Enhancing Research capacity for Sickle Cell Disease and related NCDs across the Lifespan in Uganda. ''Enrich Project''

加强乌干达全生命周期镰状细胞病和相关非传染性疾病的研究能力。

• 批准号: 10665128
• 负责人: Sarah Kiguli
• 金额: $ 24.73万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665128
• 关键词: Accounting; Acute Renal Failure with Renal Papillary Necrosis; Adult; Advocacy; Affect; Africa; Africa South of the Sahara; Brain; Cessation of life; Child; Childhood; Chronic; Disease; Growth; Health Sciences; Heart; High Prevalence; Home; Intervention; Kidney; Life Expectancy; Longevity; Lung; Microalbuminuria; Morbidity - disease rate; Neurocognitive Deficit; Nutritional; Patients; Perinatal; Persons; Population; Professional Education; Research; Research Training; Scientist; Sickle Cell Anemia; Stroke; Survivors; Training; Uganda; Universities; Work; acute chest syndrome; clinical care; college; cost; health related quality of life; innovation; mortality; multidisciplinary

Project Abstract: Chronic Non-communicable Diseases and Disorders (NCDs) are the leading cause of global mortality, accounting for 71% of all deaths. It is projected that by 2030, deaths from NCDs in Africa will exceed deaths due to communicable, maternal, perinatal, and nutritional diseases combined. Sub-Saharan Africa is home to 90% of the 300,000 children born worldwide with Sickle Cell Disease (SCD) annually and SCD in Sickle Cell Anemia SSA is associated with 16% of childhood mortality . SCD is both an NCD and a recognized as a significant cause of NCD-related morbidity and mortality in persons with (SSA). SCD related NCDs have been observed in the brain, kidneys, heart, and lungs. The overall objective of the work that is proposed in this application is to enhance the SCD associated NCD research capacity in Uganda. This has been informed by the following observations: (a) SCD is very common, affecting over 350,000 people in Uganda, and accounts for 18% of all childhood morbidity . SCD is also associated with reduced life expectancy and poor health related quality of life for survivors. (b) Previous studies on children and adults with SCD in Uganda have highlighted a high prevalence of stroke (6.8%), neurocognitive impairment (21.5%), acute chest syndrome (22.7%), micro-albuminuria, and acute kidney injury. The team will work to achieve the overall objective through the following aims: Aim 1: To train a multi-disciplinary team of research scientists. Aim 2: To increase SCD and associated NCD research capacity across the lifespan. Aim 3: To strengthen local and regional partnerships for advancing SCD and associated NCD research training and advocacy. The activities in this application innovatively exploit the access to large numbers of SCD patients and the multi-disciplinary/inter professional education expertise at Makerere University College of Health Sciences and Busitema University, both in Uganda to increase the local SCD associated NCD research capacity. It is anticipated that by the end of the 5-years support, a critical mass of local research scientists will have been created to support the further growth of a high quality SCD associated NCDs research and clinical care portfolio, focused on low-cost sustainable interventions for SCD affected populations in Uganda and other settings including the USA. 1

项目摘要： 慢性非传染性疾病和疾病（NCD）是全球死亡率的主要原因， 占所有死亡人数的71％。预计到2030年，非洲NCD的死亡将超过 由于传染性，孕产妇，围产期和营养疾病而导致的死亡。 撒哈拉以南非洲 有90％的家 每年出生的30万儿童患有镰状细胞病（SCD）和SCD 在 镰状细胞贫血SSA与16％的儿童死亡率有关 。 SCD既是NCD又是 被认为是（SSA）患者NCD相关发病率和死亡率的重要原因。 scd 已经在大脑，肾脏，心脏和肺中观察到相关的NCD。工作的总体目标 该应用程序中提出的是提高乌干达的SCD相关的NCD研究能力。 以下观察结果已经告知了这一点：（a）SCD非常普遍，影响了350,000多个 乌干达的人，占所有童年发病率的18％ 。 SCD也与减少有关 预期寿命和与健康相关的幸存者的生活质量。 （b）以前关于儿童和 乌干达SCD的成年人突出了中风的高流行（6.8％），神经认知障碍 （21.5％），急性胸部综合征（22.7％），微藻尿症和急性肾脏损伤。团队将努力 通过以下目的实现总体目标：目标1：培训一个多学科团队 研究科学家。目标2：增加整个寿命的SCD和相关的NCD研究能力。 目标3：加强当地和区域伙伴关系，以推进SCD和相关的NCD研究 培训和倡导。本应用程序中的活动创新地利用了对大量的访问 SCD患者和Makerere大学的多学科/专业教育专业知识 卫生科学学院和布斯蒂玛大学，都在乌干达增加当地的SCD相关 NCD研究能力。可以预计，到5年的支持结束，当地的关键质量 将创建研究科学家，以支持高质量SCD相关的进一步增长 NCDS研究和临床护理投资组合，重点介绍SCD受影响的低成本可持续干预措施 乌干达和其他环境在内的人口包括美国。 1