Administrative Core

行政核心

• 批准号: 10264661
• 负责人: Charles DeCarli
• 金额: $ 53.25万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264661
• 关键词: Address; Adherence; Advisory Committees; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Animal Welfare; Annual Reports; Award; Behavioral Research; Biological Markers; Caregiver research; Caring; Clinical; Cognitive; Cognitive aging; Collaborations; Communities; Data; Data Set; Dementia; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Environment; Epidemiology; Faculty; Funding; Funding Agency; Future; Geography; Goals; Grant; Growth; Heterogeneity; Image; Infrastructure; International; Leadership; Longevity; Minority Groups; Mission; Outcome; Participant; Pathology; Policies; Population Heterogeneity; Process; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Sampling; Science; Scientist; Serum; Strategic Planning; Time; Training; Training Programs; United States National Institutes of Health; Vision; Work; aging brain; caregiving; collaborative environment; community based research; complement resource; data exchange; ethnic minority population; flexibility; high risk; human subject; improved; innovation; next generation; novel; outreach; prevent; programs; racial minority; recruit; study population; success; therapy development; treatment strategy; undergraduate student

PROJECT SUMMARY/ABSTRACT - Administrative Core The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging while caring for those affected by dementia. To accomplish this mission, we have created a highly integrated and collaborative environment with extensive resources to support studies on the heterogeneity of cognitive aging and progression to dementia among diverse populations. The Administrative Core (AC) supports this mission through overall direction and optimal utilization of center resources with emphasis on strategies that encompass 1) development of new research initiatives, 2) leveraging available resources through integration of research effort and pursuit of research funding, 3) program growth through local, national and international collaborations and initiation of new programs, and, finally, 4) pursuit of funding sources for training of junior scientists so as to expand and provide continuity for our program of research on aging and ADRD. Our approach addresses a number of milestones set by the National Alzheimer’s Project Act by 1) evaluating disparities among ethnic and racial minority populations that are at higher risk for AD to mitigate risk and improve cognitive outcomes, 2) fully characterizing mixed pathologies and identifying unique risk factors,3) accelerating the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease (AD), 4) improving early diagnosis through discovery of novel imaging and serum biomarkers, 5) developing novel dementia treatment strategies, and 6) supporting caregiving through funded caregiver research. The AC also has a long tradition of supporting the overall NIA ADC Network to achieve NAPA goals “…through increasing flexibility and collaboration by leveraging resources, capabilities and research participants across the network”. Consistent with our overall approach, the AC also has historically contributed to efforts to “…unify goals, ensure that resources are most efficiently utilized, and is suitably flexible to facilitate the ability of the ADC network to respond to a dynamic scientific environment while incorporating the needs of all stakeholders…” As such, the AC provides outstanding leadership along with the infrastructure and the administrative support needed to meld the various Cores and geographically dispersed units of the UCD ADRC into a true, coherent and effective research center. Specifically, the AC will direct and strategically plan to utilize the full complement of resources and expertise of the UCD ADRC, incorporating the developmental projects, our community based research approach and extensive research training program to fulfill the milestones of NAPA.

项目摘要/摘要 - 行政核心 加州大学戴维斯分校阿尔茨海默氏病研究中心（UCD ADRC）的任务是推进科学 健康的大脑衰老，同时为受痴呆症影响的人携带。为了完成这项任务，我们有 创建了一个高度融合和协作的环境，并通过广泛的资源来支持研究 关于潜水人群中认知衰老和痴呆症的进展的异质性。 行政核心（AC）通过总体方向和最佳利用来支持这一任务 重点关注涵盖策略的资源1）开发新研究计划，2） 通过整合研究工作和追求研究资金来利用可用的资源，3） 通过本地，国家和国际合作以及新计划的倡议的计划增长，以及 最后，4）追求培训初级科学家的资金来源，以扩大和提供连续性 我们关于衰老和ADRD的研究计划。我们的方法解决了许多由 国家阿尔茨海默氏症的项目法案1）评估种族和种族少数民族之间的差异 降低风险和改善认知结果的AD风险较高，2）完全表征混合 病理和确定独特的危险因素，3）加速治疗的发展 预防，停止或扭转阿尔茨海默氏病（AD），4）通过 发现新型成像和血清生物标志物，5）制定新型痴呆疗法治疗策略，6） 通过资助的护理研究来支持护理。 AC还具有支持 总体NIA ADC网络实现NAPA目标“……通过提高灵活性和协作 利用整个网络的资源，能力和研究参与者”。与我们的整体一致 AC在历史上也有助于“……统一目标，确保资源最多 有效利用，并且适当灵活以促进ADC网络对动态的反应能力 科学环境在整合所有利益相关者的需求时……” AC提供 杰出的领导力以及融合各种的基础设施和所需的行政支持 UCD ADRC的核心和地理分散的单位成真，连贯和有效的研究 中心。具体而言，AC将指导和战略计划利用资源的完整完成和 UCD ADRC的专业知识，结合了发展项目，我们的基于社区的研究 方法和广泛的研究培训计划，以实现纳帕的里程碑。