Tissue and Research Pathology Services

组织和研究病理学服务

• 批准号: 10254106
• 负责人: RAJIV DHIR
• 金额: $ 11.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-10 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10254106
• 关键词: Algorithmic Analysis; American; Antibodies; Apoptosis; Bioinformatics; Biological; Biological Specimen Banks; Bromodeoxyuridine; Budgets; Cancer Center; Cancer Center Support Grant; Cell Proliferation; Clinical; Clinical Data; Clinical Laboratory Information Systems; Clinical Research; Collection; Community Hospitals; Computerized Medical Record; Cutaneous Melanoma; Data; Databases; Development; Diagnostic; Equipment; Ethics; Evaluation; Frozen Sections; Funding; Glass; Goals; Head and neck structure; Health Sciences; Histology; Hospitals; Hour; Human; Image; Image Analysis; Image Enhancement; Immunohistochemistry; Immunologic Monitoring; Individual; Information Retrieval; Institutional Review Boards; Investigation; Laboratories; Lung; Malignant Neoplasms; Malignant neoplasm of ovary; Medical; Modeling; Monitor; Nuclear; Paraffin Tissue; Pathologist; Pathology; Patients; Pattern; Pediatric Hospitals; Plant Roots; Play; Presbyterian Church; Price; Process; Proteomics; Protocols documentation; Registries; Research; Research Personnel; Resource Sharing; Resources; Retrieval; Role; Sampling; Science; Services; Site; Skin Cancer; Slide; Specimen; Stains; Supervision; System; Systems Analysis; TdT-Mediated dUTP Nick End Labeling Assay; Techniques; Text; The Cancer Genome Atlas; Time; Tissue Banks; Tissue Microarray; Tissue Preservation; Tissue Sample; Tissues; Translational Research; Triage; Trichrome stain method; Universities; Woman; Work; automated image analysis; biobank; college; cost; data centers; data management; design; experience; imaging facilities; innovation; interest; liquid crystal polymer; member; morphometry; novel; pre-clinical research; programs; quantitative imaging; research facility; research study; sample collection; service utilization; tumor; whole slide imaging

Abstract: Tissue and Research Pathology Services (TARPS) One of the essential components of any translational research investigation is the availability of high quality, appropriately selected human biospecimen samples. The Hillman Cancer Center (HCC) recognized the value of a good, systematic, scientifically, and ethically correct biospecimen repository more than 18 years ago and implemented a system-wide initiative for tissue and biological specimen accrual with the establishment of the Tissue and Research Pathology Service (TARPS) Shared Resource under the umbrella of the University of Pittsburgh (Pitt) resource also known as the Pitt Biospecimen Core (formerly the Health Sciences Tissue Bank). TARPS has been housed and extensively supported by HCC and the Department of Pathology. This has led to the development of a well-organized biospecimen resource, providing high-quality, well-banked specimens with extensive database support providing the clinical annotation so essential to good research. TARPS is a CAP-certified biorepository and serves as the central hub, acquiring and triaging biospecimen materials and de-identified patient information. It is currently housed within the Department of Pathology diagnostic evaluation facilities, thus providing immediate access to specimens and patient information of interest. The resource has Pathologist administrative oversight and medical supervision at the three flagship hospitals (Presbyterian, Shadyside, Magee), and the largest community hospital (Passavant), with plans in progress to add Children’s Hospital of Pittsburgh later in 2019. At HCC, TARPS has played an instrumental role in supporting multi-investigator and multi-institutional efforts including: The Cancer Genome Atlas Project (TCGA); the caHUB project as a funded site for the Biospecimen Pre-analytical Variables (BPV) task order; the NCI’s Clinical Proteomic Tumor Analysis Consortium (CPTAC), SPOREs in lung, head and neck, melanoma and skin, and ovarian cancers and many other collaborative team science projects. In FY2019, 65 out of 121 users were HCC members representing 6 CCSG research programs (CB, CEP, CII, CT, CV and GS). Usage was stable from 79% to 91% between 2015 and 2019.

摘要：组织和研究病理服务（TARPS） 任何翻译研究投资的重要组成部分之一是高质量的可用性， 适当选择的人类生物测量样品。希尔曼癌症中心（HCC）认识到价值 18年前，有一个良好，系统，科学和道德上正确的生物传播存储库， 建立了一项针对组织和生物标本准确性的全系统倡议 组织与研究病理服务（TARPS）在大学的保护下共享资源 匹兹堡（PITT）资源也称为Pitt Biospececimen Core（以前是健康科学组织 银行）。篷布已由HCC和病理学部广泛地饲养和广泛支持。这 导致了组织良好的生物循环资源的发展，提供了高质量，良好的资源 具有广泛数据库支持的标本提供了对良好研究至关重要的临床注释。 防水布是一个经过帽帽认证的生物库，并用作中央枢纽 材料和去识别的患者信息。它目前位于病理部 诊断评估设施，从而立即访问标本和患者信息 兴趣。该资源在三个旗舰店中具有病理学家的行政监督和医疗监督 医院（长老会，夏迪赛德，马吉）和最大的社区医院（帕瓦特），计划有计划 在2019年晚些时候增加匹兹堡儿童医院的进展。 在HCC，防水布在支持多侵略器和多机构的努力方面发挥了重要作用 包括：癌症基因组图集项目（TCGA）； CAHUB项目是生物遇到的资助网站 分析前变量（BPV）任务顺序； NCI的临床蛋白质组学分析联盟（CPTAC）， 肺部的孢子，头颈部，黑色素瘤和皮肤，以及卵巢癌以及许多其他合作团队 科学项目。在2019财年，有65名用户是HCC成员，代表6个CCSG研究 程序（CB，CEP，CII，CT，CV和GS）。在2015年至2019年期间，使用率从79％稳定在91％。