Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

拉丁裔研究-神经认知衰老-阿尔茨海默病的调查

• 批准号: 10629449
• 负责人: Charles DeCarli
• 金额: $ 576.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629449
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Biological; Biological Aging; Biological Markers; Biology; Blood Vessels; Brain; California; Cardiovascular Diseases; Cardiovascular system; Censuses; Cerebrovascular Trauma; Chronic; Cognitive; Cognitive aging; Country; Data; Dementia; Diabetes Mellitus; Disparate; Disparity; Elderly; Epigenetic Process; Ethnic Origin; Exposure to; Face; Funding; Genes; Genetic; Genetic Risk; Genomics; Genotype; Goals; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Impaired cognition; Investigation; Knowledge; Latino; Latino Population; Magnetic Resonance Imaging; Measures; Mendelian randomization; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurocognitive; Pathology; Plasma; Population; Population Growth; Population Heterogeneity; Public Health; Research; Risk; Risk Factors; Structure; Study of Latinos; Subgroup; Texas; Therapeutic Intervention; Training; Vascular Diseases; Vascularization; Visit; aging brain; bilingualism; brain tissue; burden of illness; cardiovascular disorder risk; career; cohort; critical period; dementia risk; disease phenotype; ethnic difference; experience; health disparity; improved; middle age; neuroimaging marker; polygenic risk score; prevent; preventive intervention; racial population; social culture; sociocultural determinant; symposium; tau-1; vascular contributions

Abstract By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD) morbidity contributing to disparately high ADRD. CVD risk factors emerge early in midlife among Latinos, thereby increasing exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-date there has not been any study of Latinos with sufficiently deep CVD phenotyping and genotyping to adequately address this significant public health question. This scientific knowledge gap is a significant impediment to the field and public health given rapid Latino population growth projections, particularly for older adults. The Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer’s Disease (SOL-INCA-AD) will augment the ongoing large, representative and unique cohort with 10-years of advanced biomarkers of Alzheimer's disease to understand cognitive aging and impairment amongst diverse Latinos. Together with 10-years of cognitive measures, MRI, deep CVD phenotyping, genomics and rich sociocultural data, SOL-INCA-AD is a high priority study that will fill major scientific knowledge gaps that form barriers to progress for Latino ADRD research.

抽象的 到2060年，疾病预防控制中心（CDC 美国所有种族/种族群体的疾病和相关痴呆症（ADRD）病例。高高的主要解释 拉丁裔ADRD主要归因于早期，超过心血管疾病（CVD）发病率 不同的高度。 CVD风险因素在拉丁美洲人的中年早期出现，从而增加 暴露于精确敏感和高度血管化的脑组织。然而，迄今为止没有任何 具有足够深的CVD表型和基因分型的拉丁美洲人的研究，以充分解决这个问题 重要的公共卫生问题。这个科学知识差距是该领域的重大障碍， 公共卫生鉴于拉丁裔人口快速增长的预测，特别是对于老年人。研究 对神经认知衰老 - 阿尔茨海默氏病（Sol-Inca-AD）的拉丁美洲式评估将增加 持续的大型，代表和独特的队列，拥有10年的阿尔茨海默氏症的高级生物标志物 疾病了解拉丁裔潜水员的认知衰老和损害。与10年一起 认知测量，MRI，深CVD表型，基因组学和丰富的社会文化数据，Sol-Inca-AD是一个 高优先研究将填补主要的科学知识差距，从而构成拉丁裔的进步障碍 ADRD研究。