Validation of Video Administration of a Modified UDSv3 Cognitive Battery

改进的 UDSv3 认知电池的视频管理验证

• 批准号: 10370578
• 负责人: STEPHEN R RAPP
• 金额: $ 146.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370578
• 关键词: Academic Medical Centers; Achievement; Acute Respiratory Distress Syndrome; Address; Advisory Committees; Affect; Age; Agreement; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Assessment tool; Attention; COVID-19 pandemic; Characteristics; Classification; Clinical; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Education; Elderly; Enrollment; Episodic memory; Ethnic Origin; Evaluation; Failure; Financial Hardship; Frail Elderly; Future; Geographic Locations; Geography; Goals; Gold; Individual; Interruption; Language; Measures; Medical center; Minority; Modality; Neuropsychology; Outcome; Participant; Persons; Population; Protocols documentation; Psychometrics; Race; Research; Rural Population; Short-Term Memory; Site; Standardization; Subgroup; Tablet Computer; Telephone; Testing; Time; Transportation; Traumatic Brain Injury; Travel; Underserved Population; United States National Institutes of Health; Update; Validation; Visit; adjudicate; adjudication; base; clinical care; cognitive testing; ethnic minority; executive function; forest; meetings; metropolitan; mild cognitive impairment; preference; prevent; programs; racial and ethnic; recruit; remote assessment; remote grading; response; satisfaction; success; tool; virtual; working group; Academic Medical Centers; Achievement; Acute Respiratory Distress Syndrome; Address; Advisory Committees; Affect; Age; Agreement; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Assessment tool; Attention; COVID-19 pandemic; Characteristics; Classification; Clinical; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Education; Elderly; Enrollment; Episodic memory; Ethnic Origin; Evaluation; Failure; Financial Hardship; Frail Elderly; Future; Geographic Locations; Geography; Goals; Gold; Individual; Interruption; Language; Measures; Medical center; Minority; Modality; Neuropsychology; Outcome; Participant; Persons; Population; Protocols documentation; Psychometrics; Race; Research; Rural Population; Short-Term Memory; Site; Standardization; Subgroup; Tablet Computer; Telephone; Testing; Time; Transportation; Traumatic Brain Injury; Travel; Underserved Population; United States National Institutes of Health; Update; Validation; Visit; adjudicate; adjudication; base; clinical care; cognitive testing; ethnic minority; executive function; forest; meetings; metropolitan; mild cognitive impairment; preference; prevent; programs; racial and ethnic; recruit; remote assessment; remote grading; response; satisfaction; success; tool; virtual; working group

Project Summary This multi-site R01 aims to validate video-administered cognitive assessments for use by the Alzheimer’s Disease Research Centers (ADRCs) and other research programs whose activities have been interrupted by the COVID-19 pandemic, as well as for use in future initiatives when remote testing will enhance achievement of scientific goals. While face-to-face administration is the gold standard for cognitive assessments, conditions often arise that prevent participants from attending in-person visits. These barriers include transportation challenges, limited mobility, and financial hardship. There is also evidence that underserved populations, including rural populations and racial/ethnic minorities, are less likely to enroll in studies that require travel to an academic medical center for face-to-face testing. The proposed study will address these challenges by utilizing a video-adapted battery incorporating the Uniform Data Set version 3 (UDSv3) measures with additional measures that may serve as alternatives for UDSv3 measures not adaptable to video administration. We propose to fully validate these assessment tools for remote administration in partnership with the NIA and the National Alzheimer’s Coordinating Center (NACC), and carried out by a consortium of 12 ADRCs. Pilot data was gathered from 88 Wake Forest ADRC participants, deemed by in-person testing and adjudication to have normal cognition, MCI, or dementia, who were tested either by phone or video. Data show high participant ratings of tolerability, feasibility, and preference for video versus telephone assessment. There is also high concordance between video-administered and in- person test scores. Based on this collective data, we plan to fully validate a video-version of the UDSv3 battery in a range of cognitively, ethnically, and geographically diverse participants. We propose to administer remote video cognitive assessments, paired alongside annual in-person cognitive assessments, in counterbalanced order, to 500 existing participants from 12 ADRCs utilizing a computer tablet device, including those previously adjudicated as having normal cognition, MCI and dementia. Participants’ ratings of satisfaction with test condition and preference of test modality will be obtained, in addition to the psychometric characteristics of the video battery relative to face-to-face administration, including concurrent validity, and estimates of relative bias overall and across important subgroups (age, ethnicity, cognitive status) and mode of administration of individual tests. Concordance between adjudication outcomes will also be examined to assess the ability of the battery to distinguish normal cognition, MCI and dementia. We will assess the sensitivity of the video battery to detect longitudinal change in cognition in ADRC participants by repeating counterbalanced, in-person and remote assessments 2 years following initial evaluation. Completion of this project is critical to the ongoing success of cognitive assessment in the ADRC network.

项目摘要 这种多站点R01旨在验证视频管理的认知评估，以供 阿尔茨海默氏病研究中心（ADRC）和其他活动的研究计划 在远程测试将增强时，被Covid-19的大流行中断，以及未来的计划中使用 实现科学目标。虽然面对面管理是认知的黄金标准 评估，通常会出现条件，以防止参与者参加面对面的访问。这些障碍 包括运输挑战，有限的流动性和财务困难。也有证据表明 服务不足的人口，包括农村人口和种族/族裔少数民族，不太可能参加 需要前往学术医学中心进行面对面测试的研究。拟议的研究将 通过使用视频适应的电池编码统一数据集版本3来解决这些挑战 （UDSV3）采取其他措施的措施，可以用作UDSV3措施的替代方案 适应视频管理。我们建议完全验证这些评估工具的遥控工具 与NIA和国家阿尔茨海默氏症协调中心（NACC）合作管理 由12个ADRC的财团进行。飞行员数据来自88位Wake Forest ADRC参与者， 通过亲自测试和调整认为具有正常认知，MCI或痴呆症，他们接受了测试 通过电话或视频。数据显示可耐受性，可行性和视频偏好的参与评级很高 与电话评估。视频管理和内在之间也有很高的一致性 人测试分数。基于此集体数据，我们计划充分验证UDSV3的视频播放 在一系列认知，种族和地理上不同的参与者中进行电池。我们建议管理 远程视频认知评估与年度面对面认知评估配对， 平衡订单，使用计算机平板电脑设备，包括12位ADRC的现有参与者，包括 那些以前被调整为具有正常认知，MCI和痴呆症的人。参与者的评分 还将获得对测试条件的满意度和测试方式的偏好，此外 视频电池相对于面对面管理的心理测量特征，包括 并发有效性，以及对总体和重要亚组的相对偏见的估计（年龄，种族， 认知状态）和单个测试的给药方式。调整之间的一致性 还将检查结果，以评估电池区分正常认知的能力，MCI和 失智。我们将评估视频电池的灵敏度，以检测ADRC认知的纵向变化 参与者在初始2年后重复平衡，面对面和远程评估 评估。该项目的完成对于ADRC中认知评估的持续成功至关重要 网络。