Core C: Data Management and Statistical Core

核心C：数据管理与统计核心

基本信息

批准号：
9978594
负责人：
JONATHAN D MAHNKEN
金额：
$ 28.77万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9978594
关键词：
Adherence Aging Alzheimer&apos s Disease Alzheimer&apos s Disease Core Center Bioinformatics Biometry Clinical Clinical Data Collaborations Communities Computer software Data Data Analyses Data Analytics Data Collection Data Files Data Management Resources Databases Development Ensure Faculty Freezing Funding Genomics Human Resources Informatics Internal Medicine Investigation Kansas Leadership Literature Management Information Systems Manuscripts Measures Medical Informatics Metabolism Metadata Methodology Mitochondria Monitor Names Neurodegenerative Disorders Online Systems Phase Phenotype Pilot Projects Play Preparation Process Protocols documentation Publications Publishing Records Reporting Reproducibility Research Research Design Research Personnel Research Project Grants Research Support Resources Sampling Services Statistical Data Interpretation Support System System Time Training Translations Universities Update cohort data dictionary data dissemination data management data quality design distributed data electronic data experience neuroimaging novel operation programs repository research study sound statistics success user-friendly

Adherence Aging Alzheimer&apos s Disease Alzheimer&apos s Disease Core Center Bioinformatics Biometry Clinical Clinical Data Collaborations Communities Computer software Data Data Analyses Data Analytics Data Collection Data Files Data Management Resources Databases Development Ensure Faculty Freezing Funding Genomics Human Resources Informatics Internal Medicine Investigation Kansas Leadership Literature Management Information Systems Manuscripts Measures Medical Informatics Metabolism Metadata Methodology Mitochondria Monitor Names Neurodegenerative Disorders Online Systems Phase Phenotype Pilot Projects Play Preparation Process Protocols documentation Publications Publishing Records Reporting Reproducibility Research Research Design Research Personnel Research Project Grants Research Support Resources Sampling Services Statistical Data Interpretation Support System System Time Training Translations Universities Update cohort data dictionary data dissemination data management data quality design distributed data electronic data experience neuroimaging novel operation programs repository research study sound statistics success user-friendly

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项目摘要

ABSTRACT: DATA MANAGEMENT AND STATISTICS (DMS) CORE The Data Management and Statistics (DMS) Core (Core C) supports The University of Kansas Alzheimer’s Disease Center (KU ADC). Our personnel are faculty and staff from the Department of Biostatistics and from the Division of Medical Informatics within the Department of Internal Medicine. DMS Core faculty and staff have the training and experience to support the research needs of investigators that utilize KU ADC resources. The central focus of this core is managing and maintaining the entire spectrum of study-related information for the Clinical Cohort that is collected across the cores and research projects. To support this objective, the DMS core created and maintains a REDCap web-based data capture platform. DMS Core staff prepares data extracts for investigators and NACC and provide statistical, informatics, and bioinformatics expertise for research using the KU ADC. AD research is supported by the DMS Core under the following specific aims. Aim 1: Maintain data and information management systems and adapt to the KU ADC’s evolving needs. The DMS Core continually develops and supports the systems needed by the various core and projects. Data capture forms are built for research projects. Data from the Clinical Cohort are efficiently uploaded to the coordinating center (NACC). Aim 2: Enhance the quality of AD and aging research by providing investigators with statistical and bioinformatics expertise. The DMS Core aids investigators in designing their research studies and provides statistical oversight and analytic support. This support includes active participation in preparing research presentations and publications to ensure proper interpretations of findings. We also develop novel statistical methodology to enhance interpretations of experimental and observational data collected for AD research. The DMS Core remains highly integrated across the cores. The DMS Core provides data management, data extracts, and statistical support and plays a key role as a liaison for core-to-core and core-to-research project interactions. The Core also supports the development, informatics, statistical, and bioinformatics needs of KU ADC pilot projects.

摘要：数据管理和统计（DMS）核心数据管理和统计（DMS）核心（核心C）支持堪萨斯大学阿尔茨海默氏症疾病中心（KU ADC）。我们的人员是生物统计学系的教职员工，来自内科部门内的医学信息学部门。 DMS核心教职员工拥有培训和经验，以支持利用KU ADC资源的研究人员的研究需求。该核心的主要重点是管理和维护整个与研究相关的信息跨核心和研究项目收集的临床队列。为了支持这一目标，DMS CORE创建并维护一个基于RedCap Web的数据捕获平台。 DMS核心人员准备数据研究人员和NACC的摘录，并为统计，信息和生物信息学专业知识提供使用KU ADC的研究。 DMS核心在以下特定目标下得到了AD研究。目标1：维护数据和信息管理系统，并适应KU ADC不断发展的需求。 DMS核心不断开发并支持各种核心和项目所需的系统。数据捕获表是为研究项目而建立的。来自临床队列的数据有效地上传到协调中心（NACC）。目标2：通过为研究人员提供统计和生物信息学专业知识。 DMS核心帮助研究人员设计其研究并提供统计监督和分析支持。这种支持包括积极参与准备研究演讲和出版物，以确保对发现的正确解释。我们还发展了新颖的统计增强对AD研究收集的实验和观察数据的解释的方法。 DMS核心在整个核心之间保持高度集成。 DMS核心提供数据管理，数据提取，统计支持，并在核心对核心和核心研究的联络中发挥关键作用项目互动。核心还支持开发，信息，统计和生物信息学需求 KU ADC试点项目。