Neuroimaging Core

神经影像核心

• 批准号: 10666453
• 负责人: Charles DeCarli
• 金额: $ 20.75万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666453
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Archives; Autopsy; Back; Biological Markers; Biomedical Engineering; Brain; Brain Injuries; Brain imaging; Clinical; Cognition; Cognitive; Collaborations; Communities; Complement; Computer Systems; Computer software; Country; Data; Data Analyses; Databases; Dementia; Diagnostic; Dimensions; Disease; Education; Faculty; Framingham Heart Study; Funding; Goals; Grant; Human; Image; Institution; International; Intuition; Life; Link; Longevity; Longitudinal Studies; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Measurement; Measures; Medical center; Methods; Mission; Nuclear Pore Complex; Play; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Privatization; Process; Quality Control; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Scanning; Scientist; Secure; Services; Structure; Students; System; Techniques; Tracer; Training; Vascular Diseases; Work; aging brain; cognitive change; cohort; computerized data processing; data management; education research; experience; faculty mentor; image processing; imaging biomarker; improved; investigator training; kinetic model; method development; neuroimaging; neuropathology; normal aging; novel; outreach; recruit; research clinical testing; statistics; success; usability

PROJECT SUMMARY: Neuroimaging Core The Neuroimaging Core (NC) plays an integral role in the UC Davis (UCD) ADRC scientific mission by providing imaging-based structural and functional markers of aging and disease processes. These imaging biomarkers support the primary aim of the UCD ADRC to understand factors that influence cognitive trajectories from normal aging to dementia. Building on nearly 15 years of success, the NC will continue to provide services related to acquisition, storage, post-processing and dissemination of imaging data. In addition, the NC will collaborate with other departments at UC Davis as well as other institutions to develop novel state- of-the-art methods for measuring the lifespan course of brain injury leading to dementia. The Aims of the NC reflect the steady progression of its capabilities. The NC is now a mature component of the ADRC that enriches the other Cores and the AD research community. It currently provides raw images to the Clinical and Neuropathology Cores to support diagnostic activities. The NC also provides validated state-of- the-art measurements of brain structure and function to the Data Management and Statistics Core and other collaborating centers to support research projects. Finally, the NC works with the Research Education Component and the Outreach Recruitment and Education Core to train investigators in neuroimaging methods and disseminate information regarding imaging related research. The addition of Dr. Audrey Fan to the NC brings a new dimension of expertise in the use of MRI and PET imaging for new biomarkers of vascular disease, aging and cognitive change. In addition to imaging acquisition expertise, she provides a strong link to the Biomedical Engineering Department at UC Davis and to new facilities such as the total-body EXPLORER PET scanner. The novel imaging strategies and kinetic modeling approaches from Dr. Fan’s lab complement existing NC research capabilities. With over 20 grants, including SCAN, currently supporting image acquisitions and processing by the NC, we provide benefits national and international collaborations that are far beyond the level of Core funding. The overall goals of the NC to image brain injury leading to dementia aligns with the National Alzheimer’s Project Act (NAPA) mission to identify pre-symptomatic AD, establishing early imaging biomarkers through large public-private studies such as ADNI. The goals of NC are to continue to provide essential resources to the UCD ADRC and build new capabilities at the forefront of neuroimaging.

项目摘要：神经影像核心 神经影像学核心（NC）在UC Davis（UCD）ADRC科学任务中扮演不可或缺的角色 提供基于成像的衰老和疾病过程的结构和功能标记。这些成像 生物标志物支持UCD ADRC的主要目的，以了解影响认知的因素 从正常衰老到痴呆症的轨迹。在近15年的成功基础上，北卡罗来纳州将继续 提供与成像数据的获取，存储，后处理和传播有关的服务。此外， NC将与加州大学戴维斯分校的其他部门以及其他机构合作，以开发新颖的国家 - 测量导致痴呆症的脑损伤寿命过程的ART方法。 NC的目的反映了其能力的稳定发展。 NC现在是 丰富其他核心和广告研究界的ADRC。它目前为原始图像提供 临床和神经病理学核心支持诊断活动。 NC还提供了经过验证的最新 对数据管理和统计核心以及其他的大脑结构和功能的测量 协作中心支持研究项目。最后，NC与研究教育合作 组成部分以及外展招聘和教育核心，以培训调查人员的神经影像学方法 并传播有关成像相关研究的信息。 Audrey博士在NC中加入了新的专业知识，在MRI和PET的使用方面具有新的专业知识 成像血管疾病，衰老和认知变化的新生物标志物。除了成像采集 她的专业知识，她提供了与加州大学戴维斯分校生物医学工程部门的牢固联系和新的 总体探险家PET扫描仪等设施。新颖的成像策略和动力学建模 FAN博士实验室完成现有NC研究功能的方法。 拥有20多个赠款，包括扫描，目前支持图像采集和北卡罗来纳州的处理，我们 提供远远超出核心资金水平的国家和国际合作福利。 北卡罗来纳州北卡罗来纳州的总体目标，以使脑损伤导致痴呆症与国家阿尔茨海默氏症的项目保持一致 ACT（NAPA）的使命识别症状前AD，通过大型生物标志物建立早期成像 公私研究，例如ADNI。 NC的目标是继续为 UCD ADRC并在神经影像的最前沿建立新功能。