Research Education Component

研究教育部分

基本信息

批准号：
10263690
负责人：
Kyle M Walsh
金额：
$ 23.99万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10263690
关键词：
Address Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American American Indians Basic Science Biological Markers Biology of Aging Capsicum Clinic Clinical Clinical Investigator Clinical Research Collaborations Communication Community Developments Development Discipline Doctor of Philosophy Educational Curriculum Educational workshop Environment Exposure to Face Faculty Fostering Foundations Future Goals Health Historically Black Colleges and Universities Institution Journals Knowledge Learning Longevity Manuscripts Mediating Medical Medical Research Medical Students Mentors Mentorship Neurosciences North Carolina Outcome Pathologic Pathology Patient Recruitments Population Positioning Attribute Postdoctoral Fellow Preventive measure Research Research Design Research Ethics Research Personnel Research Support Research Training Resources Sampling Science Scientist Site Specimen Statistical Data Interpretation Students Talents Training Training Programs Training and Education Translational Research Underserved Population Universities age related base biobank career disparity reduction education research experience health care delivery improved innovation insight interdisciplinary collaboration interest medical specialties multidisciplinary next generation novel online course posters programs research data dissemination responsible research conduct rural healthcare summer research symposium targeted delivery training opportunity

项目摘要

ABSTRACT - Research Education Component The primary goal of the Duke/UNC Alzheimer’s Disease Research Center (ADRC) Research Education Component (REC) is to develop future leaders in Alzheimer’s disease (AD) and AD-related dementias (AD+ADRD) research, including within the Center’s theme of identifying age-related changes across the lifespan that mediate the development, progression and experience of AD. There are unique challenges facing AD+ADRD research, including limited training in researchprinciples, a lack of early-career exposure to AD+ADRD research, and research silos that impede knowledge transfer between basic and clinical investigators. To overcome these challenges, the REC research training program will broadly disseminate a foundational AD+ADRD research curriculum spanning both basic and clinical research, delivered to five universities across North Carolina and made available to the public (Aim 1). In addition to delivering broad cross-campus AD+ADRD research education, the REC will solicit “REC Scholar” applications and select 2-4 scholars annually from a diverse pool of talented early-career AD+ADRD investigators (Aim 2). REC Scholars will receive intensive research training and tailored professional development under the guidance of a faculty mentorship team comprised of a clinical researcher and a basic scientist. The REC will expand the reach of its training program by leveraging existing training assets at Duke and UNC (e.g., Duke’s “Creating AD Researchers for the Next Generation” STARR Program (R38), UNC’s “Summer Research Training in Aging for Medical Students” (T35) and Duke’s Claude D. Pepper Older Americans Independence Center and Edward R. Roybal Center). The REC’s close integration with the other Duke/UNC ADRC cores provides synergistic interactions with key research training opportunities in specimen biobanking, statistical analysis, study design, pathologic sample analysis, patient recruitment, and research dissemination. The REC will diversify AD+ADRD researcher perspectives and the workforce by partnering with UNC Pembroke (a designated historically American Indian university), NC Central University (an historically black university), and East Carolina University (an institution with expertise in rural healthcare delivery) (Aim 3). Investigators and trainees at these institutions will participate in monthly research colloquia, the online curriculum, monthly journal clubs, research consultancies that leverage Duke/UNC expertise to augment AD+ADRD research at other sites, and the annual Symposium for Learning about Alzheimer’s disease-related Medical research at Duke and UNC (SLAM-DUNC), hosted by each institution in turn. REC programming will foster interest in AD+ADRD research and cultivate the multidisciplinary expertise needed in its next generation of leaders. By fostering interactions among investigators from different disciplines and backgrounds through the REC’s innovative and inclusive programming, the REC will develop new AD+ADRD researchers prepared to engage in interdisciplinary collaborations aimed at improving health outcomes and reducing disparities by bringing novel treatments to the clinic and novel preventive measures to the population.

摘要 - 研究教育部分杜克大学/北卡罗来纳大学阿尔茨海默病研究中心 (ADRC) 研究教育的主要目标组成部分 (REC) 旨在培养阿尔茨海默病 (AD) 和 AD 相关痴呆症的未来领导者 (AD+ADRD) 研究，包括在该中心的主题内识别整个生命周期中与年龄相关的变化调节 AD 的发展、进展和经历面临着独特的挑战。 AD+ADRD 研究，包括有限的研究原理培训、缺乏早期职业接触 AD+ADRD 研究以及阻碍基础研究人员和临床研究人员之间知识转移的研究孤岛。为了克服这些挑战，REC 研究培训计划将广泛传播基础知识 AD+ADRD 研究课程涵盖基础研究和临床研究，交付给全国五所大学除了提供广泛的跨校区 AD+ADRD 之外，还向公众开放（目标 1）。研究教育，REC将征集“REC学者”申请，并从研究教育中选出2-4名学者不同的才华横溢的早期职业 AD+ADRD 研究者（目标 2）将接受强化培训。在教师导师团队的指导下进行研究培训和量身定制的专业发展 REC 由一名临床研究员和一名基础科学家组成，将扩大其培训计划的范围。通过利用杜克大学和北卡罗来纳大学的现有培训资产（例如杜克大学的“为下一代培养 AD 研究人员”） Generation”STARR 计划 (R38)，北卡罗来纳大学的“医学生老龄化夏季研究培训”(T35) 以及杜克大学的克劳德·D·佩珀美国老年人独立中心和爱德华·R·罗伊巴尔中心）。 REC 与其他 Duke/UNC ADRC 内核的紧密集成提供了与关键的协同交互标本生物样本库、统计分析、研究设计、病理样本方面的研究培训机会 REC 将使 AD+ADRD 研究人员多样化。通过与北卡罗来纳大学彭布罗克分校（指定的历史悠久的美洲印第安人）合作，了解观点和劳动力大学）、北卡罗来纳中央大学（一所历史悠久的黑人大学）和东卡罗来纳大学（一所机构）具有农村医疗保健提供方面的专业知识）（目标 3）。在每月的研究座谈会、在线课程、每月的期刊俱乐部、研究咨询机构中，杜克大学/北卡罗来纳大学的专业知识，以增强其他地点的 AD+ADRD 研究，以及年度学习研讨会关于杜克大学和北卡罗来纳大学 (SLAM-DUNC) 的阿尔茨海默病相关医学研究，由各机构主办反过来，REC 项目将培养对 AD+ADRD 研究的兴趣并培养多学科专业知识。下一代领导者需要通过促进不同学科的研究人员之间的互动。通过 REC 的创新和包容性计划，REC 将开发新的 AD+ADRD 研究人员准备开展旨在改善健康的跨学科合作通过将新的治疗方法引入临床并采取新的预防措施来减少差异人口。