Optimization of a personalized skin cancer risk intervention for at-risk young adults

针对高危年轻人的个性化皮肤癌风险干预措施的优化

基本信息

批准号：
10582944
负责人：
JENNIFER L HAY
金额：
$ 67.2万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10582944
关键词：
Address Affect Appearance Behavior Behavioral Cancer Prevention Intervention Communication Counseling Development Effectiveness of Interventions Elements Enrollment Experimental Designs Feedback Future Genetic Risk Goals Habits Incidence Individual Intervention Intervention Studies Lead Life Malignant Neoplasms Measures Mediating Mediator Metastatic Melanoma Methods Modeling Monitor Outcome Persons Photography Population Prevention Recommendation Research Research Design Risk Risk Behaviors Risk Reduction Seasons Skin Cancer Skin Carcinoma Skin tanning Subgroup Sunburn Test Result Testing Time Treatment Efficacy UV Radiation Exposure Utah Variant Visual Work adaptive intervention aged cancer prevention cancer risk clinically significant college cost demographics design expectation experimental study follow-up genetic testing genetic variant improved improved outcome innovation intervention effect melanoma multidisciplinary multiphase optimization strategy novel novel therapeutics personalized intervention post intervention prevent preventive intervention sex skin cancer prevention skin damage sociodemographics sun protection therapy development ultraviolet university student young adult

Address Affect Appearance Behavior Behavioral Cancer Prevention Intervention Communication Counseling Development Effectiveness of Interventions Elements Enrollment Experimental Designs Feedback Future Genetic Risk Goals Habits Incidence Individual Intervention Intervention Studies Lead Life Malignant Neoplasms Measures Mediating Mediator Metastatic Melanoma Methods Modeling Monitor Outcome Persons Photography Population Prevention Recommendation Research Research Design Risk Risk Behaviors Risk Reduction Seasons Skin Cancer Skin Carcinoma Skin tanning Subgroup Sunburn Test Result Testing Time Treatment Efficacy UV Radiation Exposure Utah Variant Visual Work adaptive intervention aged cancer prevention cancer risk clinically significant college cost demographics design expectation experimental study follow-up genetic testing genetic variant improved improved outcome innovation intervention effect melanoma multidisciplinary multiphase optimization strategy novel novel therapeutics personalized intervention post intervention prevent preventive intervention sex skin cancer prevention skin damage sociodemographics sun protection therapy development ultraviolet university student young adult

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项目摘要

PROJECT SUMMARY Melanoma and non-melanoma skin cancers are common among young adults. Young adults put themselves at increased risk for skin cancers due to their tanning habits and inconsistent use of recommended sun protection methods. Existing interventions for young adults have relied on a one-size-fits-all approach primarily using appearance-focused appeals examining short-term outcomes, and have not examined potential moderators of intervention effects. We designed a skin cancer prevention intervention for college students that incorporates different types of personalized skin cancer risk information (ultraviolet photo showing underlying skin damage, MC1R testing indicating genetic risk for skin cancer, action planning) to increase receptivity to personalized risk information and to facilitate decreased tanning and increased use of sun protection. Our study is guided by the Elaboration Likelihood Model; as such we posit that intervention components will improve outcomes by increasing central processing of highly personally relevant risk and behavioral planning information. In our preliminary studies of these intervention components, we observed decreases in tanning behaviors and increases in sun protection pre- to post-intervention. We propose to apply a Multiphase Optimization Strategy to identify which of the proposed components or their combinations optimally prevent sunburn, and secondarily, which elements discourage tanning and increase use of sun protection in college students over longer term intervals (12+ months). Through a full factorial experiment, we will examine the effects of three personalized risk components: 1) UV photo; 2) MC1R genetic testing results; 3) action planning. We will explore socio-demographic and behavioral moderators of the intervention effects in order to inform the development of future deeply-tailored, optimized adaptive interventions. This project addresses the critical need for efficacious skin cancer preventive interventions for young adults in the college setting. The project will also lead to new scientific understanding of moderators of the intervention effects, which will lead to more deeply tailored interventions that better meet the needs of all young adults.

项目摘要黑色素瘤和非黑色素瘤皮肤癌在年轻人中很常见。年轻人把自己放在由于其晒黑习惯以及不一致的使用建议的防晒，增加了皮肤癌的风险方法。对年轻人的现有干预措施依赖于一种千篇一律的方法 - 主要使用以外观为中心的上诉研究了短期结果，并且没有检查干预效果。我们为大学生设计了一种预防皮肤癌的干预措施不同类型的个性化皮肤癌风险信息（紫外线照片显示潜在的皮肤损害， MC1R测试表明皮肤癌的遗传风险，行动计划）以提高对个性化的接受能力风险信息并促进减少晒黑和增加防晒的使用。我们的研究由详细的可能性模型；因此，我们认为干预组件将通过增加对高度个人相关风险和行为计划信息的中央处理。在我们的对这些干预组件的初步研究，我们观察到晒黑行为和干预前的防晒量增加。我们建议采用多相优化策略确定哪些拟议的组件或它们的组合最佳地防止晒伤，以及其次，哪些元素阻止晒黑并增加大学生的防晒保护长期间隔（12个以上）。通过完整的阶乘实验，我们将研究三个的影响个性化风险组件：1）紫外线照片； 2）MC1R基因检测结果； 3）行动计划。我们将探索干预效果的社会人口统计学和行为主持人，以告知开发未来的深入，优化的自适应干预措施。该项目解决了关键在大学环境中，需要对年轻人进行有效的皮肤癌预防措施。该项目将还会导致对主持人的干预效果的新科学理解，这将导致更多非常量身定制的干预措施，可以更好地满足所有年轻人的需求。