Core A: Administrative Core

核心A：行政核心

• 批准号: 10264494
• 负责人: DAVID ALAN BENNETT
• 金额: $ 26.61万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264494
• 关键词: Academic Medical Centers; Achievement; Address; Administrator; Advisory Committees; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapeutic; Biological Markers; Brain; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communication; Communities; Data; Dementia; Development; Diagnosis; Disease; Ensure; Etiology; Exercise; Faculty; Family Study; Funding; Funding Mechanisms; Future; Generations; Genetic Diseases; Goals; Infrastructure; Institution; International; Investments; Knowledge; Latino; Leadership; Monitor; NCI Scholars Program; National Institute on Aging; Pathogenesis; Pharmacology; Phenotype; Population Study; Precision Health; Reporting; Research; Research Institute; Research Personnel; Resource Sharing; Resources; Review Committee; base; cohort; collaborative environment; data hub; design; education research; health equity; innovation; meetings; neuroimaging; new therapeutic target; precision medicine; summer internship; user-friendly

ABSTRACT – ADMINISTRATIVE CORE The overall goal of the proposed Rush ADRC is to create an inter-disciplinary environment that supports innovative research on etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s dementia and related dementias (AD/ADRD). The Administrative (Admin) Core will exercise overall scientific leadership of the Rush ADRC to set the overall direction of the Rush ADRC, ensure optimal utilization of Rush ADRC resources, promote the implementation of the ADRD NAPA milestones, and serve as a resource for other aging and AD/ADRD activities at the national and local level. It will 1) ensure that each of the other Cores, and trainees reach their goals and greatest potential by establishing effective communication and interaction through the Executive Committee; 2) guide the use of institutional resources for the ADRC; 3) support a user- friendly mechanism to facilitate the use of Rush ADRC resources by the wider aging and AD/ADRD research community, locally, nationally, and internationally, through the Resource Distribution Committee; 4) identify and support high quality development projects and Rush ADRC Research Scholars; 5) ensure active and constructive participation in collaborative efforts with other organizations, advance research and knowledge of AD/ADRD, including RUMC, NIA ADRCs and other efforts; 6) monitor achievements and modify goals and future directions through the External Advisory Committee. These aims are supported through the careful design and integration of the Administrative Core with the other seven Cores and Research Education Component that comprise the Rush ADRC. The Rush ADRC addresses many of the NAPA Milestones including: 1) population studies via 3 community-based cohort studies and two affiliated cohort studies funded as R01s conducted by Rush ADRC investigators that are all harmonized to the ROS Core. They include multi-level, multi-region omic data for precision medicine and health equity as two cohorts are exclusively of Blacks and one of Latino and the two other studies are predominantly non-Latino white, 2) disease mechanisms via deep brain phenotyping, 3) translational clinical research – pharmacological through the generation of potential subjects for clinical trials, 4) biomarkers & diagnosis via neuroimaging and biofluid biomarkers, and 5) enabling infrastructure via our Resource Sharing Hub at https://www.radc.rush.edu/.

摘要 - 行政核心 拟议的Rush ADRC的总体目标是创建一个支持的跨学科环境 关于病因，发病机理，诊断，治疗和预防阿尔茨海默氏症的创新研究 和相关痴呆症（AD/ADRD）。行政（管理）核心将行使整体科学领导 Rush Adrc设定Rush ADRC的整体方向，确保最佳利用Rush ADRC 资源，促进ADRD NAPA里程碑的实施，并作为其他资源 国家和地方一级的衰老和广告/ADRD活动。它将1）确保每个其他核心，以及 学员通过建立有效的沟通和互动来实现他们的目标和最大的潜力 通过执行委员会； 2）指导ADRC的机构资源； 3）支持用户 - 更广泛的衰老和广告/ADRD研究，促进促进RUSH ADRC资源的友好机制 通过资源分销委员会，在本地，国内和国际上的社区； 4）识别和 支持高质量的开发项目和Rush ADRC研究学者； 5）确保活动并 建设性参与与其他组织的合作，提高研究和知识 AD/ADRD，包括RUMC，NIA ADRC和其他努力； 6）监视成就并修改目标和 通过外部咨询委员会的未来指示。 通过仔细的设计和行政核心与另一个的整合来支持这些目标 包括Rush ADRC的七个核心和研究教育部分。 RUSH ADRC地址 纳帕的许多里程碑包括：1）通过3项基于社区的队列研究和两个人口研究 Rush ADRC研究人员进行的R01资助的会员队列研究都与 ROS核心。它们包括用于精确医学和健康公平的多区域多区域的OMIC数据 队列仅是黑人，拉丁裔之一，另外两项研究主要是非latino 白色，2）通过深脑表型的疾病机制，3）翻译临床研究 - 药理 通过产生临床试验的潜在受试者，4）通过神经影像学和 生物流体生物标志物和5）通过我们的资源共享中心启用基础架构 https://www.radc.rush.edu/。