Tissue Resource and Morphology Core (TRMC)

组织资源和形态核心 (TRMC)

• 批准号: 10002342
• 负责人: RAJIV DHIR
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002342
• 关键词: Animal Model; Biocompatible Materials; Biological; Bladder; Blood; Core Facility; Data; Data Collection; Development; Equipment and supply inventories; Genitourinary system; Health Sciences; Histology; Immunohistochemistry; Institutional Review Boards; Morphology; Pathologist; Pathology; Patients; Prostate; Prostatic Diseases; Research; Sampling; Services; Specimen; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Training; Universities; Urine; base; clinically relevant; human tissue; programs; success; tissue culture; tissue resource

Abstract: Results from tissue culture and animal models provide important information, but must be validated in human tissue to be considered clinically relevant. Thus, the success of this O'Brien Center will depend upon the availability of high quality, appropriately selected human tissue specimens. The Tissue Resources and Morphology Core (TRMC) will supply such material. The TRMC will be based on the Health Sciences Tissue Bank, a core facility that has been accruing prostate tissue from BPH patients for over 15 years. The Director of the Health Sciences Tissue Bank, Dr. Rajiv Dhir, a board certified pathologist with training in genitourinary pathology, will serve as the TRMC Director. Dr. Dhir will assure the proper use and analysis of BPH specimens in the proposed projects. The TRMC will provide an array of services: (1) Procurement of normal and diseased prostates and bladders; (2) Banking of specimens; (3) Data collection to annotate samples, specimen data entry, and inventory management; (4) Morphology support for appropriate case selection for the proposed studies; (5) Histology support and immunohistochemistry. Tissue microarray development will be done for high throughput assessment, if needed. (6) Support and assistance for Institutional Review Board issues.

抽象的： 组织培养和动物模型的结果提供了重要信息，但必须在人类中进行验证 组织在临床上相关。因此，这个奥布莱恩中心的成功将取决于 高质量，适当选择的人体组织标本的可用性。组织资源和 形态核心（TRMC）将提供此类材料。 TRMC将基于健康科学组织 Bank是一种核心设施，该设施一直从BPH患者中获得前列腺组织已有15年以上。导演 健康科学组织库，董事会认证病理学家Rajiv Dhir博士接受了泌尿生殖器的培训 病理学将担任TRMC主管。 DHIR博士将确保对BPH的适当使用和分析 拟议项目中的标本。 TRMC将提供一系列服务：（1） 以及患病的前列物和膀胱； （2）标本的银行； （3）注释样本的数据收集， 标本数据输入和库存管理； （4）形态支持为适当的病例选择 拟议的研究； （5）组织学支持和免疫组织化学。组织微阵列的发展将是 如果需要，可以进行高通量评估。 （6）机构审查委员会的支持和协助 问题。