Cannabis use among older adults: Potential risks and benefits to an aging population

老年人吸食大麻：人口老龄化的潜在风险和益处

• 批准号: 10563144
• 负责人: Angela Bryan
• 金额: $ 60.85万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10563144
• 关键词: Accounting; Acute; Adult; Age; Aging; American; Anxiety; Applications Grants; Area; Behavioral; Benefits and Risks; Blood; Cannabidiol; Cannabinoids; Cannabis; Cannabis policy; Cannabis retail; Colorado; Control Groups; Data; Decision Aid; Decision Making; Elderly; Epidemiology; Exercise; Goals; Harm Reduction; Human; Laboratories; Legal; Life; Medical; Medical Marijuana; Mental Depression; Motor; Neurocognition; Neurocognitive; Older Population; Outcome; Pain; Participant; Patient Self-Report; Patients; Pharmacology; Physiology; Play; Population; Prevalence; Process; Public Health; Publishing; Qualitative Methods; Quality of life; Recreation; Reporting; Research; Research Infrastructure; Risk; Role; Schedule; Sleep; Sleeplessness; Surveys; Symptoms; Tetrahydrocannabinol; Time; Work; age group; aged; aging population; cognitive function; comparison group; design; epidemiologic data; experience; impression; innovation; interest; marijuana legalization; marijuana use; marijuana user; motor control; negative affect; patient oriented; pharmacologic; prospective; recruit; symptomatic improvement; virtual

Project Summary The population of older adults in the U.S. is increasing dramatically, doubling from 48 million to 88 million by the year 2050. As more Americans live longer, the challenge is to assure that quality of life is being maintained along with quantity of life. Research is beginning to focus on understanding the changing physiology underlying normal human aging, as well as expand on behavioral and pharmacological strategies that may assist older adults to maximize their later years, and recent surveys suggest that some may believe that legalized cannabis products have a role to play. Simultaneously, the increasing legalization and acceptance of cannabis is occurring at a rapid pace. Older adults are the fastest growing group of cannabis users in the U.S., with prevalence up by 250% for in some age groups, who perceive virtually no risk of using cannabis monthly (85.3%) or even weekly (79%). National Surveys also showed that older adults were more likely to use cannabis for medicinal purposes than for recreational purposes, and common reasons for use include pain, anxiety, depression, and insomnia. There are obvious and critical questions that this situation poses. First, do older adults experience relief from their symptoms and does this depend on the constituent cannabinoids of the product they are using? Second, are there impacts on neurocognition and motor control that might be harmful, or even potentially beneficial, and do these, too, depend on the cannabinoid profile of the products being used? Third, how can we assist older adults in decision-making regarding cannabis? The overarching goal of this grant application is to leverage our innovative mobile pharmacology laboratory approach and existing aging research infrastructure to better understand the effects of legal market cannabis in adults aged 60 and over. To that end, the proposed research will utilize a prospective, patient-centered observational design to recruit and assess older adults who are interested in using cannabis for pain, trouble sleeping, or negative affect and a comparison group who are not interested in cannabis use. Users will choose and use one of three types of edible cannabis products (i.e., a CBD dominant product, a THC+CBD product, or a THC dominant product) for a total of three months. The proposed research has three aims. First, we will explore the effects of edible cannabis of varying composition among older adults who desire to use cannabis to treat their pain, trouble sleeping, or negative affect (depression/anxiety) as compared to a non-sing comparison group assessed by changes in the Patient Global Impression of Change scale. Second we will explore the effects of edible cannabis use of varying composition on neurocognition and motor control both acutely and over time among older adults. Finally, we will examine the process by which older adult cannabis users decide what type of cannabis product they prefer. Pursuit of these aims has tremendous

项目摘要 美国老年人的人口急剧增加，从4800万增加了一倍，达到8800万 到2050年。随着越来越多的美国人的寿命，挑战是确保生活质量正在 维持生命的数量。研究开始专注于理解变化 正常人类衰老的生理学以及行为和药理策略的扩展 这可能有助于老年人最大化他们的后期，最近的调查表明，有些人可能会相信 合法的大麻产品可以发挥作用。同时，越来越多的合法化和 接受大麻的接受速度很快。老年人是生长最快的大麻 在美国的用户，某些年龄组的患病率上升了250％，他们几乎没有使用的风险 每月大麻（85.3％）甚至每周（79％）。国家调查还表明，老年人更多 可能将大麻用于药用目的而不是用于娱乐目的，而使用的常见原因 包括疼痛，焦虑，抑郁和失眠。这种情况有明显而关键的问题 姿势。首先，老年人是否可以缓解症状，这取决于组成部分 他们使用的产品的大麻素？其次，对神经认知和运动控制有影响 这可能是有害的，甚至可能有益的，并且也可以做到这一点 产品被使用？第三，我们如何帮助老年人就大麻的决策做出决策？ 该赠款申请的总体目标是利用我们创新的移动药理学实验室 方法和现有的老化研究基础设施，以更好地了解法律市场大麻的影响 60岁及以上的成年人。为此，拟议的研究将利用一个预期的，以患者为中心的 观察性设计以招募和评估有兴趣使用大麻疼痛的老年人 睡眠困难或负面影响以及对使用大麻不感兴趣的比较组。 用户将选择并使用三种类型的可食用大麻产品之一（即CBD主导产品，一个 THC+CBD产品或THC主要产品）总共三个月。拟议的研究有三个 目标。首先，我们将探索希望的老年人中不同成年人的可食用大麻的影响 使用大麻来治疗他们的疼痛，睡眠麻烦或负面影响（抑郁/焦虑）与 通过患者全球变化量表的全球印象的变化评估的非辅助比较组。第二 我们将探索可食用大麻使用不同组成对神经认知和运动控制的影响 在老年人中，随着时间的流逝和随着时间的流逝。最后，我们将研究老年人的过程 大麻用户决定他们喜欢哪种类型的大麻产品。追求这些目标有很大的