Core H: Religious Orders Study Core

核心 H：宗教秩序研究核心

基本信息

批准号：
10669651
负责人：
DAVID ALAN BENNETT
金额：
$ 70.65万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10669651
关键词：
Address Aging Agreement Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Asia Australia Autopsy Biological Biological Markers Black Populations Blood Brain Brain Pathology Cell model Chicago Clinical Clinical Data Cognitive aging Collaborations Communities Country County Data Data Collection Dementia Diagnosis Disease Disease model Enrollment Ensure Etiology Europe Exclusion Funding Goals Health Heterogeneity Human Impaired cognition Infrastructure Latino Latino Population Link Magnetic Resonance Imaging Manuscripts Memory Methods Middle East Minority Molecular Profiling Nature Normalcy North America Online Systems Paper Pathogenesis Peer Review Persons Population Study Positioning Attribute Precision Health Process Recommendation Religion Reporting Research Research Personnel Research Project Grants Resource Sharing Resources Risk Factors Sister South America Specimen Strategic Planning Structure Systems Biology Woman Work brain magnetic resonance imaging data management data sharing design follow-up health disparity human data improved in vivo innovation men motor impairment multidisciplinary neuroimaging neuropathology open data operation outreach precision medicine predictive modeling public-private partnership recruit religious order study research clinical testing research study tool virtual

项目摘要

ABSTRACT – RELIGIOUS ORDERS STUDY CORE The overall goal of the Religious Orders Study (ROS) Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease and related dementias (AD/ADRD). The ROS Core will support a wide range of research studies that address several NAPA milesstones, including, 1) Population Studies; 2) Precision Medicine & Health Disparities; and 3) Disease Mechanisms, and Biomarkers & Diagnosis. The ROS Core, will 1) recruit, enroll, older Catholic religious men and women, who agree to annual clinical evaluations, blood draw and brain donation; 2) support studies: a) of the transition from no cognitive impairment (NCI) to MCI to the earliest stages of dementia; b) linking risk factors to normality, incident MCI, and incident AD/ADRD; c) of the progression and consequences of impaired motor function; and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA strategic plan, including studies that: a) recognize the heterogeneity and multifactorial nature of dementias; b) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; c) employ new research paradigms such as systems biology and innovative human cell modeling; d) enable rapid and extensive sharing of data, disease models, specimens, and support open science; e) build multidisciplinary translational teams in virtual and real spaces for these teams to operate; and f) develop new precompetitive public-private partnerships. The ROS Core has been in operation since 1994. It supports studies a) of the heteogenety of cognitive aging and mixed brain pathologies, b) of exensive molecular profiling, c) that employ systems biology and human cell modeling, d) whose data are rapidly disseminated via the RADC Hub, AMP-AD, and NIAGADS, e) that employ multi- and inter-disciplinary teams across the country and across the globe, and f) that work in public-private partnerships in the precompetitive space with AMD-AD and its sister studies. Excluding consortium papers, it has resulted in more than 650 peer-reviewed manuscripts that have been highly impactful on the field with 4 papers having 1000-1499 citations, 3 with 700-999, and 7 with 500-699. The top 10 papers were cited an average of 922 times. Further, ROS Core data and biospecimens have been shared with investigators at nearly all other NIA-funded AD Centers, across the county and north America, south America, Europe, the middle east, Asia and Australia as further evidence of the value of the resource (see Overall Tables 1-6 and Resource Sharing Plan). The ROS Core set the standard for harmonization with the Clinical and Latino Cores, affiliated studies Rush Memory and Aging Project and the Minority Aging Research Study, and with the Chicago Health and Aging Proect.

摘要 – 宗教秩序研究核心宗教秩序研究 (ROS) 核心的总体目标是支持高质量、前沿的研究阿尔茨海默病及相关疾病的病因、发病机制、诊断、治疗和预防项目 ROS 核心将支持针对多种痴呆症（AD/ADRD）的广泛研究。 NAPA 里程碑，包括 1) 人口研究；2) 精准医学与健康差异；3) 疾病机制、生物标志物和诊断。 ROS 核心将 1) 招募、登记老年天主教徒。同意每年进行临床评估、抽血和脑捐赠的宗教人士 2) 支持；研究：a) 从无认知障碍 (NCI) 到 MCI 到痴呆早期阶段的转变；将风险因素与正常情况、MCI 事件和 AD/ADRD 事件联系起来 c) 进展和后果；运动功能受损；3）促进符合建议的外部资助研究 2017 年 NIA 战略计划，包括以下研究： a) 认识到的异质性和多因素性质 b) 支持广泛的分子分析，以填补建立大规模人类数据的空白 c) 采用新的研究范式，例如系统生物学和创新的人类细胞建模；d) 实现数据、疾病模型、标本的快速和广泛共享， e) 在虚拟和现实空间中建立多学科转化团队运营团队；以及 f) 发展新的竞争前公私伙伴关系。 ROS 核心自 1994 年以来一直在运行。它支持 a) 认知衰老异质性的研究和混合脑病理学，b) 密集分子分析，c) 采用系统生物学和人类细胞建模，d) 其数据通过 RADC Hub、AMP-AD 和 NIAGADS 快速传播，e) 采用遍布全国和全球的多学科和跨学科团队，以及 f) 在公私部门开展工作与 AMD-AD 及其姐妹研究在竞争前领域的合作伙伴关系，不包括联盟论文。已产生 650 多篇经过同行评审的手稿，这些手稿在该领域具有很大的影响力，其中 4 被引次数为1000-1499的论文，700-999的论文有3篇，500-699的论文有7篇。此外，ROS 核心数据和生物样本已与研究人员共享。几乎所有其他 NIA 资助的 AD 中心，遍布全县以及北美、南美、欧洲、中东、亚洲和澳大利亚作为资源价值的进一步证据（见总表 1-6 和资源共享计划）。ROS 核心设定了与临床和拉丁裔核心协调的标准，附属研究“拉什记忆与衰老项目”和“少数民族衰老研究”，并与芝加哥健康与老龄化项目。