Core H: Religious Orders Study Core

核心 H：宗教秩序研究核心

• 批准号: 10472772
• 负责人: DAVID ALAN BENNETT
• 金额: $ 70.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472772
• 关键词: Address; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Australia; Autopsy; Biological; Biological Markers; Black Populations; Blood; Brain; Brain Pathology; Cell model; Chicago; Clinical; Clinical Data; Cognitive aging; Collaborations; Communities; Country; County; Data; Data Collection; Dementia; Diagnosis; Disease; Disease model; Enrollment; Ensure; Etiology; Europe; Far East; Funding; Goals; Health; Heterogeneity; Human; Impaired cognition; Infrastructure; Latino; Latino Population; Link; Magnetic Resonance Imaging; Manuscripts; Memory; Methods; Middle East; Minority; Molecular Profiling; Nature; Normalcy; North America; Online Systems; Paper; Pathogenesis; Peer Review; Persons; Population Study; Precision Health; Process; Recommendation; Religion and Spirituality; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Sister; South America; Specimen; Strategic Planning; Structure; Systems Biology; Time; Woman; Work; brain magnetic resonance imaging; data management; data sharing; design; follow-up; health disparity; human data; improved; in vivo; innovation; men; motor impairment; multidisciplinary; neuroimaging; neuropathology; open data; operation; outreach; precision medicine; predictive modeling; public-private partnership; recruit; religious order study; research clinical testing; research study; tool; virtual

ABSTRACT – RELIGIOUS ORDERS STUDY CORE The overall goal of the Religious Orders Study (ROS) Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease and related dementias (AD/ADRD). The ROS Core will support a wide range of research studies that address several NAPA milesstones, including, 1) Population Studies; 2) Precision Medicine & Health Disparities; and 3) Disease Mechanisms, and Biomarkers & Diagnosis. The ROS Core, will 1) recruit, enroll, older Catholic religious men and women, who agree to annual clinical evaluations, blood draw and brain donation; 2) support studies: a) of the transition from no cognitive impairment (NCI) to MCI to the earliest stages of dementia; b) linking risk factors to normality, incident MCI, and incident AD/ADRD; c) of the progression and consequences of impaired motor function; and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA strategic plan, including studies that: a) recognize the heterogeneity and multifactorial nature of dementias; b) support extensive molecular profiling to fill the gaps in large-scale human data needed to build predictive models of disease and wellness; c) employ new research paradigms such as systems biology and innovative human cell modeling; d) enable rapid and extensive sharing of data, disease models, specimens, and support open science; e) build multidisciplinary translational teams in virtual and real spaces for these teams to operate; and f) develop new precompetitive public-private partnerships. The ROS Core has been in operation since 1994. It supports studies a) of the heteogenety of cognitive aging and mixed brain pathologies, b) of exensive molecular profiling, c) that employ systems biology and human cell modeling, d) whose data are rapidly disseminated via the RADC Hub, AMP-AD, and NIAGADS, e) that employ multi- and inter-disciplinary teams across the country and across the globe, and f) that work in public-private partnerships in the precompetitive space with AMD-AD and its sister studies. Excluding consortium papers, it has resulted in more than 650 peer-reviewed manuscripts that have been highly impactful on the field with 4 papers having 1000-1499 citations, 3 with 700-999, and 7 with 500-699. The top 10 papers were cited an average of 922 times. Further, ROS Core data and biospecimens have been shared with investigators at nearly all other NIA-funded AD Centers, across the county and north America, south America, Europe, the middle east, Asia and Australia as further evidence of the value of the resource (see Overall Tables 1-6 and Resource Sharing Plan). The ROS Core set the standard for harmonization with the Clinical and Latino Cores, affiliated studies Rush Memory and Aging Project and the Minority Aging Research Study, and with the Chicago Health and Aging Proect.

摘要 - 宗教秩序研究核心 宗教秩序研究（ROS）核心的总体目标是支持高质量，尖端，研究 关于病因，发病机理，诊断，治疗和预防阿尔茨海默氏病及相关的项目 痴呆症（AD/ADRD）。 ROS核心将支持广泛的研究，以解决几个研究 NAPA里程碑，包括1）人口研究； 2）精确医学与健康差异； 3） 疾病机制以及生物标志物与诊断。 ROS核心，将1）招募，入学，老年天主教徒 宗教男女，同意年度临床评估，抽血和脑部捐赠； 2）支持 研究：a）从没有认知障碍（NCI）到MCI到最早痴呆阶段的过渡； b） 将风险因素与正常性，事件MCI和事件AD/ADRD联系起来； c）进展和后果 运动功能受损； 3）促进与外部资助的研究相吻合的研究 2017年NIA战略计划，包括：a）认识到异质性和多因素的性质 痴呆症； b）支持广泛的分子分析，以填补构建所需的大规模人类数据的空白 疾病和保健的预测模型； c）员工新的研究范式，例如系统生物学和 创新的人类细胞建模； d）能够快速而广泛地共享数据，疾病模型，标本， 并支持开放科学； e）在虚拟和真实空间中建立多学科翻译团队 团队要运营； f）建立新的预竞争性公私伙伴关系。 自1994年以来，ROS核心一直在运行。它支持研究a）认知衰老的异质性 和混合脑病理，b）极端分子分析，c）员工系统生物学和人类细胞 建模，d）其数据通过RADC中心，AMP-AD和Niagads迅速传播，e）使用 全国和全球的多学科团队以及在公私方面工作的f） 与AMD-AD及其姊妹研究的预竞争空间的合作伙伴关系。不包括财团文件 已经产生了650多个同行评审的手稿，这些手稿对该领域产生了极大的影响。 论文具有1000-1499的引用，3篇论文为700-999，其中7条带有500-699。排名前10的论文被引用了 平均922次。此外，ROS核心数据和生物测量已与研究人员共享 几乎所有其他NIA资助的广告中心，遍布县和北美，南美，欧洲， 中东，亚洲和澳大利亚作为资源价值的进一步证据（请参阅总体表1-6和 资源共享计划）。 ROS核心为与临床和拉丁裔核心协调的标准设定了标准 会员研究紧急记忆和衰老项目以及少数族裔老化研究，以及 芝加哥的健康和老龄化培训。