Perception of Gene-Environment Cancer Risks in Melanoma

对黑色素瘤基因环境癌症风险的认识

• 批准号: 7120526
• 负责人: JENNIFER L HAY
• 金额: $ 13.43万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-08 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120526
• 关键词: cancer risk; clinical research; family; gene environment interaction; genetic susceptibility; health behavior; human subject; interview; mass screening; melanoma; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nevus; perception; radiation related neoplasm /cancer; sunburn; sunscreens

DESCRIPTION (provided by applicant): The overall goal of this career development application is to launch an independent research program on perception of gene-environment cancer risks. There is mounting evidence that common genetic polymorphisms can either accentuate or attenuate environmental risks, such as smoking and sun exposure, and that these interactions are a primary etiological pathway to carcinogenesis. In the coming years, it is likely that a growing number of individuals will receive probabilistic information concerning genetic and environmental cancer risk factors. The number of individuals who are affected will exceed those with uncommon, highly penetrant single-gene mutations. Existing research on cancer risk communication targeted to those with single risk factors, such as genetic mutations alone, or lifestyle risk factors alone, do not adequately address the potential challenges and prevention opportunities presented by our increasingly comprehensive understanding of environmental and genetic risk interactions. Gene-environment interactions are implicated in the etiology of a number cancer sites. Melanoma will provide the paradigm for study in this application because of the evidence for gene-environment etiology, rising incidence rates, and promise of behavioral prevention. Given the current absence of identified germ line mutations, studying first-degree relatives of melanoma patients will provide a vehicle in the proposed studies to examine the role of gene-environment risk perceptions and both skin cancer screening and sun protection behavior. Study I is a qualitative interview study of risk perceptions among first-degree relatives of melanoma patients. Study II is a prospective assessment of risk perceptions, skin cancer screening, and sun protection behaviors among first degree-relatives of recently diagnosed melanoma patients. Through intensive interaction with multidisciplinary colleagues, formal epidemiology coursework, teaching, and research, this career development award will establish my multidisciplinary research skills at the interface of genetic epidemiology and behavioral science, and position me to establish novel theory and measurement strategies for the role of risk perceptions of gene-environment interactions, and ultimately to develop communication models of gene-environment cancer risks which will be applicable to other cancer sites.

描述（由申请人提供）：该职业发展应用程序的总体目标是启动有关基因环境癌风险感知的独立研究计划。 有越来越多的证据表明，常见的遗传多态性可以强调或减轻环境风险，例如吸烟和日晒，并且这些相互作用是致癌作用的主要病因途径。 在接下来的几年中，越来越多的人可能会收到有关遗传和环境癌危险因素的概率信息。 受影响的个体的数量将超过那些罕见，高度渗透的单基因突变的人数。 现有的有关具有单一风险因素的癌症风险沟通的研究，例如单独的遗传突变，或仅生活方式风险因素，并不能充分解决我们对环境和遗传风险相互作用日益广泛的了解所带来的潜在挑战和预防机会。 基因环境相互作用与许多癌症部位的病因有关。 黑色素瘤将在此应用中提供研究范式，因为有证据表明基因环境病因，发病率上升和行为预防的承诺。 鉴于目前没有鉴定出的细菌线突变，研究黑色素瘤患者的一级亲戚将在拟议的研究中提供一种载体，以检查基因 - 环境风险感知的作用以及皮肤癌筛查和防晒行为。 研究I是对黑色素瘤患者一级亲属风险感知的定性访谈研究。 研究II是对最近诊断出的黑色素瘤患者一级依赖的风险感知，皮肤癌筛查和防晒行为的前瞻性评估。 Through intensive interaction with multidisciplinary colleagues, formal epidemiology coursework, teaching, and research, this career development award will establish my multidisciplinary research skills at the interface of genetic epidemiology and behavioral science, and position me to establish novel theory and measurement strategies for the role of risk perceptions of gene-environment interactions, and ultimately to develop communication models of gene-environment cancer risks which will be applicable to other癌地点。