Core C: Data Management and Statistical Core

核心C：数据管理与统计核心

• 批准号: 10264625
• 负责人: JONATHAN D MAHNKEN
• 金额: $ 31.2万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264625
• 关键词: Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Bioinformatics; Biometry; Clinical; Collaborations; Communities; Consensus; Consult; Data; Data Analyses; Data Collection; Data Science; Databases; Development; Environment; Faculty; Funding; Future Generations; Grant; Informatics; Information Systems; Institution; Investigation; Kansas; Leadership; Management Information Systems; Manuscripts; Measures; Methodology; Methods; Michigan; Modification; Monitor; Neurodegenerative Disorders; Online Systems; Phase; Preparation; Publications; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Scientist; Services; Statistical Data Interpretation; System; Time; Training; Translations; Universities; Visualization; base; cohort; data exchange; data management; data resource; data science resource; design; distributed data; education research; electronic data; experience; falls; imaging study; improved; information processing; meetings; neuroimaging; novel; novel strategies; operation; outreach; programs; recruit; sound; success; tool; user-friendly

ABSTRACT: DATA MANAGEMENT AND STATISTICAL CORE The Data Management and Statistical (DMS) Core (Core C) supports the University of Kansas Alzheimer's Disease Research Center (KU ADRC). DMS Core faculty and staff have the training and experience to support the research needs of investigators that utilize KU ADRC resources. The central focus of this core is managing and maintaining the entire spectrum of study-related information for the Clinical Cohort that is collected across the cores and research projects. To support this objective a REDCap web-based data capture platform is utilized. Data are prepared for extraction by investigators and NACC, as well as provide statistical, bioinformatics, and data science expertise for research using the center. To support AD research the DMS Core has the following specific aims. Aim 1: Integrate, develop, and disseminate data and information management systems consistent with the evolving needs of AD research Aim 1a: Provide platforms for data capture, integration, and visualization for core-to-core integration Aim 1b: Efficiently integrate, organize, curate, and disseminate research data Aim 2: Enhance the quality of AD and aging research by providing investigators with statistical, `omics, and data science expertise Aim 2a: Support study design, oversight, and data analyses Aim 2b: Collaborate and consult in the preparation of study presentations and publications Aim 2c: Develop novel quantitative and data science methodologies to improve inference The DMS Core remains highly integrated across the cores. Data management, data extracts, and statistical support are provided, and the DMS Core has key roles as liaisons for core-to-core and core-to-research project interactions. The Core also supports the development and applications of tools and expertise for biostatistics, bioinformatics, and data science needs of AD research.

摘要：数据管理和统计核心 数据管理和统计（DMS）核心（核心C）支持堪萨斯大学阿尔茨海默氏症 疾病研究中心（KU ADRC）。 DMS核心教职员工都有培训和经验 支持利用KU ADRC资源的研究人员的研究需求。这个核心的主要重点是 管理和维护临床队列的整个研究相关信息的全部范围 跨核心和研究项目收集。为了支持此目标一个基于REDCAP Web的数据 使用捕获平台。准备数据由研究人员和NACC提取，并提供 统计，生物信息学和数据科学专业知识，用于研究中心。支持广告研究 DMS核心具有以下特定目标。 目标1：集成，开发和传播数据和信息管理系统 广告研究的不断发展需求 AIM 1A：为核心积分提供数据捕获，集成和可视化的平台 AIM 1B：有效整合，组织，策划和传播研究数据 目标2：通过为研究人员提供统计人员，提高AD和老化研究的质量 `OMICS和数据科学专业知识 AIM 2A：支持研究设计，监督和数据分析 AIM 2B：在准备研究演讲和出版物的准备工作中协作和咨询 AIM 2C：开发新颖的定量和数据科学方法来改善推理 DMS核心在整个核心之间保持高度集成。数据管理，数据提取和统计 提供了支持，并且DMS核心在核心对核心和核心研究项目的联络中具有关键角色 互动。核心还支持工具和专业知识的生物统计学的开发和应用， AD研究的生物信息学和数据科学需求。