，婴儿脑部 MRI 护理的标准是襁褓。 他们并希望得到最好的结果。 尽管基于摄像头的需求很大，但目前还没有适合婴儿的 MRI 运动监测系统。 系统在与婴儿一起使用时遇到严重限制 - 只有 FIRMM 的纯软件方法才有效 必须在 SBIR/STTR 奖项的支持下轻松可靠地克服两个障碍才能进行开发。 FIRMM-婴儿用于研究和临床使用 1) 婴儿兼容版本的运动感应/校正。 必须生成序列（T1w、T2w）2) FIRMM-婴儿可用性及其提高 MRI 质量的能力。 必须证明。 拟议的研究重点是提供 FIRMM 婴儿（第一阶段）的概念验证以及构建和 跨供应商验证 FIRMM-infant 的临床就绪版本（第二阶段）。 为扫描操作员和医生提供实时运动信息，并与 vNav 结合使用 运动传感序列将使 MR 扫描更安全、更快，并且对于婴儿成像来说更便宜。