Exercise adherence and cognitive decline: Engaging with the Black community to develop and test a goal-setting and exercise intensity intervention

运动坚持和认知能力下降：与黑人社区合作制定和测试目标设定和运动强度干预措施

• 批准号: 10767102
• 负责人: Angela Bryan
• 金额: $ 37.94万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10767102
• 关键词: Adherence; Adopted; Adult; Affect; Affective; African American; African American population; Age; Age-associated memory impairment; Aging; Alleles; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Amyloid beta-Protein; Apolipoprotein E; Area; Awareness; Behavior; Benchmarking; Biological; Biological Markers; Black American; Black race; Cardiovascular Diseases; Chronic Disease; Code; Collaborations; Communities; Data; Demographic Factors; Development; Diabetes Mellitus; Disparity; Effectiveness; Effectiveness of Interventions; Equity; Ethnic Origin; Exercise; Feedback; Genes; Genetic; Genotype; Goals; Guidelines; Health; Health behavior and outcomes; Immigrant; Immigrant community; Impaired cognition; Individual; Intervention; Intervention Trial; Life Style; Light; Literature; Maintenance; Measures; Mediating; Mediator; Meta-Analysis; Methods; Moderate Exercise; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Participant; Persons; Phase; Physical activity; Plasma; Population; Prevalence; Prevention; Process; Public Health; Race; Recommendation; Reporting; Research; Research Design; Risk; Sampling; Self Efficacy; Strenuous Exercise; Structural Racism; System; Techniques; Testing; Translating; Treatment Efficacy; Underrepresented Populations; Vascular Dementia; Vulnerable Populations; Work; World Health Organization; acceptability and feasibility; behavioral adherence; community engaged research; design; economic cost; efficacy testing; exercise adherence; exercise intensity; exercise intervention; exercise regimen; feasibility trial; health disparity; human old age (65+); hyperphosphorylated tau; intervention effect; intrinsic motivation; meetings; member; metropolitan; mild cognitive impairment; moderate-to-vigorous physical activity; mortality; neglect; neurofilament; people of color; person centered; pilot trial; psychologic; randomized trial; recruit; response; risk mitigation; socioeconomics; tau Proteins; tau-1; theories; vigorous intensity

Project Summary The average age of the U.S. population is rapidly increasing and with it the prevalence of age-associated cognitive decline. Furthermore, the risk for age-associated cognitive decline may disproportionately affect many historically underrepresented groups. Regular physical activity (PA) is associated with lower risk for cognitive decline, but many people struggle to maintain PA over the long term. Goal setting presents one promising avenue to facilitate PA maintenance and has strong public health significance. Likewise, exercise intensity may further this aim as challenging goals for higher intensity PA may provide the most robust PA maintenance. Importantly, however, most existing research on goal setting, exercise intensity, and theory- based exercise interventions overall has been generated among high SES, low diversity samples, and the field has largely neglected this disparity, with recent reviews and meta-analyses failing to even report racial, ethnic, or socioeconomic demographic factors. While systems of oppression and structural racism undoubtedly influence disparities in health behavior and outcomes, it is also possible that existing individual-level theory- based interventions are not culturally appropriate for many communities, such as African Americans and Black immigrants (i.e., the Black community). In this application, we will take a community engaged research approach to tailor and test a theory-based intervention promoting adherence to recommended levels of PA in the Black community using the technique of person-centered goal setting. We will determine whether prescriptions of different PA intensities moderate the effectiveness of these goal-setting approaches and test the theoretical mediators associated with the effectiveness of these interventions on behavioral adherence and healthy changes in biomarkers associated with cognitive decline. Therefore, the overarching goals of this project are to take a community engaged research approach to 1) tailor a theory-based goal-setting exercise intervention in the Denver metropolitan area Black community (R61) and 2) utilize the Operating Conditions Framework to test the efficacy of the intervention for PA adherence, weekly volume of exercise, and changes in biomarkers associated with cognitive decline (R33). These objectives will be met through collaboration with our community partner The Gyedi Project to focus on and fully engage the Black community in the Denver metropolitan area in the research process.

项目摘要 美国人口的平均年龄正在迅速增加，随着年龄相关的流行 认知能力下降。此外，与年龄相关的认知能力下降的风险可能不成比例 许多历史上代表性不足的群体。定期体育锻炼（PA）与较低的风险有关 认知能力下降，但许多人在长期内努力维持PA。目标设定给出一个 有望促进PA维护并具有强大的公共卫生意义的途径。同样，锻炼 强度可能会进一步进一步，因为更高强度PA的挑战性目标可能会提供最强大的PA 维护。但是，重要的是，大多数现有的有关目标设定，运动强度和理论的研究 - 在高SES，低多样性样本和领域中，总体上已经产生了基于运动干预措施 在很大程度上忽略了这一差异，最近的评论和荟萃分析甚至没有报告种族，种族， 或社会经济人口因素。毫无疑问，压迫和结构性种族主义制度 影响健康行为和结果的差异，现有的个人级理论也可能 基于干预措施在文化上不适合许多社区，例如非裔美国人和黑人 移民（即黑人社区）。在此应用程序中，我们将进行社区参与的研究 量身定制和测试基于理论的干预措施，以促进遵守建议的PA水平 黑人社区使用以人为本目标设定的技术。我们将确定是否 不同PA强度的处方可使这些目标设定方法的有效性和测试 与这些干预措施对行为遵守的有效性相关的理论调解者 与认知能力下降有关的生物标志物的健康变化。因此，这个总体目标 项目将采用社区参与的研究方法1）量身定制基于理论的目标设定 丹佛都会区黑人社区（R61）的运动干预和2） 操作条件框架以测试干预措施遵守的疗效，每周 运动量以及与认知下降相关的生物标志物的变化（R33）。这些 将通过与我们的社区合作伙伴The Gyedi项目的合作来实现目标，以专注于和完全 参与丹佛都会区的黑人社区参与研究过程。